Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

Biram, Adi ; Liu, Jingjing ; Hezroni, Hadas ; Davidzohn, Natalia ; Schmiedel, Dominik ; Khatib-Massalha, Eman ; Haddad, Montaser ; Grenov, Amalie ; Lebon, Sacha and Salame, Tomer Meir , et al. (2022) In Immunity 55(3). p.8-458
Abstract

Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary invading pathogens. We demonstrated that recruitment of Sca-1 + monocytes into lymphoid organs during Salmonella Typhimurium (STm) infection disrupted pre-existing germinal center (GC) reactions. GC responses induced by influenza, plasmodium, or commensals deteriorated following STm infection. GC disruption was independent of the direct bacterial interactions with B cells and instead was induced through recruitment of CCR2-dependent Sca-1 + monocytes into the lymphoid organs. GC collapse was... (More)

Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary invading pathogens. We demonstrated that recruitment of Sca-1 + monocytes into lymphoid organs during Salmonella Typhimurium (STm) infection disrupted pre-existing germinal center (GC) reactions. GC responses induced by influenza, plasmodium, or commensals deteriorated following STm infection. GC disruption was independent of the direct bacterial interactions with B cells and instead was induced through recruitment of CCR2-dependent Sca-1 + monocytes into the lymphoid organs. GC collapse was associated with impaired cellular respiration and was dependent on TNFα and IFNγ, the latter of which was essential for Sca-1 + monocyte differentiation. Monocyte recruitment and GC disruption also occurred during LPS-supplemented vaccination and Listeria monocytogenes infection. Thus, systemic activation of the innate immune response upon severe bacterial infection is induced at the expense of antibody-mediated immunity.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
subject
keywords
B-Lymphocytes, Bacterial Infections, Germinal Center, Humans, Listeriosis, Monocytes
in
Immunity
volume
55
issue
3
pages
8 - 458
publisher
Cell Press
external identifiers
  • scopus:85125657482
  • pmid:35182483
ISSN
1074-7613
DOI
10.1016/j.immuni.2022.01.013
language
English
LU publication?
no
additional info
Copyright © 2022 Elsevier Inc. All rights reserved.
id
5ddbd4d6-a0ec-4558-ba1b-5596edc6d3ea
date added to LUP
2023-11-16 12:47:03
date last changed
2024-04-29 18:23:15
@article{5ddbd4d6-a0ec-4558-ba1b-5596edc6d3ea,
  abstract     = {{<p>Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary invading pathogens. We demonstrated that recruitment of Sca-1 + monocytes into lymphoid organs during Salmonella Typhimurium (STm) infection disrupted pre-existing germinal center (GC) reactions. GC responses induced by influenza, plasmodium, or commensals deteriorated following STm infection. GC disruption was independent of the direct bacterial interactions with B cells and instead was induced through recruitment of CCR2-dependent Sca-1 + monocytes into the lymphoid organs. GC collapse was associated with impaired cellular respiration and was dependent on TNFα and IFNγ, the latter of which was essential for Sca-1 + monocyte differentiation. Monocyte recruitment and GC disruption also occurred during LPS-supplemented vaccination and Listeria monocytogenes infection. Thus, systemic activation of the innate immune response upon severe bacterial infection is induced at the expense of antibody-mediated immunity. </p>}},
  author       = {{Biram, Adi and Liu, Jingjing and Hezroni, Hadas and Davidzohn, Natalia and Schmiedel, Dominik and Khatib-Massalha, Eman and Haddad, Montaser and Grenov, Amalie and Lebon, Sacha and Salame, Tomer Meir and Dezorella, Nili and Hoffman, Dotan and Abou Karam, Paula and Biton, Moshe and Lapidot, Tsvee and Bemark, Mats and Avraham, Roi and Jung, Steffen and Shulman, Ziv}},
  issn         = {{1074-7613}},
  keywords     = {{B-Lymphocytes; Bacterial Infections; Germinal Center; Humans; Listeriosis; Monocytes}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{8--458}},
  publisher    = {{Cell Press}},
  series       = {{Immunity}},
  title        = {{Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation}},
  url          = {{http://dx.doi.org/10.1016/j.immuni.2022.01.013}},
  doi          = {{10.1016/j.immuni.2022.01.013}},
  volume       = {{55}},
  year         = {{2022}},
}