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AS3MT polymorphisms, arsenic metabolites and pregnancy

Stajnko, A. LU ; Šlejkovec, Z. ; Mazej, D. ; Horvat, Milena and Falnoga, I. (2018) 7th International Congress and Exhibition Arsenic in the Environment, 2018 In Environmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018 p.326-327
Abstract

Arsenic methylating enzyme (AS3MT) genetic variations and their role in variability of As metabolism were evaluated in population of pregnant/non-pregnant women exposed to low levels of As. We have tested the associations between genotypes/haplotype of seven AS3MT SNPs and As metabolites in urine (methylation efficiency). Significant associations of individual SNPs and protective haplotype with arsenic metabolites have been confirmed among non-pregnant women. On the contrary, these associations have been almost absent among pregnant women – most possibly a counsequence of physiological changes in pregnancy, and/or impact of external DMA due to higher seafood intake. Both factors can influence As metabolism.

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author
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publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
host publication
Environmental Arsenic in a ChangingWorld : Proceedings of the 7th International Congress and Exhibition on Arsenic in the Environment (AS 2018), July 1-6, 2018, Beijing, P.R. China - Proceedings of the 7th International Congress and Exhibition on Arsenic in the Environment (AS 2018), July 1-6, 2018, Beijing, P.R. China
series title
Environmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018
editor
Zhu, Yong-Guan ; Zhu, Yong-Guan ; Guo, Huaming ; Guo, Huaming ; Bhattacharya, Prosun ; Bhattacharya, Prosun ; Bundschuh, Jochen ; Ahmad, Arslan ; Ahmad, Arslan ; Ahmad, Arslan ; Naidu, Ravi and Naidu, Ravi
edition
1
pages
2 pages
publisher
CRC Press/Balkema
conference name
7th International Congress and Exhibition Arsenic in the Environment, 2018
conference location
Beijing, China
conference dates
2018-07-01 - 2018-07-06
external identifiers
  • scopus:85079245147
ISBN
ISBN9781351046633
9781138486096
DOI
10.1201/9781351046633-129
language
English
LU publication?
no
additional info
Publisher Copyright: © 2018, CRC Press/Balkema. All rights reserved.
id
5f12dc44-28ef-4aad-81ce-5263a727acc2
date added to LUP
2025-02-21 21:45:07
date last changed
2025-02-24 08:32:54
@inproceedings{5f12dc44-28ef-4aad-81ce-5263a727acc2,
  abstract     = {{<p>Arsenic methylating enzyme (AS3MT) genetic variations and their role in variability of As metabolism were evaluated in population of pregnant/non-pregnant women exposed to low levels of As. We have tested the associations between genotypes/haplotype of seven AS3MT SNPs and As metabolites in urine (methylation efficiency). Significant associations of individual SNPs and protective haplotype with arsenic metabolites have been confirmed among non-pregnant women. On the contrary, these associations have been almost absent among pregnant women – most possibly a counsequence of physiological changes in pregnancy, and/or impact of external DMA due to higher seafood intake. Both factors can influence As metabolism.</p>}},
  author       = {{Stajnko, A. and Šlejkovec, Z. and Mazej, D. and Horvat, Milena and Falnoga, I.}},
  booktitle    = {{Environmental Arsenic in a ChangingWorld : Proceedings of the 7th International Congress and Exhibition on Arsenic in the Environment (AS 2018), July 1-6, 2018, Beijing, P.R. China}},
  editor       = {{Zhu, Yong-Guan and Zhu, Yong-Guan and Guo, Huaming and Guo, Huaming and Bhattacharya, Prosun and Bhattacharya, Prosun and Bundschuh, Jochen and Ahmad, Arslan and Ahmad, Arslan and Ahmad, Arslan and Naidu, Ravi and Naidu, Ravi}},
  isbn         = {{ISBN9781351046633}},
  language     = {{eng}},
  pages        = {{326--327}},
  publisher    = {{CRC Press/Balkema}},
  series       = {{Environmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018}},
  title        = {{AS3MT polymorphisms, arsenic metabolites and pregnancy}},
  url          = {{http://dx.doi.org/10.1201/9781351046633-129}},
  doi          = {{10.1201/9781351046633-129}},
  year         = {{2018}},
}