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Preclinical models of levodopa-induced dyskinesia

Francardo, Veronica LU and Cenci, M. Angela LU (2014) In Levodopa-Induced Dyskinesia in Parkinson's Disease p.335-353
Abstract

L -DOPA-induced dyskinesia (LID) represents one of the major limitations in the current pharmacotherapy of Parkinson's disease (PD) and affects the majority of PD patients. Animal models are the most important preclinical tool for molecular investigations of LID mechanisms and therapeutic targets. Over the last two decades, models of LID have been developed in both nonhuman primate and rodent species, recapitulating several aspects of the human dyskinesia. This chapter will review and compare the main features of the rodent and nonprimate models of LID currently available and summarize some of the main neurobiological fi ndings obtained from these models.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
6-hydroxydopamine, Abnormal involuntary movements, Animal models, L -DOPA-induced dyskinesia, MPTP, Parkinson's disease
in
Levodopa-Induced Dyskinesia in Parkinson's Disease
editor
Fox, Susan H.; Brotchie, Jonathan M.; and
pages
19 pages
publisher
Springer-Verlag London Ltd
external identifiers
  • scopus:84930153045
ISBN
1447165020
9781447165026
9781447165033
DOI
10.1007/978-1-4471-6503-3_18
language
English
LU publication?
yes
id
5e03906b-c63e-4080-856a-15775a9741c5
date added to LUP
2017-04-24 12:45:05
date last changed
2017-04-24 12:45:05
@inbook{5e03906b-c63e-4080-856a-15775a9741c5,
  abstract     = {<p>L -DOPA-induced dyskinesia (LID) represents one of the major limitations in the current pharmacotherapy of Parkinson's disease (PD) and affects the majority of PD patients. Animal models are the most important preclinical tool for molecular investigations of LID mechanisms and therapeutic targets. Over the last two decades, models of LID have been developed in both nonhuman primate and rodent species, recapitulating several aspects of the human dyskinesia. This chapter will review and compare the main features of the rodent and nonprimate models of LID currently available and summarize some of the main neurobiological fi ndings obtained from these models.</p>},
  author       = {Francardo, Veronica and Cenci, M. Angela},
  editor       = {Fox, Susan H. and Brotchie, Jonathan M.},
  isbn         = {1447165020},
  keyword      = {6-hydroxydopamine,Abnormal involuntary movements,Animal models,L -DOPA-induced dyskinesia,MPTP,Parkinson's disease},
  language     = {eng},
  pages        = {335--353},
  publisher    = {Springer-Verlag London Ltd},
  series       = {Levodopa-Induced Dyskinesia in Parkinson's Disease},
  title        = {Preclinical models of levodopa-induced dyskinesia},
  url          = {http://dx.doi.org/10.1007/978-1-4471-6503-3_18},
  year         = {2014},
}