Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism
(2010) In Journal of Internal Medicine 268(4). p.320-328- Abstract
- Recent studies have revealed a close relationship between inflammatory and metabolic pathways, and inflammation is now recognized to have a major role in obesity and metabolic diseases such as insulin resistance and atherosclerosis. The human body is home to a large number of distinct microbial communities, with the densest population in the distal gut (the gut microbiota). Bacteria have long been known to activate inflammatory pathways, and recent data demonstrate that the gut microbiota may affect lipid metabolism and function as an environmental factor that influences the development of obesity and related diseases. Here, we review how the gut microbiota may affect metabolic diseases by activating the innate immune system.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4616744
- author
- Caesar, R. ; Fåk, Frida LU and Backhed, F.
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lipid Metabolism/*physiology, Intestinal Absorption, Innate, Immunity, Humans, Gastrointestinal Tract/immunology/*microbiology, Atherosclerosis/immunology/*microbiology, Biological Transport, Lipopolysaccharides/metabolism, Metagenome/*physiology, Obesity/immunology/*microbiology, Toll-Like Receptors/metabolism
- in
- Journal of Internal Medicine
- volume
- 268
- issue
- 4
- pages
- 320 - 328
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:77956310020
- ISSN
- 1365-2796
- DOI
- 10.1111/j.1365-2796.2010.02270.x
- language
- English
- LU publication?
- no
- additional info
- 4
- id
- 5ef86c04-484b-4829-b6cb-eb4eb629e79e (old id 4616744)
- date added to LUP
- 2016-04-04 09:26:04
- date last changed
- 2024-01-12 13:26:59
@article{5ef86c04-484b-4829-b6cb-eb4eb629e79e, abstract = {{Recent studies have revealed a close relationship between inflammatory and metabolic pathways, and inflammation is now recognized to have a major role in obesity and metabolic diseases such as insulin resistance and atherosclerosis. The human body is home to a large number of distinct microbial communities, with the densest population in the distal gut (the gut microbiota). Bacteria have long been known to activate inflammatory pathways, and recent data demonstrate that the gut microbiota may affect lipid metabolism and function as an environmental factor that influences the development of obesity and related diseases. Here, we review how the gut microbiota may affect metabolic diseases by activating the innate immune system.}}, author = {{Caesar, R. and Fåk, Frida and Backhed, F.}}, issn = {{1365-2796}}, keywords = {{Lipid Metabolism/*physiology; Intestinal Absorption; Innate; Immunity; Humans; Gastrointestinal Tract/immunology/*microbiology; Atherosclerosis/immunology/*microbiology; Biological Transport; Lipopolysaccharides/metabolism; Metagenome/*physiology; Obesity/immunology/*microbiology; Toll-Like Receptors/metabolism}}, language = {{eng}}, number = {{4}}, pages = {{320--328}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Internal Medicine}}, title = {{Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism}}, url = {{http://dx.doi.org/10.1111/j.1365-2796.2010.02270.x}}, doi = {{10.1111/j.1365-2796.2010.02270.x}}, volume = {{268}}, year = {{2010}}, }