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Islet cell and other organ-specific autoantibodies in healthy first-degree relatives to insulin-dependent

Hagglof, B. ; Rabinovitch, A. ; Mackay, P. ; Huen, A. ; Rubenstein, A. H. ; Marner, B. ; Nerup, J. LU and Lernmark, A. LU orcid (1986) In Acta Paediatrica Scandinavica 75(4). p.611-618
Abstract

The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the healthy members in the diabetic families was increased compared to the control families (p < 0.005). Islet cell cytoplasmic antibodies were only detected in diabetes families, since 23% (7/30) of the probands and 7% (2/31) of the siblings were positive and all others negative. Organ-specific autoantibodies were associated with HLA DR3 only... (More)

The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the healthy members in the diabetic families was increased compared to the control families (p < 0.005). Islet cell cytoplasmic antibodies were only detected in diabetes families, since 23% (7/30) of the probands and 7% (2/31) of the siblings were positive and all others negative. Organ-specific autoantibodies were associated with HLA DR3 only in the diabetes families (p < 0.025) while autoantibody positive members in the control families were associated with HLA B7 (P < 0.01). This study suggests that childhood IDDM occurs in families with an increased prevalence of organ-specific autoantibodies.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Acta Paediatrica Scandinavica
volume
75
issue
4
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:3489346
  • scopus:0022575592
ISSN
0001-656X
DOI
10.1111/j.1651-2227.1986.tb10260.x
language
English
LU publication?
no
id
5cf82984-654c-4d3e-96bd-2344a99b9ac2
date added to LUP
2019-09-16 12:33:35
date last changed
2024-03-13 08:21:24
@article{5cf82984-654c-4d3e-96bd-2344a99b9ac2,
  abstract     = {{<p>The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the healthy members in the diabetic families was increased compared to the control families (p &lt; 0.005). Islet cell cytoplasmic antibodies were only detected in diabetes families, since 23% (7/30) of the probands and 7% (2/31) of the siblings were positive and all others negative. Organ-specific autoantibodies were associated with HLA DR3 only in the diabetes families (p &lt; 0.025) while autoantibody positive members in the control families were associated with HLA B7 (P &lt; 0.01). This study suggests that childhood IDDM occurs in families with an increased prevalence of organ-specific autoantibodies.</p>}},
  author       = {{Hagglof, B. and Rabinovitch, A. and Mackay, P. and Huen, A. and Rubenstein, A. H. and Marner, B. and Nerup, J. and Lernmark, A.}},
  issn         = {{0001-656X}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{4}},
  pages        = {{611--618}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica Scandinavica}},
  title        = {{Islet cell and other organ-specific autoantibodies in healthy first-degree relatives to insulin-dependent}},
  url          = {{http://dx.doi.org/10.1111/j.1651-2227.1986.tb10260.x}},
  doi          = {{10.1111/j.1651-2227.1986.tb10260.x}},
  volume       = {{75}},
  year         = {{1986}},
}