Plasma homocysteine, apolipoprotein E status and vascular disease in elderly patients with mental illness.
(2010) In Clinical Chemistry and Laboratory Medicine 48(1). p.129-135- Abstract
- Abstract Background: Total plasma homocysteine (tHcy) concentration is increased in elderly patients with mental illness. Also, patients with vascular disease have significantly higher plasma tHcy concentration compared with patients without vascular disease. Apolipoprotein E (apoE) status is associated with cardiovascular disease and a major genetic risk factor is inheritance of the e4 allele. In the present study, we investigated the association between plasma tHcy and apoE status. Methods: The relation between apoE status, plasma tHcy and vascular disease was investigated in a cohort of consecutively enrolled elderly patients with mental illness (n=328). Results: Plasma tHcy concentrations were increased (p<0.01) in carriers of APOE4... (More)
- Abstract Background: Total plasma homocysteine (tHcy) concentration is increased in elderly patients with mental illness. Also, patients with vascular disease have significantly higher plasma tHcy concentration compared with patients without vascular disease. Apolipoprotein E (apoE) status is associated with cardiovascular disease and a major genetic risk factor is inheritance of the e4 allele. In the present study, we investigated the association between plasma tHcy and apoE status. Methods: The relation between apoE status, plasma tHcy and vascular disease was investigated in a cohort of consecutively enrolled elderly patients with mental illness (n=328). Results: Plasma tHcy concentrations were increased (p<0.01) in carriers of APOE4 (13.6 mumol/L; 9.2-21.7 mumol/L) compared to non-carriers (12.4 mumol/L; 8.3-19.9 mumol/L). The proportion of patients with vascular disease was significantly (p<0.001) increased among carriers (61%) compared to non-carriers (42%). An increased percentage (p<0.001) of APOE4 carriers was observed in patients with Alzheimer's disease (AD) with (71%) or without vascular disease (42%), and in patients with vascular dementia (VaD) (54%) compared to a reference group (34%). Conclusions: Since carriers of APOE4 showed an increased likelihood of vascular disease, these patients need more intensive control of other modifiable vascular risk factors. Furthermore, the association between plasma tHcy and the presence of APOE4 might be attributed to an increased proportion of vascular disease in APOE4 carriers. Clin Chem Lab Med 2010;48. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1524210
- author
- Nilsson, Karin LU ; Gustafson, Lars LU ; Nornholm, Michael and Hultberg, Björn LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Chemistry and Laboratory Medicine
- volume
- 48
- issue
- 1
- pages
- 129 - 135
- publisher
- De Gruyter
- external identifiers
-
- wos:000273908700020
- pmid:19943806
- scopus:74549186458
- ISSN
- 1437-4331
- DOI
- 10.1515/CCLM.2010.013
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- 5d0520cf-9878-4a94-b264-ca6ed4619a88 (old id 1524210)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19943806?dopt=Abstract
- date added to LUP
- 2016-04-04 13:35:48
- date last changed
- 2022-02-06 17:58:56
@article{5d0520cf-9878-4a94-b264-ca6ed4619a88, abstract = {{Abstract Background: Total plasma homocysteine (tHcy) concentration is increased in elderly patients with mental illness. Also, patients with vascular disease have significantly higher plasma tHcy concentration compared with patients without vascular disease. Apolipoprotein E (apoE) status is associated with cardiovascular disease and a major genetic risk factor is inheritance of the e4 allele. In the present study, we investigated the association between plasma tHcy and apoE status. Methods: The relation between apoE status, plasma tHcy and vascular disease was investigated in a cohort of consecutively enrolled elderly patients with mental illness (n=328). Results: Plasma tHcy concentrations were increased (p<0.01) in carriers of APOE4 (13.6 mumol/L; 9.2-21.7 mumol/L) compared to non-carriers (12.4 mumol/L; 8.3-19.9 mumol/L). The proportion of patients with vascular disease was significantly (p<0.001) increased among carriers (61%) compared to non-carriers (42%). An increased percentage (p<0.001) of APOE4 carriers was observed in patients with Alzheimer's disease (AD) with (71%) or without vascular disease (42%), and in patients with vascular dementia (VaD) (54%) compared to a reference group (34%). Conclusions: Since carriers of APOE4 showed an increased likelihood of vascular disease, these patients need more intensive control of other modifiable vascular risk factors. Furthermore, the association between plasma tHcy and the presence of APOE4 might be attributed to an increased proportion of vascular disease in APOE4 carriers. Clin Chem Lab Med 2010;48.}}, author = {{Nilsson, Karin and Gustafson, Lars and Nornholm, Michael and Hultberg, Björn}}, issn = {{1437-4331}}, language = {{eng}}, number = {{1}}, pages = {{129--135}}, publisher = {{De Gruyter}}, series = {{Clinical Chemistry and Laboratory Medicine}}, title = {{Plasma homocysteine, apolipoprotein E status and vascular disease in elderly patients with mental illness.}}, url = {{http://dx.doi.org/10.1515/CCLM.2010.013}}, doi = {{10.1515/CCLM.2010.013}}, volume = {{48}}, year = {{2010}}, }