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Standard mortality rates and years of life lost for serologically defined adult-onset type 1 and type 2 diabetes – A fifteen year follow-up

Thunander, Maria LU ; Lindgren, Anna LU ; Petersson, Christer ; Landin-Olsson, Mona LU and Holmberg, Sara LU (2020) In Diabetes Research and Clinical Practice 160.
Abstract

Aims: The Diabetes Incidence in Kronoberg (DIK) study of adult-onset diabetes used serological classification. Standard Mortality Rates (SMR) and Years of Life Lost (YLL) 15 years after adult-onset (18–100 years) of diabetes were compared to the population of Kronoberg. Methods: Of 1609/1660 (97%) patients, 112 (7%) had type 1 (T1D) (GADA+ and/or ICA+, and/or C-peptide < 0.25 nmol/l), and 1497 (93%) had type 2 diabetes (T2D) (antibody- and C-peptide ≥ 0.25 nmol/l). The National Swedish Mortality Register provided time of death. Results: For T1D SMR did not differ from the Kronoberg population in any age group. In T2D SMR was 1.20 (1.12–1.29). After 15 years 26% (29/112) T1D and 52% (785/1497) T2D... (More)

Aims: The Diabetes Incidence in Kronoberg (DIK) study of adult-onset diabetes used serological classification. Standard Mortality Rates (SMR) and Years of Life Lost (YLL) 15 years after adult-onset (18–100 years) of diabetes were compared to the population of Kronoberg. Methods: Of 1609/1660 (97%) patients, 112 (7%) had type 1 (T1D) (GADA+ and/or ICA+, and/or C-peptide < 0.25 nmol/l), and 1497 (93%) had type 2 diabetes (T2D) (antibody- and C-peptide ≥ 0.25 nmol/l). The National Swedish Mortality Register provided time of death. Results: For T1D SMR did not differ from the Kronoberg population in any age group. In T2D SMR was 1.20 (1.12–1.29). After 15 years 26% (29/112) T1D and 52% (785/1497) T2D patients had died, p < 0.0001. In T2D SMR was 5.6 (30–39 years), 2 (40–59 years), 1.4 (60–69 years), and thereafter no difference. There were no significant sex differences in mortality, and no YLL to adult-onset T1D, but five YLL to T2D for onset at ages 20–60 years. Conclusions: For adult-onset T1D SMR did not differ from the general population, in contrast to previous findings in childhood-onset (< 30 years of age) T1D. The difference in mortality between persons with diabetes and the general population was due to higher mortality in T2D.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-peptide, Classification, Islet antibodies, Mortality, SMR, Years of life lost
in
Diabetes Research and Clinical Practice
volume
160
article number
107943
publisher
Elsevier
external identifiers
  • pmid:31765685
  • scopus:85078045466
ISSN
0168-8227
DOI
10.1016/j.diabres.2019.107943
language
English
LU publication?
yes
id
5c434ab5-0a35-4365-9f72-49cfc81773b1
date added to LUP
2021-01-13 00:09:10
date last changed
2024-05-30 04:13:00
@article{5c434ab5-0a35-4365-9f72-49cfc81773b1,
  abstract     = {{<p>Aims: The Diabetes Incidence in Kronoberg (DIK) study of adult-onset diabetes used serological classification. Standard Mortality Rates (SMR) and Years of Life Lost (YLL) 15 years after adult-onset (18–100 years) of diabetes were compared to the population of Kronoberg. Methods: Of 1609/1660 (97%) patients, 112 (7%) had type 1 (T1D) (GADA<sup>+</sup> and/or ICA<sup>+</sup>, and/or C-peptide &lt; 0.25 nmol/l), and 1497 (93%) had type 2 diabetes (T2D) (antibody<sup>-</sup> and C-peptide ≥ 0.25 nmol/l). The National Swedish Mortality Register provided time of death. Results: For T1D SMR did not differ from the Kronoberg population in any age group. In T2D SMR was 1.20 (1.12–1.29). After 15 years 26% (29/112) T1D and 52% (785/1497) T2D patients had died, p &lt; 0.0001. In T2D SMR was 5.6 (30–39 years), 2 (40–59 years), 1.4 (60–69 years), and thereafter no difference. There were no significant sex differences in mortality, and no YLL to adult-onset T1D, but five YLL to T2D for onset at ages 20–60 years. Conclusions: For adult-onset T1D SMR did not differ from the general population, in contrast to previous findings in childhood-onset (&lt; 30 years of age) T1D. The difference in mortality between persons with diabetes and the general population was due to higher mortality in T2D.</p>}},
  author       = {{Thunander, Maria and Lindgren, Anna and Petersson, Christer and Landin-Olsson, Mona and Holmberg, Sara}},
  issn         = {{0168-8227}},
  keywords     = {{C-peptide; Classification; Islet antibodies; Mortality; SMR; Years of life lost}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{Standard mortality rates and years of life lost for serologically defined adult-onset type 1 and type 2 diabetes – A fifteen year follow-up}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2019.107943}},
  doi          = {{10.1016/j.diabres.2019.107943}},
  volume       = {{160}},
  year         = {{2020}},
}