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Effects of plasmapheresis on the plasma concentration of proteins used to monitor the disease process in multiple myeloma

Wahlin, Anders ; Grubb, Anders LU orcid ; Holm, Jan LU and Marklund, Stefan L (1988) In Acta Medica Scandinavica 223(3). p.263-267
Abstract

We studied the influence of plasmapheresis on the plasma concentrations of proteins (IgG, IgA, beta 2-microglobulin) used for estimation of tumour cell mass in patients with multiple myeloma. Simultaneously, the effects of plasmapheresis on plasma concentrations of proteins (CRP, alpha 1-antitrypsin, haptoglobin) used for the assessment of inflammatory processes were studied. Also, changes in the plasma concentration of protein HC, a recently described protein occurring both as a free protein and as an IgA complex, were studied. The influence of plasmapheresis varied for the different proteins. The plasma levels of IgG, IgA, CRP, alpha 1-antitrypsin, and haptoglobin decreased during plasmapheresis. The simultaneous reduction of the... (More)

We studied the influence of plasmapheresis on the plasma concentrations of proteins (IgG, IgA, beta 2-microglobulin) used for estimation of tumour cell mass in patients with multiple myeloma. Simultaneously, the effects of plasmapheresis on plasma concentrations of proteins (CRP, alpha 1-antitrypsin, haptoglobin) used for the assessment of inflammatory processes were studied. Also, changes in the plasma concentration of protein HC, a recently described protein occurring both as a free protein and as an IgA complex, were studied. The influence of plasmapheresis varied for the different proteins. The plasma levels of IgG, IgA, CRP, alpha 1-antitrypsin, and haptoglobin decreased during plasmapheresis. The simultaneous reduction of the level of protein HC was smaller than that of IgG, IgA and haptoglobin. The plasma concentration of beta 2-microglobulin did not decrease during plasmapheresis. The recovery rates of the proteins were found to be approximately inversely related to their molecular weights.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha-Globulins/analysis, Blood Proteins/analysis, Humans, Multiple Myeloma/blood, Plasmapheresis
in
Acta Medica Scandinavica
volume
223
issue
3
pages
263 - 267
publisher
Wiley-Blackwell
external identifiers
  • pmid:2451397
  • scopus:0023909537
ISSN
0001-6101
DOI
10.1111/j.0954-6820.1988.tb15796.x
language
English
LU publication?
yes
id
5bfcdda0-48d4-4eb8-bc32-d147f137851c
date added to LUP
2021-10-27 09:06:47
date last changed
2025-10-14 09:04:12
@article{5bfcdda0-48d4-4eb8-bc32-d147f137851c,
  abstract     = {{<p>We studied the influence of plasmapheresis on the plasma concentrations of proteins (IgG, IgA, beta 2-microglobulin) used for estimation of tumour cell mass in patients with multiple myeloma. Simultaneously, the effects of plasmapheresis on plasma concentrations of proteins (CRP, alpha 1-antitrypsin, haptoglobin) used for the assessment of inflammatory processes were studied. Also, changes in the plasma concentration of protein HC, a recently described protein occurring both as a free protein and as an IgA complex, were studied. The influence of plasmapheresis varied for the different proteins. The plasma levels of IgG, IgA, CRP, alpha 1-antitrypsin, and haptoglobin decreased during plasmapheresis. The simultaneous reduction of the level of protein HC was smaller than that of IgG, IgA and haptoglobin. The plasma concentration of beta 2-microglobulin did not decrease during plasmapheresis. The recovery rates of the proteins were found to be approximately inversely related to their molecular weights.</p>}},
  author       = {{Wahlin, Anders and Grubb, Anders and Holm, Jan and Marklund, Stefan L}},
  issn         = {{0001-6101}},
  keywords     = {{Alpha-Globulins/analysis; Blood Proteins/analysis; Humans; Multiple Myeloma/blood; Plasmapheresis}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{263--267}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Medica Scandinavica}},
  title        = {{Effects of plasmapheresis on the plasma concentration of proteins used to monitor the disease process in multiple myeloma}},
  url          = {{http://dx.doi.org/10.1111/j.0954-6820.1988.tb15796.x}},
  doi          = {{10.1111/j.0954-6820.1988.tb15796.x}},
  volume       = {{223}},
  year         = {{1988}},
}