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Rodent models of treatment-induced motor complications in Parkinson's disease

Cenci Nilsson, Angela LU and Ohlin, Elisabet LU (2009) In Parkinsonism and Related Disorders 15 Suppl 4. p.7-13
Abstract

Treatment-induced motor complications represent a major clinical problem in Parkinson's disease (PD). Pharmacological dopamine (DA) replacement with l-dopa causes motor fluctuations and abnormal involuntary movements (dyskinesia) in the vast majority of the patients. Intrastriatal grafts of embryonic dopaminergic neurons can cause dyskinesia too, as shown by clinical trials of neural transplantation in PD. Animals models of these complications can be produced in rats and mice in which the nigrostriatal DA pathway has been severely damaged. Rodent models allow investigators to explore mechanistic hypotheses at the cellular and molecular level. Moreover, the rat model of L-dopa-induced abnormal involuntary movements shows both face... (More)

Treatment-induced motor complications represent a major clinical problem in Parkinson's disease (PD). Pharmacological dopamine (DA) replacement with l-dopa causes motor fluctuations and abnormal involuntary movements (dyskinesia) in the vast majority of the patients. Intrastriatal grafts of embryonic dopaminergic neurons can cause dyskinesia too, as shown by clinical trials of neural transplantation in PD. Animals models of these complications can be produced in rats and mice in which the nigrostriatal DA pathway has been severely damaged. Rodent models allow investigators to explore mechanistic hypotheses at the cellular and molecular level. Moreover, the rat model of L-dopa-induced abnormal involuntary movements shows both face validity and predictive validity relative to the corresponding disorder in primates, and provides a cost effective tool to evaluate novel antidyskinetic interventions. This article reviews the strategies that have been used to reproduce different motor complications of PD treatment in rodents, and comments on their range of applicability.

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publication status
published
subject
keywords
Animals, Brain Tissue Transplantation, Disease Models, Animal, Dyskinesia, Drug-Induced, Humans, Levodopa, Mice, Motor Skills Disorders, Parkinson Disease, Rats, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Parkinsonism and Related Disorders
volume
15 Suppl 4
pages
7 - 13
publisher
Elsevier
external identifiers
  • scopus:72649106419
ISSN
1873-5126
DOI
10.1016/S1353-8020(09)70828-4
language
English
LU publication?
yes
id
5f53eb8a-071b-45eb-aada-5e3045e47366
date added to LUP
2017-04-03 12:28:15
date last changed
2017-10-22 05:28:54
@article{5f53eb8a-071b-45eb-aada-5e3045e47366,
  abstract     = {<p>Treatment-induced motor complications represent a major clinical problem in Parkinson's disease (PD). Pharmacological dopamine (DA) replacement with l-dopa causes motor fluctuations and abnormal involuntary movements (dyskinesia) in the vast majority of the patients. Intrastriatal grafts of embryonic dopaminergic neurons can cause dyskinesia too, as shown by clinical trials of neural transplantation in PD. Animals models of these complications can be produced in rats and mice in which the nigrostriatal DA pathway has been severely damaged. Rodent models allow investigators to explore mechanistic hypotheses at the cellular and molecular level. Moreover, the rat model of L-dopa-induced abnormal involuntary movements shows both face validity and predictive validity relative to the corresponding disorder in primates, and provides a cost effective tool to evaluate novel antidyskinetic interventions. This article reviews the strategies that have been used to reproduce different motor complications of PD treatment in rodents, and comments on their range of applicability.</p>},
  author       = {Cenci Nilsson, Angela and Ohlin, Elisabet},
  issn         = {1873-5126},
  keyword      = {Animals,Brain Tissue Transplantation,Disease Models, Animal,Dyskinesia, Drug-Induced,Humans,Levodopa,Mice,Motor Skills Disorders,Parkinson Disease,Rats,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  pages        = {7--13},
  publisher    = {Elsevier},
  series       = {Parkinsonism and Related Disorders},
  title        = {Rodent models of treatment-induced motor complications in Parkinson's disease},
  url          = {http://dx.doi.org/10.1016/S1353-8020(09)70828-4},
  volume       = {15 Suppl 4},
  year         = {2009},
}