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Evaluation of changes in Bone Scan Index at different acquisition time-points in bone scintigraphy

Kaboteh, Reza; Minarik, David LU ; Reza, Mariana LU ; Sadik, May and Trägårdh, Elin LU (2018) In Clinical Physiology and Functional Imaging 38(6). p.1015-1020
Abstract

Bone Scan Index (BSI) is a validated imaging biomarker to objectively assess tumour burden in bone in patients with prostate cancer, and can be used to monitor treatment response. It is not known if BSI is significantly altered when images are acquired at a time difference of 1 h. The aim of this study was to investigate if automatic calculation of BSI is affected when images are acquired 1 hour apart, after approximately 3 and 4 h. We prospectively studied patients with prostate cancer who were referred for bone scintigraphy according to clinical routine. The patients performed a whole-body bone scan at approximately 3 h after injection of radiolabelled bisphosphonate and a second 1 h after the first. BSI values for each bone... (More)

Bone Scan Index (BSI) is a validated imaging biomarker to objectively assess tumour burden in bone in patients with prostate cancer, and can be used to monitor treatment response. It is not known if BSI is significantly altered when images are acquired at a time difference of 1 h. The aim of this study was to investigate if automatic calculation of BSI is affected when images are acquired 1 hour apart, after approximately 3 and 4 h. We prospectively studied patients with prostate cancer who were referred for bone scintigraphy according to clinical routine. The patients performed a whole-body bone scan at approximately 3 h after injection of radiolabelled bisphosphonate and a second 1 h after the first. BSI values for each bone scintigraphy were obtained using EXINI boneBSI software. A total of 25 patients were included. Median BSI for the first acquisition was 0·05 (range 0-11·93) and for the second acquisition 0·21 (range 0-13·06). There was a statistically significant increase in BSI at the second image acquisition compared to the first (P<0·001). In seven of 25 patients (28%) and in seven of 13 patients with BSI > 0 (54%), a clinically significant increase (>0·3) was observed. The time between injection and scanning should be fixed when changes in BSI are important, for example when monitoring therapeutic efficacy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone metastases, Bone scan quantitative analysis, Computer-assisted diagnostic software, Imaging biomarker, Prostate cancer, Reproducibility
in
Clinical Physiology and Functional Imaging
volume
38
issue
6
pages
1015 - 1020
publisher
Wiley Online Library
external identifiers
  • scopus:85045222244
ISSN
1475-0961
DOI
10.1111/cpf.12518
language
English
LU publication?
yes
id
5dfff38d-8969-427b-9a28-d083c01787c1
date added to LUP
2018-04-23 10:17:23
date last changed
2019-02-20 11:14:54
@article{5dfff38d-8969-427b-9a28-d083c01787c1,
  abstract     = {<p>Bone Scan Index (BSI) is a validated imaging biomarker to objectively assess tumour burden in bone in patients with prostate cancer, and can be used to monitor treatment response. It is not known if BSI is significantly altered when images are acquired at a time difference of 1 h. The aim of this study was to investigate if automatic calculation of BSI is affected when images are acquired 1 hour apart, after approximately 3 and 4 h. We prospectively studied patients with prostate cancer who were referred for bone scintigraphy according to clinical routine. The patients performed a whole-body bone scan at approximately 3 h after injection of radiolabelled bisphosphonate and a second 1 h after the first. BSI values for each bone scintigraphy were obtained using EXINI bone<sup>BSI</sup> software. A total of 25 patients were included. Median BSI for the first acquisition was 0·05 (range 0-11·93) and for the second acquisition 0·21 (range 0-13·06). There was a statistically significant increase in BSI at the second image acquisition compared to the first (P&lt;0·001). In seven of 25 patients (28%) and in seven of 13 patients with BSI &gt; 0 (54%), a clinically significant increase (&gt;0·3) was observed. The time between injection and scanning should be fixed when changes in BSI are important, for example when monitoring therapeutic efficacy.</p>},
  author       = {Kaboteh, Reza and Minarik, David and Reza, Mariana and Sadik, May and Trägårdh, Elin},
  issn         = {1475-0961},
  keyword      = {Bone metastases,Bone scan quantitative analysis,Computer-assisted diagnostic software,Imaging biomarker,Prostate cancer,Reproducibility},
  language     = {eng},
  number       = {6},
  pages        = {1015--1020},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Evaluation of changes in Bone Scan Index at different acquisition time-points in bone scintigraphy},
  url          = {http://dx.doi.org/10.1111/cpf.12518},
  volume       = {38},
  year         = {2018},
}