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High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat

Paul, G LU ; Reum, Torsten; Meissner, Wlodzimierz; Marburger, A; Sohr, Reinhard; Morgenstern, R and Kupsch, A (2000) In NeuroReport 11(3). p.4-441
Abstract

High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences... (More)

High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences striatal dopaminergic metabolism in naive, nonlesioned rats.

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published
keywords
3,4-Dihydroxyphenylacetic Acid, Animals, Corpus Striatum, Dopamine, Electric Stimulation, Extracellular Space, Homovanillic Acid, Male, Movement Disorders, Rats, Rats, Wistar, Subthalamic Nucleus, Journal Article, Research Support, Non-U.S. Gov't
in
NeuroReport
volume
11
issue
3
pages
4 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0033999764
ISSN
0959-4965
language
English
LU publication?
no
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5d4cff13-5210-48f6-9720-2340e63cfe29
date added to LUP
2017-05-18 12:57:07
date last changed
2017-05-22 13:04:24
@article{5d4cff13-5210-48f6-9720-2340e63cfe29,
  abstract     = {<p>High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences striatal dopaminergic metabolism in naive, nonlesioned rats.</p>},
  author       = {Paul, G and Reum, Torsten and Meissner, Wlodzimierz and Marburger, A and Sohr, Reinhard and Morgenstern, R and Kupsch, A},
  issn         = {0959-4965},
  keyword      = {3,4-Dihydroxyphenylacetic Acid,Animals,Corpus Striatum,Dopamine,Electric Stimulation,Extracellular Space,Homovanillic Acid,Male,Movement Disorders,Rats,Rats, Wistar,Subthalamic Nucleus,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {02},
  number       = {3},
  pages        = {4--441},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat},
  volume       = {11},
  year         = {2000},
}