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New insight into the causes, consequences, and correction of hematopoietic stem cell aging

Mansell, Els LU ; Lin, Dawn S. ; Loughran, Stephen J. ; Milsom, Michael D. and Trowbridge, Jennifer J. (2023) In Experimental Hematology 125-126. p.1-5
Abstract

Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways, and downregulation of DNA repair pathways. Cellular aging of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes a predisposition to anemia, adaptive immune compromise, myelodys, plasia, and malignancy. Most hematologic diseases are strongly associated with age. But what is the biological foundation for decreased fitness with age? And are there therapeutic windows to resolve age-related hematopoietic decline? These questions were the focus of the International Society for... (More)

Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways, and downregulation of DNA repair pathways. Cellular aging of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes a predisposition to anemia, adaptive immune compromise, myelodys, plasia, and malignancy. Most hematologic diseases are strongly associated with age. But what is the biological foundation for decreased fitness with age? And are there therapeutic windows to resolve age-related hematopoietic decline? These questions were the focus of the International Society for Experimental Hematology (ISEH) New Investigator Committee Fall 2022 Webinar. This review touches on the latest insights from two leading laboratories into inflammatory- and niche-driven stem cell aging and includes speculation on strategies to prevent or correct age-related decline in HSC function.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Hematology
volume
125-126
pages
1 - 5
publisher
Elsevier
external identifiers
  • pmid:37433369
  • scopus:85165492180
ISSN
0301-472X
DOI
10.1016/j.exphem.2023.07.002
language
English
LU publication?
yes
id
5f28704c-6f93-410e-a807-53f6322c83f8
date added to LUP
2023-09-20 11:17:37
date last changed
2025-01-11 04:21:05
@article{5f28704c-6f93-410e-a807-53f6322c83f8,
  abstract     = {{<p>Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways, and downregulation of DNA repair pathways. Cellular aging of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes a predisposition to anemia, adaptive immune compromise, myelodys, plasia, and malignancy. Most hematologic diseases are strongly associated with age. But what is the biological foundation for decreased fitness with age? And are there therapeutic windows to resolve age-related hematopoietic decline? These questions were the focus of the International Society for Experimental Hematology (ISEH) New Investigator Committee Fall 2022 Webinar. This review touches on the latest insights from two leading laboratories into inflammatory- and niche-driven stem cell aging and includes speculation on strategies to prevent or correct age-related decline in HSC function.</p>}},
  author       = {{Mansell, Els and Lin, Dawn S. and Loughran, Stephen J. and Milsom, Michael D. and Trowbridge, Jennifer J.}},
  issn         = {{0301-472X}},
  language     = {{eng}},
  pages        = {{1--5}},
  publisher    = {{Elsevier}},
  series       = {{Experimental Hematology}},
  title        = {{New insight into the causes, consequences, and correction of hematopoietic stem cell aging}},
  url          = {{http://dx.doi.org/10.1016/j.exphem.2023.07.002}},
  doi          = {{10.1016/j.exphem.2023.07.002}},
  volume       = {{125-126}},
  year         = {{2023}},
}