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Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration

Chen, Peilin ; Wu, Zhigang ; Leung, Alex ; Chen, Xiaobo ; Landao-Bassonga, Euphemie ; Gao, Junjie ; Chen, Lianzhi ; Zheng, Monica ; Yao, Felix and Yang, Hong , et al. (2018) In Biomedical materials (Bristol, England) 13(6).
Abstract

Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa... (More)

Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with limited cellular toxicity. It also displayed effective anti-inflammatory effects by reducing the expression and release of inflammatory cytokines including IL-6 and TNF-alpha. Additionally, AgNP-coated collagen membranes were able to induce osteogenic differentiation of mesenchymal stem cells that guide bone regeneration. These findings demonstrate the potential application of AgNP-coated collagen membranes to prevent infection after bone graft introduction in alveolar ridge reconstruction.

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Contribution to journal
publication status
published
subject
in
Biomedical materials (Bristol, England)
volume
13
issue
6
article number
065014
publisher
IOP Publishing
external identifiers
  • scopus:85054399200
  • pmid:30213920
ISSN
1748-6041
DOI
10.1088/1748-605X/aae15b
language
English
LU publication?
yes
id
5ec0b3f2-a871-43dd-a65e-1b280d7803b1
date added to LUP
2019-06-11 14:01:00
date last changed
2019-11-20 05:46:53
@article{5ec0b3f2-a871-43dd-a65e-1b280d7803b1,
  abstract     = {<p>Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with limited cellular toxicity. It also displayed effective anti-inflammatory effects by reducing the expression and release of inflammatory cytokines including IL-6 and TNF-alpha. Additionally, AgNP-coated collagen membranes were able to induce osteogenic differentiation of mesenchymal stem cells that guide bone regeneration. These findings demonstrate the potential application of AgNP-coated collagen membranes to prevent infection after bone graft introduction in alveolar ridge reconstruction.</p>},
  author       = {Chen, Peilin and Wu, Zhigang and Leung, Alex and Chen, Xiaobo and Landao-Bassonga, Euphemie and Gao, Junjie and Chen, Lianzhi and Zheng, Monica and Yao, Felix and Yang, Hong and Lidgren, Lars and Allan, Brent and Liu, Yinong and Wang, Tao and Zheng, Minghao},
  issn         = {1748-6041},
  language     = {eng},
  month        = {10},
  number       = {6},
  publisher    = {IOP Publishing},
  series       = {Biomedical materials (Bristol, England)},
  title        = {Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration},
  url          = {http://dx.doi.org/10.1088/1748-605X/aae15b},
  doi          = {10.1088/1748-605X/aae15b},
  volume       = {13},
  year         = {2018},
}