Islet cell and other organ-specific autoantibodies in healthy first-degree relatives to insulin-dependent
(1986) In Acta Paediatrica Scandinavica 75(4). p.611-618- Abstract
The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the healthy members in the diabetic families was increased compared to the control families (p < 0.005). Islet cell cytoplasmic antibodies were only detected in diabetes families, since 23% (7/30) of the probands and 7% (2/31) of the siblings were positive and all others negative. Organ-specific autoantibodies were associated with HLA DR3 only... (More)
The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the healthy members in the diabetic families was increased compared to the control families (p < 0.005). Islet cell cytoplasmic antibodies were only detected in diabetes families, since 23% (7/30) of the probands and 7% (2/31) of the siblings were positive and all others negative. Organ-specific autoantibodies were associated with HLA DR3 only in the diabetes families (p < 0.025) while autoantibody positive members in the control families were associated with HLA B7 (P < 0.01). This study suggests that childhood IDDM occurs in families with an increased prevalence of organ-specific autoantibodies.
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- author
- Hagglof, B. ; Rabinovitch, A. ; Mackay, P. ; Huen, A. ; Rubenstein, A. H. ; Marner, B. ; Nerup, J. LU and Lernmark, A. LU
- publishing date
- 1986-09-10
- type
- Contribution to journal
- publication status
- published
- in
- Acta Paediatrica Scandinavica
- volume
- 75
- issue
- 4
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:3489346
- scopus:0022575592
- ISSN
- 0001-656X
- DOI
- 10.1111/j.1651-2227.1986.tb10260.x
- language
- English
- LU publication?
- no
- id
- 5cf82984-654c-4d3e-96bd-2344a99b9ac2
- date added to LUP
- 2019-09-16 12:33:35
- date last changed
- 2024-03-13 08:21:24
@article{5cf82984-654c-4d3e-96bd-2344a99b9ac2, abstract = {{<p>The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the healthy members in the diabetic families was increased compared to the control families (p < 0.005). Islet cell cytoplasmic antibodies were only detected in diabetes families, since 23% (7/30) of the probands and 7% (2/31) of the siblings were positive and all others negative. Organ-specific autoantibodies were associated with HLA DR3 only in the diabetes families (p < 0.025) while autoantibody positive members in the control families were associated with HLA B7 (P < 0.01). This study suggests that childhood IDDM occurs in families with an increased prevalence of organ-specific autoantibodies.</p>}}, author = {{Hagglof, B. and Rabinovitch, A. and Mackay, P. and Huen, A. and Rubenstein, A. H. and Marner, B. and Nerup, J. and Lernmark, A.}}, issn = {{0001-656X}}, language = {{eng}}, month = {{09}}, number = {{4}}, pages = {{611--618}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Paediatrica Scandinavica}}, title = {{Islet cell and other organ-specific autoantibodies in healthy first-degree relatives to insulin-dependent}}, url = {{http://dx.doi.org/10.1111/j.1651-2227.1986.tb10260.x}}, doi = {{10.1111/j.1651-2227.1986.tb10260.x}}, volume = {{75}}, year = {{1986}}, }