Next Generation Sequencing Discoveries of the Nitrate-Responsive Oral Microbiome and Its Effect on Vascular Responses
(2019) In Journal of Clinical Medicine 8(8).- Abstract
Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure-hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate-nitrite-NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral... (More)
Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure-hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate-nitrite-NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.
(Less)
- author
- Grant, Melissa M and Jönsson, Daniel LU
- publishing date
- 2019-07-26
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- oral microbiome, saliva, nitric oxide, nitrate, nitrite
- in
- Journal of Clinical Medicine
- volume
- 8
- issue
- 8
- article number
- 1110
- pages
- 9 pages
- publisher
- MDPI AG
- external identifiers
-
- pmid:31357429
- scopus:85084002703
- ISSN
- 2077-0383
- DOI
- 10.3390/jcm8081110
- language
- English
- LU publication?
- no
- id
- 5b6d8f49-d9b1-400b-877c-94a648508f1c
- date added to LUP
- 2024-07-05 12:13:46
- date last changed
- 2024-07-06 04:06:46
@article{5b6d8f49-d9b1-400b-877c-94a648508f1c,
abstract = {{<p>Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure-hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate-nitrite-NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.</p>}},
author = {{Grant, Melissa M and Jönsson, Daniel}},
issn = {{2077-0383}},
keywords = {{oral microbiome; saliva; nitric oxide; nitrate; nitrite}},
language = {{eng}},
month = {{07}},
number = {{8}},
publisher = {{MDPI AG}},
series = {{Journal of Clinical Medicine}},
title = {{Next Generation Sequencing Discoveries of the Nitrate-Responsive Oral Microbiome and Its Effect on Vascular Responses}},
url = {{http://dx.doi.org/10.3390/jcm8081110}},
doi = {{10.3390/jcm8081110}},
volume = {{8}},
year = {{2019}},
}