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Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes

Chorell, Elin; Hall, Ulrika Andersson; Gustavsson, Carolina; Berntorp, Kerstin LU ; Puhkala, Jatta; Luoto, Riitta; Olsson, Tommy and Holmäng, Agneta (2017) In Metabolism: Clinical and Experimental 72. p.27-36
Abstract

Context Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Design The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum... (More)

Context Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Design The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32 ± 0.6) and postpartum (10.5 ± 0.4 months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. Results Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. Conclusions Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Branched-chain amino acids, Gestational diabetes mellitus, Metabolomics, Multivariate statistics, Type 2 diabetes mellitus
in
Metabolism: Clinical and Experimental
volume
72
pages
27 - 36
publisher
Elsevier
external identifiers
  • scopus:85018508583
  • wos:000404316600004
ISSN
0026-0495
DOI
10.1016/j.metabol.2016.12.018
language
English
LU publication?
yes
id
5c0a51a1-8164-4d51-9871-559f2a81b7ea
date added to LUP
2017-05-24 12:23:57
date last changed
2017-09-20 09:22:20
@article{5c0a51a1-8164-4d51-9871-559f2a81b7ea,
  abstract     = {<p>Context Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Design The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32 ± 0.6) and postpartum (10.5 ± 0.4 months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. Results Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. Conclusions Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy.</p>},
  author       = {Chorell, Elin and Hall, Ulrika Andersson and Gustavsson, Carolina and Berntorp, Kerstin and Puhkala, Jatta and Luoto, Riitta and Olsson, Tommy and Holmäng, Agneta},
  issn         = {0026-0495},
  keyword      = {Branched-chain amino acids,Gestational diabetes mellitus,Metabolomics,Multivariate statistics,Type 2 diabetes mellitus},
  language     = {eng},
  month        = {07},
  pages        = {27--36},
  publisher    = {Elsevier},
  series       = {Metabolism: Clinical and Experimental},
  title        = {Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes},
  url          = {http://dx.doi.org/10.1016/j.metabol.2016.12.018},
  volume       = {72},
  year         = {2017},
}