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Recommendations for Core Outcome Domain Set for Whiplash Associated Disorders (CATWAD)

Chen, Kenneth; Andersen, Tonny; Carroll, Linda; Connelly, Luke; Côté, Pierre; Curatolo, Michele; Elliott, James; Grant, Genevieve; Jull, Gwendolen and Kasch, Helge, et al. (2019) In Clinical Journal of Pain
Abstract

Objective: Inconsistent reporting of outcomes in clinical trials of treatments for Whiplash Associated Disorders (WAD) hinders effective data pooling and conclusions that can be drawn about the effectiveness of tested treatments. The aim of this study was to provide recommendations for core outcome domains that should be included in clinical trials of WAD. Methods: A three-step process was used. 1) A list of potential core outcome domains were identified from the published literature; 2) Researchers, health care providers, patients and insurance personnel participated and rated the importance of each domain via a three round Delphi survey. A priori criteria for consensus were established; 3) Experts comprising researchers, health care... (More)

Objective: Inconsistent reporting of outcomes in clinical trials of treatments for Whiplash Associated Disorders (WAD) hinders effective data pooling and conclusions that can be drawn about the effectiveness of tested treatments. The aim of this study was to provide recommendations for core outcome domains that should be included in clinical trials of WAD. Methods: A three-step process was used. 1) A list of potential core outcome domains were identified from the published literature; 2) Researchers, health care providers, patients and insurance personnel participated and rated the importance of each domain via a three round Delphi survey. A priori criteria for consensus were established; 3) Experts comprising researchers, health care providers and a consumer representative participated in a multidisciplinary consensus meeting that made final decisions on the recommended core outcome domains. Results: The literature search identified 63 potential core domains. 223 participants were invited to partake in the Delphi surveys with 41.7% completing Round 1, 45.3% Round 2 and 51.4% Round 3. Eleven core domains met the criteria for inclusion across the entire sample. After the expert consensus meeting, six core domains were recommended: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life and Pain. Discussion: A 3-step process was used to recommend core outcome domains for clinical trials in WAD. Six core domains were recommended: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life and Pain. The next step is to determine the outcome measurement instruments for each of these domains.

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@article{5c12f960-4de4-4a7d-93ca-81369b05644c,
  abstract     = {<p>Objective: Inconsistent reporting of outcomes in clinical trials of treatments for Whiplash Associated Disorders (WAD) hinders effective data pooling and conclusions that can be drawn about the effectiveness of tested treatments. The aim of this study was to provide recommendations for core outcome domains that should be included in clinical trials of WAD. Methods: A three-step process was used. 1) A list of potential core outcome domains were identified from the published literature; 2) Researchers, health care providers, patients and insurance personnel participated and rated the importance of each domain via a three round Delphi survey. A priori criteria for consensus were established; 3) Experts comprising researchers, health care providers and a consumer representative participated in a multidisciplinary consensus meeting that made final decisions on the recommended core outcome domains. Results: The literature search identified 63 potential core domains. 223 participants were invited to partake in the Delphi surveys with 41.7% completing Round 1, 45.3% Round 2 and 51.4% Round 3. Eleven core domains met the criteria for inclusion across the entire sample. After the expert consensus meeting, six core domains were recommended: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life and Pain. Discussion: A 3-step process was used to recommend core outcome domains for clinical trials in WAD. Six core domains were recommended: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life and Pain. The next step is to determine the outcome measurement instruments for each of these domains.</p>},
  author       = {Chen, Kenneth and Andersen, Tonny and Carroll, Linda and Connelly, Luke and Côté, Pierre and Curatolo, Michele and Elliott, James and Grant, Genevieve and Jull, Gwendolen and Kasch, Helge and MacDermid, Joy and Malmström, Eva Maj and Maujean, Annick and McLean, Samuel A. and Nielsen, Mandy and Rebbeck, Trudy and Söderlund, Anne and Sterling, Joanna and Treleaven, Julia and Walton, David M. and Westergren, Hans and Sterling, Michele},
  issn         = {0749-8047},
  keyword      = {domains,neck,outcome,pain,whiplash},
  language     = {eng},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Clinical Journal of Pain},
  title        = {Recommendations for Core Outcome Domain Set for Whiplash Associated Disorders (CATWAD)},
  url          = {http://dx.doi.org/10.1097/AJP.0000000000000735},
  year         = {2019},
}