Rules of engagement - Regulation of complement response in tissue
(2018) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2018(91).- Abstract
- Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.
The work in this thesis aims to answer some of these questions with models that compare healthy and disease states, using methods that investigate complement response in each. The investigation often followed the lines of
queries like: Is complement relevant to this disease state? Is complement activated or its expression induced? If so, through... (More) - Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.
The work in this thesis aims to answer some of these questions with models that compare healthy and disease states, using methods that investigate complement response in each. The investigation often followed the lines of
queries like: Is complement relevant to this disease state? Is complement activated or its expression induced? If so, through what mechanisms? And what local effect could the activation or induced expression have?
Chapter 1 provides an introduction to the complement system that tackles specific topics like complement’s discovery, evolution, function and role in disease. As well as challenges and progress made in complement targeted therapies. Chapter 2 discusses methods and models used in this thesis and in complement research in general. While chapter 3 focuses on the present investigation and where it falls within current knowledge about the local regulation of complement. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5d1ec1ab-a4d1-4727-a21a-719efaa0f9ac
- author
- Abu-Humaidan, Anas Haider LU
- supervisor
-
- Ole E Sørensen LU
- Artur Schmidtchen LU
- Arne Egesten LU
- opponent
-
- professor Molness, Tom Eirik, Faculty of Medicine, Oslo University
- organization
- publishing date
- 2018
- type
- Thesis
- publication status
- published
- subject
- keywords
- Complement system, Complement activation, Complement regulation, terminal complement complex, Staphylococcus auereus, atopic dermatitis, head and neck cancer, epidermal growth factor receptor, EGFR
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- volume
- 2018
- issue
- 91
- pages
- 46 pages
- publisher
- Lund University: Faculty of Medicine
- defense location
- Belfragesalen, BMC D15, Klinikgatan 32 i Lund
- defense date
- 2018-05-31 13:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-7619-657-1
- language
- English
- LU publication?
- yes
- additional info
- ISSN: 1652-8220 Lund University, Faculty of Medicine Doctoral Dissertation Series 2018:91
- id
- 5d1ec1ab-a4d1-4727-a21a-719efaa0f9ac
- date added to LUP
- 2018-05-17 10:19:29
- date last changed
- 2019-11-19 13:50:05
@phdthesis{5d1ec1ab-a4d1-4727-a21a-719efaa0f9ac, abstract = {{Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.<br/>The work in this thesis aims to answer some of these questions with models that compare healthy and disease states, using methods that investigate complement response in each. The investigation often followed the lines of<br/>queries like: Is complement relevant to this disease state? Is complement activated or its expression induced? If so, through what mechanisms? And what local effect could the activation or induced expression have?<br/>Chapter 1 provides an introduction to the complement system that tackles specific topics like complement’s discovery, evolution, function and role in disease. As well as challenges and progress made in complement targeted therapies. Chapter 2 discusses methods and models used in this thesis and in complement research in general. While chapter 3 focuses on the present investigation and where it falls within current knowledge about the local regulation of complement.}}, author = {{Abu-Humaidan, Anas Haider}}, isbn = {{978-91-7619-657-1}}, issn = {{1652-8220}}, keywords = {{Complement system; Complement activation; Complement regulation; terminal complement complex; Staphylococcus auereus; atopic dermatitis; head and neck cancer; epidermal growth factor receptor; EGFR}}, language = {{eng}}, number = {{91}}, publisher = {{Lund University: Faculty of Medicine}}, school = {{Lund University}}, series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}}, title = {{Rules of engagement - Regulation of complement response in tissue}}, url = {{https://lup.lub.lu.se/search/files/43255122/Rules_of_engagement._Anas_Haider_Abu_Humaidan_ALL.PDF}}, volume = {{2018}}, year = {{2018}}, }