Endobronchial biopsy positive sarcoidosis: relation to bronchoalveolar lavage and course of disease
(1991) In Respiratory Medicine 85(3). p.229-234- Abstract
- Sixty-two patients with newly diagnosed sarcoidosis were examined with fibreoptic bronchoscopy, endobronchial biopsies and bronchoalveolar lavage (BAL) were analysed. Epithelioid granulomatosis in endobronchial biopsies were found in 28 (45%) of the patients (BPOS). The patients in this BPOS group showed higher inflammatory activity in BAL fluid compared to those with negative biopsies (BNEG), with significant increases in lymphocyte and mast cell counts, and concentrations of procollagen III peptide and albumin. The patients were followed over a period of 2 years. The BPOS group tended to have a worse clinical course with more patients having a progressive disease and more patients requiring treatment with systemic steroids. We conclude... (More)
- Sixty-two patients with newly diagnosed sarcoidosis were examined with fibreoptic bronchoscopy, endobronchial biopsies and bronchoalveolar lavage (BAL) were analysed. Epithelioid granulomatosis in endobronchial biopsies were found in 28 (45%) of the patients (BPOS). The patients in this BPOS group showed higher inflammatory activity in BAL fluid compared to those with negative biopsies (BNEG), with significant increases in lymphocyte and mast cell counts, and concentrations of procollagen III peptide and albumin. The patients were followed over a period of 2 years. The BPOS group tended to have a worse clinical course with more patients having a progressive disease and more patients requiring treatment with systemic steroids. We conclude that the findings of epithelioid granulomatosis in endobronchial biopsies may reflect a more intense and widespread inflammation in the lung. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105689
- author
- Bjermer, Leif LU ; Thunell, M ; Rosenhall, L and Stjernberg, N
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Respiratory Medicine
- volume
- 85
- issue
- 3
- pages
- 229 - 234
- publisher
- Elsevier
- external identifiers
-
- pmid:1882112
- scopus:0025760216
- ISSN
- 1532-3064
- DOI
- 10.1016/S0954-6111(06)80085-5
- language
- English
- LU publication?
- no
- id
- 5c8118e9-d854-4060-89dc-04c6d2541bfc (old id 1105689)
- date added to LUP
- 2016-04-01 17:00:22
- date last changed
- 2021-09-19 04:54:21
@article{5c8118e9-d854-4060-89dc-04c6d2541bfc, abstract = {{Sixty-two patients with newly diagnosed sarcoidosis were examined with fibreoptic bronchoscopy, endobronchial biopsies and bronchoalveolar lavage (BAL) were analysed. Epithelioid granulomatosis in endobronchial biopsies were found in 28 (45%) of the patients (BPOS). The patients in this BPOS group showed higher inflammatory activity in BAL fluid compared to those with negative biopsies (BNEG), with significant increases in lymphocyte and mast cell counts, and concentrations of procollagen III peptide and albumin. The patients were followed over a period of 2 years. The BPOS group tended to have a worse clinical course with more patients having a progressive disease and more patients requiring treatment with systemic steroids. We conclude that the findings of epithelioid granulomatosis in endobronchial biopsies may reflect a more intense and widespread inflammation in the lung.}}, author = {{Bjermer, Leif and Thunell, M and Rosenhall, L and Stjernberg, N}}, issn = {{1532-3064}}, language = {{eng}}, number = {{3}}, pages = {{229--234}}, publisher = {{Elsevier}}, series = {{Respiratory Medicine}}, title = {{Endobronchial biopsy positive sarcoidosis: relation to bronchoalveolar lavage and course of disease}}, url = {{http://dx.doi.org/10.1016/S0954-6111(06)80085-5}}, doi = {{10.1016/S0954-6111(06)80085-5}}, volume = {{85}}, year = {{1991}}, }