Mutual information in random Boolean models of regulatory networks
(2008) In Physical Review E (Statistical, Nonlinear, and Soft Matter Physics) 77(1).- Abstract
- The amount of mutual information contained in the time series of two elements gives a measure of how well their activities are coordinated. In a large, complex network of interacting elements, such as a genetic regulatory network within a cell, the average of the mutual information over all pairs, ⟨I⟩, is a global measure of how well the system can coordinate its internal dynamics. We study this average pairwise mutual information in random Boolean networks (RBNs) as a function of the distribution of Boolean rules implemented at each element, assuming that the links in the network are randomly placed. Efficient numerical methods for calculating ⟨I⟩ show that as the number of network nodes, N, approaches infinity, the quantity N⟨I⟩ exhibits... (More)
- The amount of mutual information contained in the time series of two elements gives a measure of how well their activities are coordinated. In a large, complex network of interacting elements, such as a genetic regulatory network within a cell, the average of the mutual information over all pairs, ⟨I⟩, is a global measure of how well the system can coordinate its internal dynamics. We study this average pairwise mutual information in random Boolean networks (RBNs) as a function of the distribution of Boolean rules implemented at each element, assuming that the links in the network are randomly placed. Efficient numerical methods for calculating ⟨I⟩ show that as the number of network nodes, N, approaches infinity, the quantity N⟨I⟩ exhibits a discontinuity at parameter values corresponding to critical RBNs. For finite systems it peaks near the critical value, but slightly in the disordered regime for typical parameter variations. The source of high values of N⟨I⟩ is the indirect correlations between pairs of elements from different long chains with a common starting point. The contribution from pairs that are directly linked approaches zero for critical networks and peaks deep in the disordered regime. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1260884
- author
- Ribeiro, Andre S. ; Kauffman, Stuart A. ; Lloyd-Price, Jason ; Samuelsson, Björn LU and Socolar, Joshua E. S.
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)
- volume
- 77
- issue
- 1
- article number
- 011901
- publisher
- American Physical Society
- external identifiers
-
- scopus:40749150320
- pmid:18351870
- ISSN
- 1539-3755
- DOI
- 10.1103/PhysRevE.77.011901
- language
- English
- LU publication?
- no
- id
- 5f6b2cb2-6424-4e25-886b-4aa3c34af5b1 (old id 1260884)
- alternative location
- http://link.aps.org/abstract/PRE/v77/e011901
- date added to LUP
- 2016-04-01 12:11:58
- date last changed
- 2022-04-05 18:55:25
@article{5f6b2cb2-6424-4e25-886b-4aa3c34af5b1,
abstract = {{The amount of mutual information contained in the time series of two elements gives a measure of how well their activities are coordinated. In a large, complex network of interacting elements, such as a genetic regulatory network within a cell, the average of the mutual information over all pairs, ⟨I⟩, is a global measure of how well the system can coordinate its internal dynamics. We study this average pairwise mutual information in random Boolean networks (RBNs) as a function of the distribution of Boolean rules implemented at each element, assuming that the links in the network are randomly placed. Efficient numerical methods for calculating ⟨I⟩ show that as the number of network nodes, N, approaches infinity, the quantity N⟨I⟩ exhibits a discontinuity at parameter values corresponding to critical RBNs. For finite systems it peaks near the critical value, but slightly in the disordered regime for typical parameter variations. The source of high values of N⟨I⟩ is the indirect correlations between pairs of elements from different long chains with a common starting point. The contribution from pairs that are directly linked approaches zero for critical networks and peaks deep in the disordered regime.}},
author = {{Ribeiro, Andre S. and Kauffman, Stuart A. and Lloyd-Price, Jason and Samuelsson, Björn and Socolar, Joshua E. S.}},
issn = {{1539-3755}},
language = {{eng}},
number = {{1}},
publisher = {{American Physical Society}},
series = {{Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)}},
title = {{Mutual information in random Boolean models of regulatory networks}},
url = {{http://dx.doi.org/10.1103/PhysRevE.77.011901}},
doi = {{10.1103/PhysRevE.77.011901}},
volume = {{77}},
year = {{2008}},
}