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Tumor biology, biomarkers, and liquid biopsy in pediatric renal tumors

Walz, Amy L. ; Maschietto, Mariana ; Crompton, Brian ; Evageliou, Nicholas ; Dix, David ; Tytgat, Godelieve ; Gessler, Manfred ; Gisselsson, David LU ; Daw, Najat C. and Wegert, Jenny (2023) In Pediatric Blood and Cancer 70(S2).
Abstract

The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new possibilities for diagnosis and treatment. In addition, there are growing data surrounding prognostic factors that can be used to stratify WT treatment to improve outcomes. Here, we review the molecular landscape of WT and other pediatric renal tumors as well as WT prognostic factors. We also review incorporation of circulating tumor DNA/liquid biopsies to leverage this molecular landscape, with potential use in the future for distinguishing renal tumors at the time of diagnosis and elucidating intratumor heterogeneity, which is not well... (More)

The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new possibilities for diagnosis and treatment. In addition, there are growing data surrounding prognostic factors that can be used to stratify WT treatment to improve outcomes. Here, we review the molecular landscape of WT and other pediatric renal tumors as well as WT prognostic factors. We also review incorporation of circulating tumor DNA/liquid biopsies to leverage this molecular landscape, with potential use in the future for distinguishing renal tumors at the time of diagnosis and elucidating intratumor heterogeneity, which is not well evaluated with standard biopsies. Incorporation of liquid biopsies will require longitudinal collection of multiple biospecimens. Further preclinical research, identification and validation of biomarkers, molecular studies, and data sharing among investigators are crucial to inform therapeutic strategies that improve patient outcomes.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarkers, liquid biopsy, pediatric renal tumors, tumor biology, Wilms tumor
in
Pediatric Blood and Cancer
volume
70
issue
S2
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:36592003
  • scopus:85145404339
ISSN
1545-5009
DOI
10.1002/pbc.30130
language
English
LU publication?
yes
id
5ef3785e-5fc9-40df-b6ef-e4eaba6b2016
date added to LUP
2023-02-13 14:09:15
date last changed
2024-06-13 23:39:38
@article{5ef3785e-5fc9-40df-b6ef-e4eaba6b2016,
  abstract     = {{<p>The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new possibilities for diagnosis and treatment. In addition, there are growing data surrounding prognostic factors that can be used to stratify WT treatment to improve outcomes. Here, we review the molecular landscape of WT and other pediatric renal tumors as well as WT prognostic factors. We also review incorporation of circulating tumor DNA/liquid biopsies to leverage this molecular landscape, with potential use in the future for distinguishing renal tumors at the time of diagnosis and elucidating intratumor heterogeneity, which is not well evaluated with standard biopsies. Incorporation of liquid biopsies will require longitudinal collection of multiple biospecimens. Further preclinical research, identification and validation of biomarkers, molecular studies, and data sharing among investigators are crucial to inform therapeutic strategies that improve patient outcomes.</p>}},
  author       = {{Walz, Amy L. and Maschietto, Mariana and Crompton, Brian and Evageliou, Nicholas and Dix, David and Tytgat, Godelieve and Gessler, Manfred and Gisselsson, David and Daw, Najat C. and Wegert, Jenny}},
  issn         = {{1545-5009}},
  keywords     = {{biomarkers; liquid biopsy; pediatric renal tumors; tumor biology; Wilms tumor}},
  language     = {{eng}},
  number       = {{S2}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Pediatric Blood and Cancer}},
  title        = {{Tumor biology, biomarkers, and liquid biopsy in pediatric renal tumors}},
  url          = {{http://dx.doi.org/10.1002/pbc.30130}},
  doi          = {{10.1002/pbc.30130}},
  volume       = {{70}},
  year         = {{2023}},
}