Motor properties from persistence: a linear molecular walker lacking spatial and temporal asymmetry
Zuckermann, Martin J. ; Angstmann, Christopher N. ; Schmitt, Regina LU ; Blab, Gerhard A. ; Bromley, Elizabeth H. C. ; Forde, Nancy R. ; Linke, Heiner LU
and Curmi, Paul M. G.
(2015)
In New Journal of Physics
17.
- Abstract
- The stepping direction of linear molecular motors is usually defined by a spatial asymmetry of the motor, its track, or both. Here we present a model for a molecular walker that undergoes biased directional motion along a symmetric track in the presence of a temporally symmetric chemical cycle. Instead of using asymmetry, directionality is achieved by persistence. At small load force the walker can take on average thousands of steps in a given direction until it stochastically reverses direction. We discuss a specific experimental implementation of a synthetic motor based on this design and find, using Langevin and Monte Carlo simulations, that a realistic walker can work against load forces on the order of picoNewtons with an efficiency... (More)
- The stepping direction of linear molecular motors is usually defined by a spatial asymmetry of the motor, its track, or both. Here we present a model for a molecular walker that undergoes biased directional motion along a symmetric track in the presence of a temporally symmetric chemical cycle. Instead of using asymmetry, directionality is achieved by persistence. At small load force the walker can take on average thousands of steps in a given direction until it stochastically reverses direction. We discuss a specific experimental implementation of a synthetic motor based on this design and find, using Langevin and Monte Carlo simulations, that a realistic walker can work against load forces on the order of picoNewtons with an efficiency of similar to 18%, comparable to that of kinesin. In principle, the walker can be turned into a permanent motor by externally monitoring the walker's momentary direction of motion, and using feedback to adjust the direction of a load force. We calculate the thermodynamic cost of using feedback to enhance motor performance in terms of the Shannon entropy, and find that it reduces the efficiency of a realistic motor only marginally. We discuss the implications for natural protein motor performance in the context of the strong performance of this design based only on a thermal ratchet. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7410694
- author
- Zuckermann, Martin J.
; Angstmann, Christopher N.
; Schmitt, Regina
LU
; Blab, Gerhard A.
; Bromley, Elizabeth H. C.
; Forde, Nancy R.
; Linke, Heiner
LU
and Curmi, Paul M. G.
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- feedback control, artificial protein motor, Langevin dynamics, kinesin, Brownian ratchet, molecular motor
- in
- New Journal of Physics
- volume
- 17
- article number
- 055017
- publisher
- IOP Publishing
- external identifiers
-
- wos:000355280000001
- scopus:84930010334
- ISSN
- 1367-2630
- DOI
- 10.1088/1367-2630/17/5/055017
- language
- English
- LU publication?
- yes
- id
- 5c19eec4-19fa-46f3-96b4-fe4a9ed68ede (old id 7410694)
- date added to LUP
- 2016-04-01 13:48:54
- date last changed
- 2023-10-29 14:41:15
@article{5c19eec4-19fa-46f3-96b4-fe4a9ed68ede,
abstract = {{The stepping direction of linear molecular motors is usually defined by a spatial asymmetry of the motor, its track, or both. Here we present a model for a molecular walker that undergoes biased directional motion along a symmetric track in the presence of a temporally symmetric chemical cycle. Instead of using asymmetry, directionality is achieved by persistence. At small load force the walker can take on average thousands of steps in a given direction until it stochastically reverses direction. We discuss a specific experimental implementation of a synthetic motor based on this design and find, using Langevin and Monte Carlo simulations, that a realistic walker can work against load forces on the order of picoNewtons with an efficiency of similar to 18%, comparable to that of kinesin. In principle, the walker can be turned into a permanent motor by externally monitoring the walker's momentary direction of motion, and using feedback to adjust the direction of a load force. We calculate the thermodynamic cost of using feedback to enhance motor performance in terms of the Shannon entropy, and find that it reduces the efficiency of a realistic motor only marginally. We discuss the implications for natural protein motor performance in the context of the strong performance of this design based only on a thermal ratchet.}},
author = {{Zuckermann, Martin J. and Angstmann, Christopher N. and Schmitt, Regina and Blab, Gerhard A. and Bromley, Elizabeth H. C. and Forde, Nancy R. and Linke, Heiner and Curmi, Paul M. G.}},
issn = {{1367-2630}},
keywords = {{feedback control; artificial protein motor; Langevin dynamics; kinesin; Brownian ratchet; molecular motor}},
language = {{eng}},
publisher = {{IOP Publishing}},
series = {{New Journal of Physics}},
title = {{Motor properties from persistence: a linear molecular walker lacking spatial and temporal asymmetry}},
url = {{http://dx.doi.org/10.1088/1367-2630/17/5/055017}},
doi = {{10.1088/1367-2630/17/5/055017}},
volume = {{17}},
year = {{2015}},
}