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Fracture behavior of a composite of bone and calcium sulfate/hydroxyapatite

Kok, Joeri LU orcid ; Törnquist, Elin LU ; Raina, Deepak Bushan LU ; Le Cann, Sophie LU ; Novak, Vladimir ; Širka, Aurimas ; Lidgren, Lars LU ; Grassi, Lorenzo LU orcid and Isaksson, Hanna LU orcid (2022) In Journal of the Mechanical Behavior of Biomedical Materials 130.
Abstract

Calcium sulfate/hydroxyapatite (CaS/HA) biomaterials have been investigated for use in several orthopedic applications. However, the mechanical interactions between the composite of CaS/HA and bone at the microscale are still unknown. The aim of this study was to determine if and how augmentation with CaS/HA alters the fracture behavior of bone. Eleven cylinders of trabecular bone were drilled from human femoral heads and cleaned from bone marrow. Among them, five cylinders were injected with CaS/HA to generate composite specimens, while the others were kept intact. One extra specimen of pure CaS/HA was prepared. All specimens were compressed in situ using synchrotron X-ray tomography and imaged at ∼2% strain intervals. Structural... (More)

Calcium sulfate/hydroxyapatite (CaS/HA) biomaterials have been investigated for use in several orthopedic applications. However, the mechanical interactions between the composite of CaS/HA and bone at the microscale are still unknown. The aim of this study was to determine if and how augmentation with CaS/HA alters the fracture behavior of bone. Eleven cylinders of trabecular bone were drilled from human femoral heads and cleaned from bone marrow. Among them, five cylinders were injected with CaS/HA to generate composite specimens, while the others were kept intact. One extra specimen of pure CaS/HA was prepared. All specimens were compressed in situ using synchrotron X-ray tomography and imaged at ∼2% strain intervals. Structural properties were calculated from the images in unloaded state and mechanical properties were determined from the load-curves. CaS/HA alone displayed the highest peak force and stiffness and the lowest strain at fracture. All composite specimens had a higher peak force than the pure bone specimens and the composite specimens had higher toughness than the pure CaS/HA specimen. Furthermore, the fracture behavior was analyzed further to characterize the local deformations. The pure bone specimens presented damage in multiple trabeculae and the CaS/HA specimen displayed sharp transition in strains, with low strain in one load step and large cracks in the next. The composite specimens deformed uniformly, with the CaS/HA preventing tissue damage and the bone preventing cracks in the CaS/HA from propagating through the specimen. In conclusion, using tomography with in situ loading, it was possible to show how CaS/HA can help prevent bone tissue damage before global failure.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomaterial, bone cement, x-ray tomography, synchrotron, in situ loading, Bone damage
in
Journal of the Mechanical Behavior of Biomedical Materials
volume
130
article number
105201
pages
9 pages
publisher
Elsevier
external identifiers
  • pmid:35385809
  • scopus:85127306921
ISSN
1751-6161
DOI
10.1016/j.jmbbm.2022.105201
language
English
LU publication?
yes
id
5e50a83d-1e5f-46b4-81e4-3ad387a802cd
date added to LUP
2022-04-07 21:13:40
date last changed
2024-04-25 12:16:11
@article{5e50a83d-1e5f-46b4-81e4-3ad387a802cd,
  abstract     = {{<p>Calcium sulfate/hydroxyapatite (CaS/HA) biomaterials have been investigated for use in several orthopedic applications. However, the mechanical interactions between the composite of CaS/HA and bone at the microscale are still unknown. The aim of this study was to determine if and how augmentation with CaS/HA alters the fracture behavior of bone. Eleven cylinders of trabecular bone were drilled from human femoral heads and cleaned from bone marrow. Among them, five cylinders were injected with CaS/HA to generate composite specimens, while the others were kept intact. One extra specimen of pure CaS/HA was prepared. All specimens were compressed in situ using synchrotron X-ray tomography and imaged at ∼2% strain intervals. Structural properties were calculated from the images in unloaded state and mechanical properties were determined from the load-curves. CaS/HA alone displayed the highest peak force and stiffness and the lowest strain at fracture. All composite specimens had a higher peak force than the pure bone specimens and the composite specimens had higher toughness than the pure CaS/HA specimen. Furthermore, the fracture behavior was analyzed further to characterize the local deformations. The pure bone specimens presented damage in multiple trabeculae and the CaS/HA specimen displayed sharp transition in strains, with low strain in one load step and large cracks in the next. The composite specimens deformed uniformly, with the CaS/HA preventing tissue damage and the bone preventing cracks in the CaS/HA from propagating through the specimen. In conclusion, using tomography with in situ loading, it was possible to show how CaS/HA can help prevent bone tissue damage before global failure.</p>}},
  author       = {{Kok, Joeri and Törnquist, Elin and Raina, Deepak Bushan and Le Cann, Sophie and Novak, Vladimir and Širka, Aurimas and Lidgren, Lars and Grassi, Lorenzo and Isaksson, Hanna}},
  issn         = {{1751-6161}},
  keywords     = {{Biomaterial; bone cement; x-ray tomography; synchrotron; in situ loading; Bone damage}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Journal of the Mechanical Behavior of Biomedical Materials}},
  title        = {{Fracture behavior of a composite of bone and calcium sulfate/hydroxyapatite}},
  url          = {{http://dx.doi.org/10.1016/j.jmbbm.2022.105201}},
  doi          = {{10.1016/j.jmbbm.2022.105201}},
  volume       = {{130}},
  year         = {{2022}},
}