Population trends in the incidence and initial management of osteoarthritis : age-period-cohort analysis of the Clinical Practice Research Datalink, 1992-2013
Yu, Dahai ; Jordan, Kelvin P. ; Bedson, John ; Englund, Martin LU
; Blyth, Fiona
; Turkiewicz, Aleksandra
LU
; Prieto-Alhambra, Daniel
and Peat, George
(2017)
In Rheumatology
56(11).
p.1902-1917
- Abstract
Objective: To determine recent trends in the rate and management of new cases of OA presenting to primary healthcare using UK nationally representative data.
Methods: Using the Clinical Practice Research Datalink we identified new cases of diagnosed OA and clinical OA (including OA-relevant peripheral joint pain in those aged over 45 years) using established code lists. For both definitions we estimated annual incidence density using exact person-time, and undertook descriptive analysis and age-period-cohort modelling. Demographic characteristics and management were described for incident cases in each calendar year. Sensitivity analyses explored the robustness of the findings to key assumptions.
Results: Between 1992 and... (More)
Objective: To determine recent trends in the rate and management of new cases of OA presenting to primary healthcare using UK nationally representative data.
Methods: Using the Clinical Practice Research Datalink we identified new cases of diagnosed OA and clinical OA (including OA-relevant peripheral joint pain in those aged over 45 years) using established code lists. For both definitions we estimated annual incidence density using exact person-time, and undertook descriptive analysis and age-period-cohort modelling. Demographic characteristics and management were described for incident cases in each calendar year. Sensitivity analyses explored the robustness of the findings to key assumptions.
Results: Between 1992 and 2013 the annual age-sex standardized incidence rate for clinical OA increased from 29.2 to 40.5/1000 person-years. After controlling for period effects, the consultation incidence of clinical OA was higher for successive cohorts born after the mid-1950s, particularly women. In contrast, with the exception of hand OA, we observed no increase in the incidence of diagnosed OA: 8.6/1000 person-years in 2004 down to 6.3 in 2013. In 2013, 16.4% of clinical OA cases had an X-ray referral. While NSAID prescriptions fell from 2004, the proportion prescribed opioid analgesia rose markedly (0.1% of diagnosed OA in 1992 to 1.9% in 2013).
Conclusion: Rising rates of clinical OA, continued use of plain radiography and a shift towards opioid analgesic prescription are concerning. Our findings support the search for policies to tackle this common problem that promote joint pain prevention while avoiding excessive and inappropriate health care.
(Less)
- author
- Yu, Dahai
; Jordan, Kelvin P.
; Bedson, John
; Englund, Martin
LU
; Blyth, Fiona
; Turkiewicz, Aleksandra
LU
; Prieto-Alhambra, Daniel
and Peat, George
- organization
- publishing date
- 2017-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- analgesics, incidence, osteoarthritis, primary care
- in
- Rheumatology
- volume
- 56
- issue
- 11
- pages
- 16 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85032809102
- pmid:28977564
- wos:000413543900012
- ISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/kex270
- language
- English
- LU publication?
- yes
- id
- 5c85179e-b7ab-4b36-a71b-d6dba4a12e31
- date added to LUP
- 2017-11-22 14:29:52
- date last changed
- 2024-05-13 01:09:55
@article{5c85179e-b7ab-4b36-a71b-d6dba4a12e31,
abstract = {{<p>Objective: To determine recent trends in the rate and management of new cases of OA presenting to primary healthcare using UK nationally representative data.</p><p>Methods: Using the Clinical Practice Research Datalink we identified new cases of diagnosed OA and clinical OA (including OA-relevant peripheral joint pain in those aged over 45 years) using established code lists. For both definitions we estimated annual incidence density using exact person-time, and undertook descriptive analysis and age-period-cohort modelling. Demographic characteristics and management were described for incident cases in each calendar year. Sensitivity analyses explored the robustness of the findings to key assumptions.</p><p>Results: Between 1992 and 2013 the annual age-sex standardized incidence rate for clinical OA increased from 29.2 to 40.5/1000 person-years. After controlling for period effects, the consultation incidence of clinical OA was higher for successive cohorts born after the mid-1950s, particularly women. In contrast, with the exception of hand OA, we observed no increase in the incidence of diagnosed OA: 8.6/1000 person-years in 2004 down to 6.3 in 2013. In 2013, 16.4% of clinical OA cases had an X-ray referral. While NSAID prescriptions fell from 2004, the proportion prescribed opioid analgesia rose markedly (0.1% of diagnosed OA in 1992 to 1.9% in 2013).</p><p>Conclusion: Rising rates of clinical OA, continued use of plain radiography and a shift towards opioid analgesic prescription are concerning. Our findings support the search for policies to tackle this common problem that promote joint pain prevention while avoiding excessive and inappropriate health care.</p>}},
author = {{Yu, Dahai and Jordan, Kelvin P. and Bedson, John and Englund, Martin and Blyth, Fiona and Turkiewicz, Aleksandra and Prieto-Alhambra, Daniel and Peat, George}},
issn = {{1462-0332}},
keywords = {{analgesics; incidence; osteoarthritis; primary care}},
language = {{eng}},
month = {{11}},
number = {{11}},
pages = {{1902--1917}},
publisher = {{Oxford University Press}},
series = {{Rheumatology}},
title = {{Population trends in the incidence and initial management of osteoarthritis : age-period-cohort analysis of the Clinical Practice Research Datalink, 1992-2013}},
url = {{http://dx.doi.org/10.1093/rheumatology/kex270}},
doi = {{10.1093/rheumatology/kex270}},
volume = {{56}},
year = {{2017}},
}