Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration
(2018) In Biomedical materials 13(6).- Abstract
Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa... (More)
Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with limited cellular toxicity. It also displayed effective anti-inflammatory effects by reducing the expression and release of inflammatory cytokines including IL-6 and TNF-alpha. Additionally, AgNP-coated collagen membranes were able to induce osteogenic differentiation of mesenchymal stem cells that guide bone regeneration. These findings demonstrate the potential application of AgNP-coated collagen membranes to prevent infection after bone graft introduction in alveolar ridge reconstruction.
(Less)
- author
- organization
- publishing date
- 2018-10-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biomedical materials
- volume
- 13
- issue
- 6
- article number
- 065014
- publisher
- IOP Publishing
- external identifiers
-
- pmid:30213920
- scopus:85054399200
- ISSN
- 1748-6041
- DOI
- 10.1088/1748-605X/aae15b
- language
- English
- LU publication?
- yes
- id
- 5ec0b3f2-a871-43dd-a65e-1b280d7803b1
- date added to LUP
- 2019-06-11 14:01:00
- date last changed
- 2024-04-16 10:24:50
@article{5ec0b3f2-a871-43dd-a65e-1b280d7803b1,
abstract = {{<p>Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with limited cellular toxicity. It also displayed effective anti-inflammatory effects by reducing the expression and release of inflammatory cytokines including IL-6 and TNF-alpha. Additionally, AgNP-coated collagen membranes were able to induce osteogenic differentiation of mesenchymal stem cells that guide bone regeneration. These findings demonstrate the potential application of AgNP-coated collagen membranes to prevent infection after bone graft introduction in alveolar ridge reconstruction.</p>}},
author = {{Chen, Peilin and Wu, Zhigang and Leung, Alex and Chen, Xiaobo and Landao-Bassonga, Euphemie and Gao, Junjie and Chen, Lianzhi and Zheng, Monica and Yao, Felix and Yang, Hong and Lidgren, Lars and Allan, Brent and Liu, Yinong and Wang, Tao and Zheng, Minghao}},
issn = {{1748-6041}},
language = {{eng}},
month = {{10}},
number = {{6}},
publisher = {{IOP Publishing}},
series = {{Biomedical materials}},
title = {{Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration}},
url = {{http://dx.doi.org/10.1088/1748-605X/aae15b}},
doi = {{10.1088/1748-605X/aae15b}},
volume = {{13}},
year = {{2018}},
}