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Patch Testing with Methylchloroisothiazolinone/Methylisothiazolinone Using a New Diagnostic Mix - A Multicenter Study from the International Contact Dermatitis Research Group

Isaksson, Marléne LU ; Andersen, Klaus E. ; Elsner, Peter ; Goh, Chee Leok ; Gonçalo, Margarida ; Goossens, An ; Hadzavdic, Suzana Ljubojevic ; Pratt, Melanie ; Puangpet, Pailin and Sasseville, Denis , et al. (2021) In Dermatitis 32(4). p.220-224
Abstract

Background In the early 1980s, a preservative containing a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a ratio of 3:1 was introduced. This mixture (mix) has been patch tested at 100 ppm (0.01%) worldwide and at 200 ppm (0.02%) in Sweden since 1986 and also in the European baseline series since 2014. Objective A new aqueous mix of MCI 0.015% and MI 0.2% was compared with patch testing with the 2 aqueous baseline preparations of MCI/MI 0.02% and MI 0.2%. Methods Four thousand three hundred ninety-seven patients with dermatitis in 12 International Contact Dermatitis Research Group dermatology departments from 3 continents were patch tested simultaneously with the 3 preparations. Results The frequency of... (More)

Background In the early 1980s, a preservative containing a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a ratio of 3:1 was introduced. This mixture (mix) has been patch tested at 100 ppm (0.01%) worldwide and at 200 ppm (0.02%) in Sweden since 1986 and also in the European baseline series since 2014. Objective A new aqueous mix of MCI 0.015% and MI 0.2% was compared with patch testing with the 2 aqueous baseline preparations of MCI/MI 0.02% and MI 0.2%. Methods Four thousand three hundred ninety-seven patients with dermatitis in 12 International Contact Dermatitis Research Group dermatology departments from 3 continents were patch tested simultaneously with the 3 preparations. Results The frequency of positive patch tests to the allergens varied between 0% and 26.7% in the 12 test centers. The new mixture MCI/MI 0.215% in aqua (aq) detected significantly more patients with MCI/MI allergy than both MCI/MI 0.02% aq (P < 0.001) and MI 0.2% aq (P < 0.001) alone and combined. Conclusions The results favor replacing the preparations MCI/MI 0.02% aq and MI 0.2% aq with the mixture MCI/MI 0.215% aq in the International Contact Dermatitis Research Group baseline series.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
32
issue
4
pages
5 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85110613869
  • pmid:33405484
ISSN
1710-3568
DOI
10.1097/DER.0000000000000657
language
English
LU publication?
yes
id
5d6febe8-8011-401e-a1d4-d33fa5fdab13
date added to LUP
2021-08-23 08:23:53
date last changed
2024-05-19 12:04:28
@article{5d6febe8-8011-401e-a1d4-d33fa5fdab13,
  abstract     = {{<p>Background In the early 1980s, a preservative containing a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a ratio of 3:1 was introduced. This mixture (mix) has been patch tested at 100 ppm (0.01%) worldwide and at 200 ppm (0.02%) in Sweden since 1986 and also in the European baseline series since 2014. Objective A new aqueous mix of MCI 0.015% and MI 0.2% was compared with patch testing with the 2 aqueous baseline preparations of MCI/MI 0.02% and MI 0.2%. Methods Four thousand three hundred ninety-seven patients with dermatitis in 12 International Contact Dermatitis Research Group dermatology departments from 3 continents were patch tested simultaneously with the 3 preparations. Results The frequency of positive patch tests to the allergens varied between 0% and 26.7% in the 12 test centers. The new mixture MCI/MI 0.215% in aqua (aq) detected significantly more patients with MCI/MI allergy than both MCI/MI 0.02% aq (P &lt; 0.001) and MI 0.2% aq (P &lt; 0.001) alone and combined. Conclusions The results favor replacing the preparations MCI/MI 0.02% aq and MI 0.2% aq with the mixture MCI/MI 0.215% aq in the International Contact Dermatitis Research Group baseline series.</p>}},
  author       = {{Isaksson, Marléne and Andersen, Klaus E. and Elsner, Peter and Goh, Chee Leok and Gonçalo, Margarida and Goossens, An and Hadzavdic, Suzana Ljubojevic and Pratt, Melanie and Puangpet, Pailin and Sasseville, Denis and Verma, Kaushal and Bruze, Magnus}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{220--224}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Dermatitis}},
  title        = {{Patch Testing with Methylchloroisothiazolinone/Methylisothiazolinone Using a New Diagnostic Mix - A Multicenter Study from the International Contact Dermatitis Research Group}},
  url          = {{http://dx.doi.org/10.1097/DER.0000000000000657}},
  doi          = {{10.1097/DER.0000000000000657}},
  volume       = {{32}},
  year         = {{2021}},
}