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Rules of engagement - Regulation of complement response in tissue

Abu-Humaidan, Anas Haider LU (2018)
Abstract
Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.
The work in this thesis aims to answer some of these questions with models that compare healthy and disease states, using methods that investigate complement response in each. The investigation often followed the lines of
queries like: Is complement relevant to this disease state? Is complement activated or its expression induced? If so, through... (More)
Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.
The work in this thesis aims to answer some of these questions with models that compare healthy and disease states, using methods that investigate complement response in each. The investigation often followed the lines of
queries like: Is complement relevant to this disease state? Is complement activated or its expression induced? If so, through what mechanisms? And what local effect could the activation or induced expression have?
Chapter 1 provides an introduction to the complement system that tackles specific topics like complement’s discovery, evolution, function and role in disease. As well as challenges and progress made in complement targeted therapies. Chapter 2 discusses methods and models used in this thesis and in complement research in general. While chapter 3 focuses on the present investigation and where it falls within current knowledge about the local regulation of complement. (Less)
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author
supervisor
opponent
  • professor Molness, Tom Eirik, Faculty of Medicine, Oslo University
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Complement system, Complement activation, Complement regulation, terminal complement complex, Staphylococcus auereus, atopic dermatitis, head and neck cancer, epidermal growth factor receptor, EGFR
pages
46 pages
publisher
Lund University, Faculty of Medicine
defense location
Belfragesalen, BMC D15, Klinikgatan 32 i Lund
defense date
2018-05-31 13:00
ISBN
978-91-7619-657-1
language
English
LU publication?
yes
id
5d1ec1ab-a4d1-4727-a21a-719efaa0f9ac
date added to LUP
2018-05-17 10:19:29
date last changed
2018-05-29 11:39:49
@phdthesis{5d1ec1ab-a4d1-4727-a21a-719efaa0f9ac,
  abstract     = {Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.<br/>The work in this thesis aims to answer some of these questions with models that compare healthy and disease states, using methods that investigate complement response in each. The investigation often followed the lines of<br/>queries like: Is complement relevant to this disease state? Is complement activated or its expression induced? If so, through what mechanisms? And what local effect could the activation or induced expression have?<br/>Chapter 1 provides an introduction to the complement system that tackles specific topics like complement’s discovery, evolution, function and role in disease. As well as challenges and progress made in complement targeted therapies. Chapter 2 discusses methods and models used in this thesis and in complement research in general. While chapter 3 focuses on the present investigation and where it falls within current knowledge about the local regulation of complement.},
  author       = {Abu-Humaidan, Anas Haider},
  isbn         = {978-91-7619-657-1},
  keyword      = {Complement system,Complement activation,Complement regulation,terminal complement complex,Staphylococcus auereus,atopic dermatitis,head and neck cancer,epidermal growth factor receptor,EGFR},
  language     = {eng},
  pages        = {46},
  publisher    = {Lund University, Faculty of Medicine},
  school       = {Lund University},
  title        = {Rules of engagement - Regulation of complement response in tissue},
  year         = {2018},
}