Standard mortality rates and years of life lost for serologically defined adult-onset type 1 and type 2 diabetes – A fifteen year follow-up
(2020) In Diabetes Research and Clinical Practice 160.- Abstract
Aims: The Diabetes Incidence in Kronoberg (DIK) study of adult-onset diabetes used serological classification. Standard Mortality Rates (SMR) and Years of Life Lost (YLL) 15 years after adult-onset (18–100 years) of diabetes were compared to the population of Kronoberg. Methods: Of 1609/1660 (97%) patients, 112 (7%) had type 1 (T1D) (GADA+ and/or ICA+, and/or C-peptide < 0.25 nmol/l), and 1497 (93%) had type 2 diabetes (T2D) (antibody- and C-peptide ≥ 0.25 nmol/l). The National Swedish Mortality Register provided time of death. Results: For T1D SMR did not differ from the Kronoberg population in any age group. In T2D SMR was 1.20 (1.12–1.29). After 15 years 26% (29/112) T1D and 52% (785/1497) T2D... (More)
Aims: The Diabetes Incidence in Kronoberg (DIK) study of adult-onset diabetes used serological classification. Standard Mortality Rates (SMR) and Years of Life Lost (YLL) 15 years after adult-onset (18–100 years) of diabetes were compared to the population of Kronoberg. Methods: Of 1609/1660 (97%) patients, 112 (7%) had type 1 (T1D) (GADA+ and/or ICA+, and/or C-peptide < 0.25 nmol/l), and 1497 (93%) had type 2 diabetes (T2D) (antibody- and C-peptide ≥ 0.25 nmol/l). The National Swedish Mortality Register provided time of death. Results: For T1D SMR did not differ from the Kronoberg population in any age group. In T2D SMR was 1.20 (1.12–1.29). After 15 years 26% (29/112) T1D and 52% (785/1497) T2D patients had died, p < 0.0001. In T2D SMR was 5.6 (30–39 years), 2 (40–59 years), 1.4 (60–69 years), and thereafter no difference. There were no significant sex differences in mortality, and no YLL to adult-onset T1D, but five YLL to T2D for onset at ages 20–60 years. Conclusions: For adult-onset T1D SMR did not differ from the general population, in contrast to previous findings in childhood-onset (< 30 years of age) T1D. The difference in mortality between persons with diabetes and the general population was due to higher mortality in T2D.
(Less)
- author
- Thunander, Maria LU ; Lindgren, Anna LU ; Petersson, Christer ; Landin-Olsson, Mona LU and Holmberg, Sara LU
- organization
- publishing date
- 2020-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C-peptide, Classification, Islet antibodies, Mortality, SMR, Years of life lost
- in
- Diabetes Research and Clinical Practice
- volume
- 160
- article number
- 107943
- publisher
- Elsevier
- external identifiers
-
- scopus:85078045466
- pmid:31765685
- ISSN
- 0168-8227
- DOI
- 10.1016/j.diabres.2019.107943
- language
- English
- LU publication?
- yes
- id
- 5c434ab5-0a35-4365-9f72-49cfc81773b1
- date added to LUP
- 2021-01-13 00:09:10
- date last changed
- 2024-07-25 09:35:38
@article{5c434ab5-0a35-4365-9f72-49cfc81773b1, abstract = {{<p>Aims: The Diabetes Incidence in Kronoberg (DIK) study of adult-onset diabetes used serological classification. Standard Mortality Rates (SMR) and Years of Life Lost (YLL) 15 years after adult-onset (18–100 years) of diabetes were compared to the population of Kronoberg. Methods: Of 1609/1660 (97%) patients, 112 (7%) had type 1 (T1D) (GADA<sup>+</sup> and/or ICA<sup>+</sup>, and/or C-peptide < 0.25 nmol/l), and 1497 (93%) had type 2 diabetes (T2D) (antibody<sup>-</sup> and C-peptide ≥ 0.25 nmol/l). The National Swedish Mortality Register provided time of death. Results: For T1D SMR did not differ from the Kronoberg population in any age group. In T2D SMR was 1.20 (1.12–1.29). After 15 years 26% (29/112) T1D and 52% (785/1497) T2D patients had died, p < 0.0001. In T2D SMR was 5.6 (30–39 years), 2 (40–59 years), 1.4 (60–69 years), and thereafter no difference. There were no significant sex differences in mortality, and no YLL to adult-onset T1D, but five YLL to T2D for onset at ages 20–60 years. Conclusions: For adult-onset T1D SMR did not differ from the general population, in contrast to previous findings in childhood-onset (< 30 years of age) T1D. The difference in mortality between persons with diabetes and the general population was due to higher mortality in T2D.</p>}}, author = {{Thunander, Maria and Lindgren, Anna and Petersson, Christer and Landin-Olsson, Mona and Holmberg, Sara}}, issn = {{0168-8227}}, keywords = {{C-peptide; Classification; Islet antibodies; Mortality; SMR; Years of life lost}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{Standard mortality rates and years of life lost for serologically defined adult-onset type 1 and type 2 diabetes – A fifteen year follow-up}}, url = {{http://dx.doi.org/10.1016/j.diabres.2019.107943}}, doi = {{10.1016/j.diabres.2019.107943}}, volume = {{160}}, year = {{2020}}, }