Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase

Kashyap, Maneesh ; Das, Dipon ; Preet, Ranjan ; Mohapatra, Purusottam LU ; Satapathy, Shakti Ranjan LU ; Siddharth, Sumit ; Kundu, Chanakya N and Guchhait, Sankar K (2012) In Bioorganic & Medicinal Chemistry Letters 22(7). p.9-2474
Abstract

Scaffold hybridization of several natural and synthetic anticancer leads led to the consideration of indenoindolones as potential novel anticancer agents. A series of these compounds were prepared by a diversity-feasible synthetic method. They were found to possess anticancer activities with higher potency compared to etoposide and 5-fluorouracil in kidney cancer cells (HEK 293) and low toxicity to corresponding normal cells (Vero). They exerted apoptotic effect with blocking of cell cycle at G2/M phase.

Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Antineoplastic Agents/chemical synthesis, Apoptosis/drug effects, Biomarkers/metabolism, Cell Survival/drug effects, Chlorocebus aethiops, Etoposide/pharmacology, Flow Cytometry, Fluorouracil/pharmacology, G2 Phase Cell Cycle Checkpoints/drug effects, HEK293 Cells, Humans, Indenes/chemical synthesis, Indoles/chemical synthesis, Inhibitory Concentration 50, Vero Cells
in
Bioorganic & Medicinal Chemistry Letters
volume
22
issue
7
pages
9 - 2474
publisher
Elsevier
external identifiers
  • pmid:22381050
  • scopus:84858709629
ISSN
0960-894X
DOI
10.1016/j.bmcl.2012.02.007
language
English
LU publication?
no
additional info
Copyright © 2012 Elsevier Ltd. All rights reserved.
id
5dd42054-2ef6-46df-adb0-aba08218995a
date added to LUP
2025-01-30 10:30:38
date last changed
2025-05-09 10:54:50
@article{5dd42054-2ef6-46df-adb0-aba08218995a,
  abstract     = {{<p>Scaffold hybridization of several natural and synthetic anticancer leads led to the consideration of indenoindolones as potential novel anticancer agents. A series of these compounds were prepared by a diversity-feasible synthetic method. They were found to possess anticancer activities with higher potency compared to etoposide and 5-fluorouracil in kidney cancer cells (HEK 293) and low toxicity to corresponding normal cells (Vero). They exerted apoptotic effect with blocking of cell cycle at G2/M phase.</p>}},
  author       = {{Kashyap, Maneesh and Das, Dipon and Preet, Ranjan and Mohapatra, Purusottam and Satapathy, Shakti Ranjan and Siddharth, Sumit and Kundu, Chanakya N and Guchhait, Sankar K}},
  issn         = {{0960-894X}},
  keywords     = {{Animals; Antineoplastic Agents/chemical synthesis; Apoptosis/drug effects; Biomarkers/metabolism; Cell Survival/drug effects; Chlorocebus aethiops; Etoposide/pharmacology; Flow Cytometry; Fluorouracil/pharmacology; G2 Phase Cell Cycle Checkpoints/drug effects; HEK293 Cells; Humans; Indenes/chemical synthesis; Indoles/chemical synthesis; Inhibitory Concentration 50; Vero Cells}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{7}},
  pages        = {{9--2474}},
  publisher    = {{Elsevier}},
  series       = {{Bioorganic & Medicinal Chemistry Letters}},
  title        = {{Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase}},
  url          = {{http://dx.doi.org/10.1016/j.bmcl.2012.02.007}},
  doi          = {{10.1016/j.bmcl.2012.02.007}},
  volume       = {{22}},
  year         = {{2012}},
}