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Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

Arza, Carlos R. LU ; Li, Xiaoya LU ; İlk, Sedef ; Liu, Yang ; Demircan, Deniz LU and Zhang, Baozhong LU (2022) In Journal of Materials Chemistry B 10(39). p.8064-8074
Abstract

This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester... (More)

This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Chemistry B
volume
10
issue
39
pages
11 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:36111601
  • scopus:85139804114
ISSN
2050-750X
DOI
10.1039/d2tb01233b
language
English
LU publication?
yes
id
5caad322-ab2a-419a-a8bf-aabbd56466a9
date added to LUP
2023-01-23 09:47:32
date last changed
2023-03-23 18:16:09
@article{5caad322-ab2a-419a-a8bf-aabbd56466a9,
  abstract     = {{<p>This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.</p>}},
  author       = {{Arza, Carlos R. and Li, Xiaoya and İlk, Sedef and Liu, Yang and Demircan, Deniz and Zhang, Baozhong}},
  issn         = {{2050-750X}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{39}},
  pages        = {{8064--8074}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Journal of Materials Chemistry B}},
  title        = {{Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units}},
  url          = {{http://dx.doi.org/10.1039/d2tb01233b}},
  doi          = {{10.1039/d2tb01233b}},
  volume       = {{10}},
  year         = {{2022}},
}