Synthesis of α-trinositol related analogues. Structure-activity (analgesic and anti-inflammatory) relationships
Ballereau, S ; Rehnberg, N LU
; Spiess, B
; Gigg, J
; Gigg, R
and Schlewer, G
(1997)
In European Journal of Medicinal Chemistry
32(6).
p.535-540
- Abstract
α-Trinositol analogues, including methyl ethers, deoxy, oxa and aza derivatives were prepared. The parent compound possesses weak analgesic and anti-inflammatory properties. Removal of the non-phosphorylated hydroxyls generates a compound devoid of analgesic activity but which retains the anti-inflammatory property of the parent compound. The protection of these hydroxyls as methyl ethers lends to compounds which keep their anti-inflammatory activity, whereas the replacement of the cyclohexane carbone backbone by a tetrahydropyrane or a piperidine ring leads to compounds which increase the pain.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5c103776-ae11-40d2-93ad-eac7fe63597f
- author
- Ballereau, S
; Rehnberg, N
LU
; Spiess, B
; Gigg, J
; Gigg, R
and Schlewer, G
- publishing date
- 1997-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Analgesic activity, Anti-inflammatory activity, Aza-inositol, Inositol phosphate, Oxa-inositol, α-Trinositol
- in
- European Journal of Medicinal Chemistry
- volume
- 32
- issue
- 6
- pages
- 6 pages
- publisher
- Elsevier Masson SAS
- external identifiers
-
- scopus:0031001478
- ISSN
- 0223-5234
- DOI
- 10.1016/S0223-5234(97)84017-2
- language
- English
- LU publication?
- no
- id
- 5c103776-ae11-40d2-93ad-eac7fe63597f
- date added to LUP
- 2021-11-11 13:00:38
- date last changed
- 2022-02-02 01:16:14
@article{5c103776-ae11-40d2-93ad-eac7fe63597f,
abstract = {{<p>α-Trinositol analogues, including methyl ethers, deoxy, oxa and aza derivatives were prepared. The parent compound possesses weak analgesic and anti-inflammatory properties. Removal of the non-phosphorylated hydroxyls generates a compound devoid of analgesic activity but which retains the anti-inflammatory property of the parent compound. The protection of these hydroxyls as methyl ethers lends to compounds which keep their anti-inflammatory activity, whereas the replacement of the cyclohexane carbone backbone by a tetrahydropyrane or a piperidine ring leads to compounds which increase the pain.</p>}},
author = {{Ballereau, S and Rehnberg, N and Spiess, B and Gigg, J and Gigg, R and Schlewer, G}},
issn = {{0223-5234}},
keywords = {{Analgesic activity; Anti-inflammatory activity; Aza-inositol; Inositol phosphate; Oxa-inositol; α-Trinositol}},
language = {{eng}},
number = {{6}},
pages = {{535--540}},
publisher = {{Elsevier Masson SAS}},
series = {{European Journal of Medicinal Chemistry}},
title = {{Synthesis of α-trinositol related analogues. Structure-activity (analgesic and anti-inflammatory) relationships}},
url = {{http://dx.doi.org/10.1016/S0223-5234(97)84017-2}},
doi = {{10.1016/S0223-5234(97)84017-2}},
volume = {{32}},
year = {{1997}},
}