Delivery of cellular factors to regulate bone healing
Haumer, Alexander ; Bourgine, Paul Emile LU
; Occhetta, Paola
; Born, Gordian
; Tasso, Roberta
and Martin, Ivan
(2018)
In Advanced Drug Delivery Reviews
129.
p.285-294
- Abstract
- Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytokines/morphogens, indicate the potential of ‘orthobiologics’, but are not fully satisfactory. Here, we review different approaches based on the delivery of regenerative cues produced by cells but in cell-free, possibly off-the-shelf configurations. Such strategies exploit the paracrine effect of the secretome of mesenchymal stem/stromal cells,... (More)
- Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytokines/morphogens, indicate the potential of ‘orthobiologics’, but are not fully satisfactory. Here, we review different approaches based on the delivery of regenerative cues produced by cells but in cell-free, possibly off-the-shelf configurations. Such strategies exploit the paracrine effect of the secretome of mesenchymal stem/stromal cells, presented in soluble form, shuttled through extracellular vesicles, or embedded within the network of extracellular matrix molecules. In addition to osteoinductive molecules, attention is given to factors targeting the resident immune cells, to reshape inflammatory and immunity processes from scarring to regenerative patterns. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5deb011e-da3f-47e7-83d3-1e2effb89919
- author
- Haumer, Alexander
; Bourgine, Paul Emile
LU
; Occhetta, Paola
; Born, Gordian
; Tasso, Roberta
and Martin, Ivan
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- in
- Advanced Drug Delivery Reviews
- volume
- 129
- pages
- 285 - 294
- publisher
- Elsevier
- external identifiers
-
- scopus:85040643290
- ISSN
- 0169-409X
- DOI
- 10.1016/j.addr.2018.01.010
- language
- English
- LU publication?
- no
- id
- 5deb011e-da3f-47e7-83d3-1e2effb89919
- date added to LUP
- 2022-02-09 19:16:22
- date last changed
- 2022-04-28 00:16:48
@article{5deb011e-da3f-47e7-83d3-1e2effb89919,
abstract = {{Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytokines/morphogens, indicate the potential of ‘orthobiologics’, but are not fully satisfactory. Here, we review different approaches based on the delivery of regenerative cues produced by cells but in cell-free, possibly off-the-shelf configurations. Such strategies exploit the paracrine effect of the secretome of mesenchymal stem/stromal cells, presented in soluble form, shuttled through extracellular vesicles, or embedded within the network of extracellular matrix molecules. In addition to osteoinductive molecules, attention is given to factors targeting the resident immune cells, to reshape inflammatory and immunity processes from scarring to regenerative patterns.}},
author = {{Haumer, Alexander and Bourgine, Paul Emile and Occhetta, Paola and Born, Gordian and Tasso, Roberta and Martin, Ivan}},
issn = {{0169-409X}},
language = {{eng}},
pages = {{285--294}},
publisher = {{Elsevier}},
series = {{Advanced Drug Delivery Reviews}},
title = {{Delivery of cellular factors to regulate bone healing}},
url = {{http://dx.doi.org/10.1016/j.addr.2018.01.010}},
doi = {{10.1016/j.addr.2018.01.010}},
volume = {{129}},
year = {{2018}},
}