Type 1 diabetes in Swedish bank voles (Clethrionomys glareolus): signs of disease in both colonized and wild cyclic populations at peak density.
Niklasson, Bo ; Hörnfeldt, Birger ; Nyholm, Erik ; Niedrig, Matthias ; Donoso-Mantke, Oliver ; Gelderblom, Hans R and Lernmark, Åke LU
(2003)
In Annals of the New York Academy of Sciences
1005(1).
p.170-175
- Abstract
- Colonized bank voles (Clethrionomys glareolus) originating from Sweden developed type 1 diabetes. Animals became polydipsic, glucosuric, and hyperglycemic and gradually developed a lethal ketoacidosis. Pancreas in animals with end-stage disease showed total destruction of islet cells. Interestingly, also a high proportion of wild bank voles in cyclic populations that were trapped at (or close to) the cyclic population density peak frequently showed high blood glucose levels and pathological glucose tolerance test. Extensive islet destruction was not seen in wild bank voles at the time of capture, but did develop in some of the animals over a time period of two months. Diabetes in both colonized and wild bank voles was associated with... (More)
- Colonized bank voles (Clethrionomys glareolus) originating from Sweden developed type 1 diabetes. Animals became polydipsic, glucosuric, and hyperglycemic and gradually developed a lethal ketoacidosis. Pancreas in animals with end-stage disease showed total destruction of islet cells. Interestingly, also a high proportion of wild bank voles in cyclic populations that were trapped at (or close to) the cyclic population density peak frequently showed high blood glucose levels and pathological glucose tolerance test. Extensive islet destruction was not seen in wild bank voles at the time of capture, but did develop in some of the animals over a time period of two months. Diabetes in both colonized and wild bank voles was associated with Ljungan virus (LV). LV could be isolated from the pancreas of diabetic bank voles and antigen detected at the site of tissue damage by immunohistochemistry. In addition, picornavirus-like particles were visualized in the islets of diabetic voles using thin (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1127387
- author
- Niklasson, Bo
; Hörnfeldt, Birger
; Nyholm, Erik
; Niedrig, Matthias
; Donoso-Mantke, Oliver
; Gelderblom, Hans R
and Lernmark, Åke
LU
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of the New York Academy of Sciences
- volume
- 1005
- issue
- 1
- pages
- 170 - 175
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:11144357023
- ISSN
- 0077-8923
- DOI
- 10.1196/annals.1288.020
- language
- English
- LU publication?
- no
- id
- 5c3bad1d-4330-4196-b783-fb70b2c9d2ef (old id 1127387)
- date added to LUP
- 2016-04-01 16:39:55
- date last changed
- 2022-01-28 21:17:40
@article{5c3bad1d-4330-4196-b783-fb70b2c9d2ef,
abstract = {{Colonized bank voles (Clethrionomys glareolus) originating from Sweden developed type 1 diabetes. Animals became polydipsic, glucosuric, and hyperglycemic and gradually developed a lethal ketoacidosis. Pancreas in animals with end-stage disease showed total destruction of islet cells. Interestingly, also a high proportion of wild bank voles in cyclic populations that were trapped at (or close to) the cyclic population density peak frequently showed high blood glucose levels and pathological glucose tolerance test. Extensive islet destruction was not seen in wild bank voles at the time of capture, but did develop in some of the animals over a time period of two months. Diabetes in both colonized and wild bank voles was associated with Ljungan virus (LV). LV could be isolated from the pancreas of diabetic bank voles and antigen detected at the site of tissue damage by immunohistochemistry. In addition, picornavirus-like particles were visualized in the islets of diabetic voles using thin}},
author = {{Niklasson, Bo and Hörnfeldt, Birger and Nyholm, Erik and Niedrig, Matthias and Donoso-Mantke, Oliver and Gelderblom, Hans R and Lernmark, Åke}},
issn = {{0077-8923}},
language = {{eng}},
number = {{1}},
pages = {{170--175}},
publisher = {{Wiley-Blackwell}},
series = {{Annals of the New York Academy of Sciences}},
title = {{Type 1 diabetes in Swedish bank voles (Clethrionomys glareolus): signs of disease in both colonized and wild cyclic populations at peak density.}},
url = {{http://dx.doi.org/10.1196/annals.1288.020}},
doi = {{10.1196/annals.1288.020}},
volume = {{1005}},
year = {{2003}},
}