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Imaging brain microstructure with diffusion MRI : Practicality and applications

Alexander, Daniel C.; Dyrby, Tim B.; Nilsson, Markus LU and Zhang, Hui (2017) In NMR in Biomedicine
Abstract

This article gives an overview of microstructure imaging of the brain with diffusion MRI and reviews the state of the art. The microstructure-imaging paradigm aims to estimate and map microscopic properties of tissue using a model that links these properties to the voxel scale MR signal. Imaging techniques of this type are just starting to make the transition from the technical research domain to wide application in biomedical studies. We focus here on the practicalities of both implementing such techniques and using them in applications. Specifically, the article summarizes the relevant aspects of brain microanatomy and the range of diffusion-weighted MR measurements that provide sensitivity to them. It then reviews the evolution of... (More)

This article gives an overview of microstructure imaging of the brain with diffusion MRI and reviews the state of the art. The microstructure-imaging paradigm aims to estimate and map microscopic properties of tissue using a model that links these properties to the voxel scale MR signal. Imaging techniques of this type are just starting to make the transition from the technical research domain to wide application in biomedical studies. We focus here on the practicalities of both implementing such techniques and using them in applications. Specifically, the article summarizes the relevant aspects of brain microanatomy and the range of diffusion-weighted MR measurements that provide sensitivity to them. It then reviews the evolution of mathematical and computational models that relate the diffusion MR signal to brain tissue microstructure, as well as the expanding areas of application. Next we focus on practicalities of designing a working microstructure imaging technique: model selection, experiment design, parameter estimation, validation, and the pipeline of development of this class of technique. The article concludes with some future perspectives on opportunities in this topic and expectations on how the field will evolve in the short-to-medium term.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Brain, Diffusion MRI, Magnetic resonance imaging, Microstructure imaging, Neuroimaging, Quantitative imaging, Virtual histology
in
NMR in Biomedicine
publisher
John Wiley & Sons
external identifiers
  • scopus:85036579586
ISSN
0952-3480
DOI
10.1002/nbm.3841
language
English
LU publication?
yes
id
5df41ae0-438a-4470-b23b-e3f97a5c5c97
date added to LUP
2018-01-10 12:40:09
date last changed
2018-04-29 04:45:01
@article{5df41ae0-438a-4470-b23b-e3f97a5c5c97,
  abstract     = {<p>This article gives an overview of microstructure imaging of the brain with diffusion MRI and reviews the state of the art. The microstructure-imaging paradigm aims to estimate and map microscopic properties of tissue using a model that links these properties to the voxel scale MR signal. Imaging techniques of this type are just starting to make the transition from the technical research domain to wide application in biomedical studies. We focus here on the practicalities of both implementing such techniques and using them in applications. Specifically, the article summarizes the relevant aspects of brain microanatomy and the range of diffusion-weighted MR measurements that provide sensitivity to them. It then reviews the evolution of mathematical and computational models that relate the diffusion MR signal to brain tissue microstructure, as well as the expanding areas of application. Next we focus on practicalities of designing a working microstructure imaging technique: model selection, experiment design, parameter estimation, validation, and the pipeline of development of this class of technique. The article concludes with some future perspectives on opportunities in this topic and expectations on how the field will evolve in the short-to-medium term.</p>},
  author       = {Alexander, Daniel C. and Dyrby, Tim B. and Nilsson, Markus and Zhang, Hui},
  issn         = {0952-3480},
  keyword      = {Brain,Diffusion MRI,Magnetic resonance imaging,Microstructure imaging,Neuroimaging,Quantitative imaging,Virtual histology},
  language     = {eng},
  publisher    = {John Wiley & Sons},
  series       = {NMR in Biomedicine},
  title        = {Imaging brain microstructure with diffusion MRI : Practicality and applications},
  url          = {http://dx.doi.org/10.1002/nbm.3841},
  year         = {2017},
}