Neocortical interpretation of haptic and visual events across brain states: Electrophysiological investigations in sensory information processing
(2024) In Lund University, Faculty of Medicine Doctoral Dissertation Series- Abstract
- This thesis delves into the complex architecture of dynamic sensory information processing in the neocortex. Specifically, it asks how primary sensory cortical regions are influenced by local and widespread cortical state changes. Central to this question is the exploration of two historically opposing information processing frameworks emphasizing a local and global information processing principle respectively, i.e. the principle that certain areas of the brain are dedicated to specific functions and the principle that individual functions are distributed over a large network.
Results were obtained through in vivo extracellular recordings in anesthetized rats while high-resolution spatiotemporal visual, tactile, and visuo-tactile... (More) - This thesis delves into the complex architecture of dynamic sensory information processing in the neocortex. Specifically, it asks how primary sensory cortical regions are influenced by local and widespread cortical state changes. Central to this question is the exploration of two historically opposing information processing frameworks emphasizing a local and global information processing principle respectively, i.e. the principle that certain areas of the brain are dedicated to specific functions and the principle that individual functions are distributed over a large network.
Results were obtained through in vivo extracellular recordings in anesthetized rats while high-resolution spatiotemporal visual, tactile, and visuo-tactile input patterns were provided. Paper I showed that color input evokes rapid local state changes in primary visual cortex (V1) which result in unique temporal response patterns among neurons recorded within the same vertical axis, thereby challenging the historically popular idea of columnar organization. Paper II used field potential recordings as estimates of changes in the widespread and local cortical state and showed a significant differential effect on individual neuronal responses to haptic input in the primary somatosensory cortex (S1). In paper III, spontaneous activity among S1 neuron populations was defined as a high-dimensional state space that was found to shift in different ways when providing tactile, visual, and visuo-tactile input, questioning the idea of unimodal cortical regions.
Together, the results suggest that both local and widespread internal brain states can impact processing of sensory information in primary sensory regions. It is concluded that the functional localization model cannot fully explain what we and other researchers have observed about cortical sensory information processing and that brain state dependence on the neuronal representation of sensory input is more likely a result of coordinated activity across multiple, interconnected brain regions.
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Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5b908f8b-d0f3-4c85-bbaa-cebd8bdae999
- author
- Skårup Kristensen, Sofie LU
- supervisor
- opponent
-
- Professor Oalusson, Håkan, Linköping University, Sweden
- organization
- publishing date
- 2024
- type
- Thesis
- publication status
- published
- subject
- keywords
- Haptics, Visual, Multisensory, Cortical, Rodent, Neurophysiology, Tactile, Electrophysiology
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2024:64
- pages
- 72 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Segerfalksalen, BMC A10, Sölvegatan 17 i Lund. Join by Zoom: https://lu-se.zoom.us/j/62438522869
- defense date
- 2024-05-10 13:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-557-2
- language
- English
- LU publication?
- yes
- id
- 5b908f8b-d0f3-4c85-bbaa-cebd8bdae999
- date added to LUP
- 2024-04-10 09:47:17
- date last changed
- 2024-04-29 12:49:43
@phdthesis{5b908f8b-d0f3-4c85-bbaa-cebd8bdae999,
abstract = {{This thesis delves into the complex architecture of dynamic sensory information processing in the neocortex. Specifically, it asks how primary sensory cortical regions are influenced by local and widespread cortical state changes. Central to this question is the exploration of two historically opposing information processing frameworks emphasizing a local and global information processing principle respectively, i.e. the principle that certain areas of the brain are dedicated to specific functions and the principle that individual functions are distributed over a large network.<br/><br/>Results were obtained through in vivo extracellular recordings in anesthetized rats while high-resolution spatiotemporal visual, tactile, and visuo-tactile input patterns were provided. Paper I showed that color input evokes rapid local state changes in primary visual cortex (V1) which result in unique temporal response patterns among neurons recorded within the same vertical axis, thereby challenging the historically popular idea of columnar organization. Paper II used field potential recordings as estimates of changes in the widespread and local cortical state and showed a significant differential effect on individual neuronal responses to haptic input in the primary somatosensory cortex (S1). In paper III, spontaneous activity among S1 neuron populations was defined as a high-dimensional state space that was found to shift in different ways when providing tactile, visual, and visuo-tactile input, questioning the idea of unimodal cortical regions. <br/><br/>Together, the results suggest that both local and widespread internal brain states can impact processing of sensory information in primary sensory regions. It is concluded that the functional localization model cannot fully explain what we and other researchers have observed about cortical sensory information processing and that brain state dependence on the neuronal representation of sensory input is more likely a result of coordinated activity across multiple, interconnected brain regions.<br/>}},
author = {{Skårup Kristensen, Sofie}},
isbn = {{978-91-8021-557-2}},
issn = {{1652-8220}},
keywords = {{Haptics; Visual; Multisensory; Cortical; Rodent; Neurophysiology; Tactile; Electrophysiology}},
language = {{eng}},
number = {{2024:64}},
publisher = {{Lund University, Faculty of Medicine}},
school = {{Lund University}},
series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}},
title = {{Neocortical interpretation of haptic and visual events across brain states: Electrophysiological investigations in sensory information processing}},
url = {{https://lup.lub.lu.se/search/files/179785512/e-spik_ex_sofie.pdf}},
year = {{2024}},
}