Finite Element Model to Reproduce the Effect of Pre-Stress and Needle Insertion Velocity During Infusions into Brain Phantom Gel
(2021) In IRBM 42(3). p.180-188- Abstract
Convection-enhanced delivery (CED) is a technique to bypass the blood-brain barrier and deliver therapeutic agents into the brain. However, animal studies and preliminary clinical trials have reported reduced efficacy to transport drugs in specific regions, attributed mainly to backflow, in which an annular zone is formed outside the catheter and the fluid preferentially flows toward the surface of the brain rather than through the tissue toward the targeted area. In this study, a finite element model of backflow was updated by implementing the pre-stress generated during needle insertion, which allows considering the effect of needle insertion velocity during CED infusions in agarose gel. The nonlinear mechanical properties of the... (More)
Convection-enhanced delivery (CED) is a technique to bypass the blood-brain barrier and deliver therapeutic agents into the brain. However, animal studies and preliminary clinical trials have reported reduced efficacy to transport drugs in specific regions, attributed mainly to backflow, in which an annular zone is formed outside the catheter and the fluid preferentially flows toward the surface of the brain rather than through the tissue toward the targeted area. In this study, a finite element model of backflow was updated by implementing the pre-stress generated during needle insertion, which allows considering the effect of needle insertion velocity during CED infusions in agarose gel. The nonlinear mechanical properties of the agarose solutions were obtained by fitting experimental data from stress-relaxation tests. Additional experimental measurements of backflow lengths were used to adjust the pre-stress model. The developed model was able to reproduce changes of backflow length under different insertions velocities and flow rates. These findings reveal the relevance of considering the pre-stress in the tissue located around the needle surface during CED infusions into the brain.
(Less)
- author
- Orozco, G. A. LU ; Córdoba, G. ; Urrea, F. ; Casanova, F. ; Smith, J. H. and García, J. J.
- publishing date
- 2021-06
- type
- Contribution to journal
- publication status
- published
- keywords
- Agarose hydrogel, Backflow, Brain tumor, Convection-enhanced delivery, Finite element model, Pre-stress
- in
- IRBM
- volume
- 42
- issue
- 3
- pages
- 9 pages
- publisher
- Elsevier Masson SAS
- external identifiers
-
- scopus:85084399001
- ISSN
- 1959-0318
- DOI
- 10.1016/j.irbm.2020.04.005
- language
- English
- LU publication?
- no
- additional info
- Funding Information: This project has received funding from the Colciencias program 516-2012 “ Programa Nacional de Ciencia y Tecnología de la Salud ” No. 110656933826 . Thanks for the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie No. 713645 . Funding Information: This project has received funding from the Colciencias program 516-2012 “Programa Nacional de Ciencia y Tecnología de la Salud” No. 110656933826. Thanks for the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie No. 713645.The authors appreciate the support of the University of Eastern Finland, Lafayette College and Universidad del Valle to undertake this study. Publisher Copyright: © 2020 AGBM
- id
- 5e97c262-6ea4-4453-bbe2-f4280715bae2
- date added to LUP
- 2022-06-08 11:43:58
- date last changed
- 2022-06-23 10:50:05
@article{5e97c262-6ea4-4453-bbe2-f4280715bae2,
abstract = {{<p>Convection-enhanced delivery (CED) is a technique to bypass the blood-brain barrier and deliver therapeutic agents into the brain. However, animal studies and preliminary clinical trials have reported reduced efficacy to transport drugs in specific regions, attributed mainly to backflow, in which an annular zone is formed outside the catheter and the fluid preferentially flows toward the surface of the brain rather than through the tissue toward the targeted area. In this study, a finite element model of backflow was updated by implementing the pre-stress generated during needle insertion, which allows considering the effect of needle insertion velocity during CED infusions in agarose gel. The nonlinear mechanical properties of the agarose solutions were obtained by fitting experimental data from stress-relaxation tests. Additional experimental measurements of backflow lengths were used to adjust the pre-stress model. The developed model was able to reproduce changes of backflow length under different insertions velocities and flow rates. These findings reveal the relevance of considering the pre-stress in the tissue located around the needle surface during CED infusions into the brain.</p>}},
author = {{Orozco, G. A. and Córdoba, G. and Urrea, F. and Casanova, F. and Smith, J. H. and García, J. J.}},
issn = {{1959-0318}},
keywords = {{Agarose hydrogel; Backflow; Brain tumor; Convection-enhanced delivery; Finite element model; Pre-stress}},
language = {{eng}},
number = {{3}},
pages = {{180--188}},
publisher = {{Elsevier Masson SAS}},
series = {{IRBM}},
title = {{Finite Element Model to Reproduce the Effect of Pre-Stress and Needle Insertion Velocity During Infusions into Brain Phantom Gel}},
url = {{http://dx.doi.org/10.1016/j.irbm.2020.04.005}},
doi = {{10.1016/j.irbm.2020.04.005}},
volume = {{42}},
year = {{2021}},
}