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Conditioned saccharin avoidance induced by infusion of amphetamine in the nucleus accumbens shell and morphine in the ventral tegmental area : Behavioral and biochemical study

Fenu, Sandro; Espa, E. LU ; Cadoni, Cristina and Di Chiara, Gaetano (2014) In Behavioural Brain Research 269. p.55-60
Abstract

Drugs of abuse possess the seemingly paradoxical property of conditioning rats to avoid from drinking a saccharin solution that had been predictively paired with their systemic administration (conditioned saccharin avoidance, CSA). CSA is dependent upon an intact dopamine (DA) transmission but the locus, central or peripheral, and eventually the brain area from which this effect originates and its relationship with the rewarding properties of the drug is debated. In order to clarify this issue we tested the ability of amphetamine and morphine to induce CSA after infusion at the same dose-range and in the same areas from which these drugs induce conditioned place preference (CPP). Drugs were infused intracerebrally immediately after... (More)

Drugs of abuse possess the seemingly paradoxical property of conditioning rats to avoid from drinking a saccharin solution that had been predictively paired with their systemic administration (conditioned saccharin avoidance, CSA). CSA is dependent upon an intact dopamine (DA) transmission but the locus, central or peripheral, and eventually the brain area from which this effect originates and its relationship with the rewarding properties of the drug is debated. In order to clarify this issue we tested the ability of amphetamine and morphine to induce CSA after infusion at the same dose-range and in the same areas from which these drugs induce conditioned place preference (CPP). Drugs were infused intracerebrally immediately after saccharin drinking in two acquisition trials and CSA was tested on a two bottle saccharin/water choice. Amphetamine (10 and 20. μg/0.5. μl) induced CSA after infusion in the NAc shell but was ineffective in the NAc core. Morphine (0.5 and 1. μg/0.5. μl) induced CSA from the VTA at both doses tested. Amphetamine (20. μg/0.5. μl) and morphine (1. μg/0.5. μl) failed to induce CSA after infusion 1.2. mm dorsal the NAc shell and the VTA respectively. Finally, morphine (1. μg/0.5. μl), infused in the VTA, elicited a selective increase in dialysate DA in the NAc shell. These results indicate that drugs of abuse induce CSA from the same intracerebral sites and at the same doses at which they induce CPP. These observations are consistent with the existence of a strong relationship between CSA and drug reward related to their ability to stimulate DA transmission in the NAc shell.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Conditioned saccharin avoidance, Dopamine, Nucleus accumbens core, Nucleus accumbens shell, Reward, Ventral tegmental area
in
Behavioural Brain Research
volume
269
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:84899791441
ISSN
0166-4328
DOI
10.1016/j.bbr.2014.03.049
language
English
LU publication?
no
id
5cae0e6c-814f-4fde-a483-ab1b6af8202c
date added to LUP
2017-03-29 21:44:51
date last changed
2017-03-30 08:02:29
@article{5cae0e6c-814f-4fde-a483-ab1b6af8202c,
  abstract     = {<p>Drugs of abuse possess the seemingly paradoxical property of conditioning rats to avoid from drinking a saccharin solution that had been predictively paired with their systemic administration (conditioned saccharin avoidance, CSA). CSA is dependent upon an intact dopamine (DA) transmission but the locus, central or peripheral, and eventually the brain area from which this effect originates and its relationship with the rewarding properties of the drug is debated. In order to clarify this issue we tested the ability of amphetamine and morphine to induce CSA after infusion at the same dose-range and in the same areas from which these drugs induce conditioned place preference (CPP). Drugs were infused intracerebrally immediately after saccharin drinking in two acquisition trials and CSA was tested on a two bottle saccharin/water choice. Amphetamine (10 and 20. μg/0.5. μl) induced CSA after infusion in the NAc shell but was ineffective in the NAc core. Morphine (0.5 and 1. μg/0.5. μl) induced CSA from the VTA at both doses tested. Amphetamine (20. μg/0.5. μl) and morphine (1. μg/0.5. μl) failed to induce CSA after infusion 1.2. mm dorsal the NAc shell and the VTA respectively. Finally, morphine (1. μg/0.5. μl), infused in the VTA, elicited a selective increase in dialysate DA in the NAc shell. These results indicate that drugs of abuse induce CSA from the same intracerebral sites and at the same doses at which they induce CPP. These observations are consistent with the existence of a strong relationship between CSA and drug reward related to their ability to stimulate DA transmission in the NAc shell.</p>},
  author       = {Fenu, Sandro and Espa, E. and Cadoni, Cristina and Di Chiara, Gaetano},
  issn         = {0166-4328},
  keyword      = {Conditioned saccharin avoidance,Dopamine,Nucleus accumbens core,Nucleus accumbens shell,Reward,Ventral tegmental area},
  language     = {eng},
  month        = {08},
  pages        = {55--60},
  publisher    = {Elsevier},
  series       = {Behavioural Brain Research},
  title        = {Conditioned saccharin avoidance induced by infusion of amphetamine in the nucleus accumbens shell and morphine in the ventral tegmental area : Behavioral and biochemical study},
  url          = {http://dx.doi.org/10.1016/j.bbr.2014.03.049},
  volume       = {269},
  year         = {2014},
}