High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D
(2022) In Bioactive Materials 13. p.37-52- Abstract
Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding the need of removal surgery. However, they are not yet routinely applied because their degradation behavior is not fully understood. In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium (Gd) at high resolution. Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4, 8 and 12 weeks. Afterward, the degradation rate and degradation homogeneity, as well as bone-to-implant interface, were studied with synchrotron radiation micro computed tomography and histology. Titanium (Ti)... (More)
Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding the need of removal surgery. However, they are not yet routinely applied because their degradation behavior is not fully understood. In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium (Gd) at high resolution. Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4, 8 and 12 weeks. Afterward, the degradation rate and degradation homogeneity, as well as bone-to-implant interface, were studied with synchrotron radiation micro computed tomography and histology. Titanium (Ti) and polyether ether ketone (PEEK) were used as controls material to evaluate osseointegration. Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd. Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue. The results were correlated to in vitro data obtained from the same material and shape. The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK. The results suggest that both Mg-xGd alloys are suitable as materials for bone implants.
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- author
- Krüger, Diana ; Galli, Silvia ; Zeller-Plumhoff, Berit LU ; Wieland, D. C.Florian ; Peruzzi, Niccolò LU ; Wiese, Björn ; Heuser, Philipp ; Moosmann, Julian ; Wennerberg, Ann and Willumeit-Römer, Regine
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biodegradable implant, Degradation homogeneity, Ex vivo histology, Ex vivo imaging, Histology vs. tomography, Magnesium alloys, Micro-computed tomography degradation rate
- in
- Bioactive Materials
- volume
- 13
- pages
- 37 - 52
- publisher
- Elsevier
- external identifiers
-
- scopus:85119009753
- pmid:35224290
- ISSN
- 2452-199X
- DOI
- 10.1016/j.bioactmat.2021.10.041
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Authors
- id
- 5dc28ec6-7224-4c20-9d12-c6984933c486
- date added to LUP
- 2021-12-03 08:17:32
- date last changed
- 2024-06-15 22:00:32
@article{5dc28ec6-7224-4c20-9d12-c6984933c486,
abstract = {{<p>Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding the need of removal surgery. However, they are not yet routinely applied because their degradation behavior is not fully understood. In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium (Gd) at high resolution. Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4, 8 and 12 weeks. Afterward, the degradation rate and degradation homogeneity, as well as bone-to-implant interface, were studied with synchrotron radiation micro computed tomography and histology. Titanium (Ti) and polyether ether ketone (PEEK) were used as controls material to evaluate osseointegration. Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd. Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue. The results were correlated to in vitro data obtained from the same material and shape. The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK. The results suggest that both Mg-xGd alloys are suitable as materials for bone implants.</p>}},
author = {{Krüger, Diana and Galli, Silvia and Zeller-Plumhoff, Berit and Wieland, D. C.Florian and Peruzzi, Niccolò and Wiese, Björn and Heuser, Philipp and Moosmann, Julian and Wennerberg, Ann and Willumeit-Römer, Regine}},
issn = {{2452-199X}},
keywords = {{Biodegradable implant; Degradation homogeneity; Ex vivo histology; Ex vivo imaging; Histology vs. tomography; Magnesium alloys; Micro-computed tomography degradation rate}},
language = {{eng}},
pages = {{37--52}},
publisher = {{Elsevier}},
series = {{Bioactive Materials}},
title = {{High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D}},
url = {{http://dx.doi.org/10.1016/j.bioactmat.2021.10.041}},
doi = {{10.1016/j.bioactmat.2021.10.041}},
volume = {{13}},
year = {{2022}},
}