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Patient Characteristics and General Practitioners’ Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries

van der Ploeg, M. A.; Petrazzuoli, Ferdinando LU ; Thulesius, Hans LU ; Poortvliet, Rosalinde K.E. and , (2019) In Journal of General Internal Medicine
Abstract
Background: Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners’ (GPs) advice to stop statins in oldest-old patients. Objective: To investigate the influence of a history of CVD, statin-related side effects, frailty and short life expectancy, on GPs’ advice to stop statins in oldest-old patients. Design: We invited GPs to participate in this case-based survey. GPs were presented with 8 case vignettes describing patients > 80 years using a statin, and asked whether they would advise stopping statin treatment. Main Measures: Cases varied in history of CVD, statin-related side effects and... (More)
Background: Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners’ (GPs) advice to stop statins in oldest-old patients. Objective: To investigate the influence of a history of CVD, statin-related side effects, frailty and short life expectancy, on GPs’ advice to stop statins in oldest-old patients. Design: We invited GPs to participate in this case-based survey. GPs were presented with 8 case vignettes describing patients > 80 years using a statin, and asked whether they would advise stopping statin treatment. Main Measures: Cases varied in history of CVD, statin-related side effects and frailty, with and without shortened life expectancy (< 1 year) in the context of metastatic, non-curable cancer. Odds ratios adjusted for GP characteristics (ORadj) were calculated for GPs’ advice to stop. Key Results: Two thousand two hundred fifty GPs from 30 countries participated (median response rate 36%). Overall, GPs advised stopping statin treatment in 46% (95%CI 45–47) of the case vignettes; with shortened life expectancy, this proportion increased to 90% (95CI% 89–90). Advice to stop was more frequent in case vignettes without CVD compared to those with CVD (ORadj 13.8, 95%CI 12.6–15.1), with side effects compared to without ORadj 1.62 (95%CI 1.5–1.7) and with frailty (ORadj 4.1, 95%CI 3.8–4.4) compared to without. Shortened life expectancy increased advice to stop (ORadj 50.7, 95%CI 45.5–56.4) and was the strongest predictor for GP advice to stop, ranging across countries from 30% (95%CI 19–42) to 98% (95% CI 96–99). Conclusions: The absence of CVD, the presence of statin-related side effects, and frailty were all independently associated with GPs’ advice to stop statins in patients aged > 80 years. Overall, and within all countries, cancer-related short life expectancy was the strongest independent predictor of GPs’ advice to stop statins. © 2019, The Author(s). (Less)
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organization
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type
Contribution to journal
publication status
epub
subject
keywords
cardiovascular diseases, clinical decision-making, drug therapy, general practitioners, hydroxymethylglutaryl-CoA reductase inhibitors, palliative care
in
Journal of General Internal Medicine
publisher
Springer New York
external identifiers
  • scopus:85060148045
ISSN
0884-8734
DOI
10.1007/s11606-018-4795-x
language
English
LU publication?
yes
id
5e6fa70d-6c6d-4f2c-8276-e9c19d522416
date added to LUP
2019-04-10 12:49:17
date last changed
2019-04-14 04:09:43
@article{5e6fa70d-6c6d-4f2c-8276-e9c19d522416,
  abstract     = {Background: Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners’ (GPs) advice to stop statins in oldest-old patients. Objective: To investigate the influence of a history of CVD, statin-related side effects, frailty and short life expectancy, on GPs’ advice to stop statins in oldest-old patients. Design: We invited GPs to participate in this case-based survey. GPs were presented with 8 case vignettes describing patients &gt; 80 years using a statin, and asked whether they would advise stopping statin treatment. Main Measures: Cases varied in history of CVD, statin-related side effects and frailty, with and without shortened life expectancy (&lt; 1 year) in the context of metastatic, non-curable cancer. Odds ratios adjusted for GP characteristics (ORadj) were calculated for GPs’ advice to stop. Key Results: Two thousand two hundred fifty GPs from 30 countries participated (median response rate 36%). Overall, GPs advised stopping statin treatment in 46% (95%CI 45–47) of the case vignettes; with shortened life expectancy, this proportion increased to 90% (95CI% 89–90). Advice to stop was more frequent in case vignettes without CVD compared to those with CVD (ORadj 13.8, 95%CI 12.6–15.1), with side effects compared to without ORadj 1.62 (95%CI 1.5–1.7) and with frailty (ORadj 4.1, 95%CI 3.8–4.4) compared to without. Shortened life expectancy increased advice to stop (ORadj 50.7, 95%CI 45.5–56.4) and was the strongest predictor for GP advice to stop, ranging across countries from 30% (95%CI 19–42) to 98% (95% CI 96–99). Conclusions: The absence of CVD, the presence of statin-related side effects, and frailty were all independently associated with GPs’ advice to stop statins in patients aged &gt; 80 years. Overall, and within all countries, cancer-related short life expectancy was the strongest independent predictor of GPs’ advice to stop statins. © 2019, The Author(s).},
  author       = {van der Ploeg, M. A. and Petrazzuoli, Ferdinando and Thulesius, Hans and Poortvliet, Rosalinde K.E. and , },
  issn         = {0884-8734},
  keyword      = {cardiovascular diseases,clinical decision-making,drug therapy,general practitioners,hydroxymethylglutaryl-CoA reductase inhibitors,palliative care},
  language     = {eng},
  publisher    = {Springer New York},
  series       = {Journal of General Internal Medicine},
  title        = {Patient Characteristics and General Practitioners’ Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries},
  url          = {http://dx.doi.org/10.1007/s11606-018-4795-x},
  year         = {2019},
}