Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Gas monitoring in human frontal sinuses-stability considerations and gas exchange studies

Zhang, Han ; Han, Ning ; Lin, Yueyu ; Huang, Jiawen ; Svanberg, Sune LU and Svanberg, Katarina LU (2021) In Sensors 21(13).
Abstract

Acute rhinosinusitis is a common infectious disease, which, in more than 90% of cases, is caused by viruses rather than by bacteria. Even so, antibiotics are often unnecessarily prescribed, and in the long run this contributes to the alarming level of antibiotics resistance. The reason is that there are no good guiding tools for defining the background reason of the infection. One main factor for the clearance of the infection is if there is non-obstructed ventilation from the sinus to the nasal cavity. Gas in Scattering Media Absorption Spectroscopy (GASMAS) has potential for diagnosing this. We have performed a study of frontal sinuses of volunteers with a focus on signal stability and reproducibility over time, accurate oxygen... (More)

Acute rhinosinusitis is a common infectious disease, which, in more than 90% of cases, is caused by viruses rather than by bacteria. Even so, antibiotics are often unnecessarily prescribed, and in the long run this contributes to the alarming level of antibiotics resistance. The reason is that there are no good guiding tools for defining the background reason of the infection. One main factor for the clearance of the infection is if there is non-obstructed ventilation from the sinus to the nasal cavity. Gas in Scattering Media Absorption Spectroscopy (GASMAS) has potential for diagnosing this. We have performed a study of frontal sinuses of volunteers with a focus on signal stability and reproducibility over time, accurate oxygen concentration determination, and assessment of gas transport through passages, naturally and after decongestant spray administration. Different from earlier studies on frontal sinuses, water vapor, serving the purpose of oxygen signal normalization, was measured at 818 nm rather than earlier at 937 nm, now closer to the 760 nm oxygen absorption band and thus resulting in more reliable results. In addition, the action of decongestants was objectively demonstrated for the first time. Evaluated oxygen concentration values for left-and right-hand side sinus cavities were found to agree within 0.3%, and a left-right geometrical asymmetry parameter related to anatomical differences was stable within 10%.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Frontal sinuses, GASMAS, Laser spectroscopy, Optical diagnostics, Rhinosinusitis
in
Sensors
volume
21
issue
13
article number
4413
publisher
MDPI AG
external identifiers
  • scopus:85108704884
  • pmid:34203142
ISSN
1424-8220
DOI
10.3390/s21134413
language
English
LU publication?
yes
id
5c02471c-ddf1-4493-ab2d-7a21dd4252bd
date added to LUP
2021-08-17 16:29:30
date last changed
2024-03-23 08:01:56
@article{5c02471c-ddf1-4493-ab2d-7a21dd4252bd,
  abstract     = {{<p>Acute rhinosinusitis is a common infectious disease, which, in more than 90% of cases, is caused by viruses rather than by bacteria. Even so, antibiotics are often unnecessarily prescribed, and in the long run this contributes to the alarming level of antibiotics resistance. The reason is that there are no good guiding tools for defining the background reason of the infection. One main factor for the clearance of the infection is if there is non-obstructed ventilation from the sinus to the nasal cavity. Gas in Scattering Media Absorption Spectroscopy (GASMAS) has potential for diagnosing this. We have performed a study of frontal sinuses of volunteers with a focus on signal stability and reproducibility over time, accurate oxygen concentration determination, and assessment of gas transport through passages, naturally and after decongestant spray administration. Different from earlier studies on frontal sinuses, water vapor, serving the purpose of oxygen signal normalization, was measured at 818 nm rather than earlier at 937 nm, now closer to the 760 nm oxygen absorption band and thus resulting in more reliable results. In addition, the action of decongestants was objectively demonstrated for the first time. Evaluated oxygen concentration values for left-and right-hand side sinus cavities were found to agree within 0.3%, and a left-right geometrical asymmetry parameter related to anatomical differences was stable within 10%.</p>}},
  author       = {{Zhang, Han and Han, Ning and Lin, Yueyu and Huang, Jiawen and Svanberg, Sune and Svanberg, Katarina}},
  issn         = {{1424-8220}},
  keywords     = {{Frontal sinuses; GASMAS; Laser spectroscopy; Optical diagnostics; Rhinosinusitis}},
  language     = {{eng}},
  number       = {{13}},
  publisher    = {{MDPI AG}},
  series       = {{Sensors}},
  title        = {{Gas monitoring in human frontal sinuses-stability considerations and gas exchange studies}},
  url          = {{http://dx.doi.org/10.3390/s21134413}},
  doi          = {{10.3390/s21134413}},
  volume       = {{21}},
  year         = {{2021}},
}