Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin.
(2014) In Genes, Chromosomes and Cancer 53(5). p.381-391- Abstract
- Clear cell sarcoma of the kidney (CCSK) is a tumor affecting children with a median age of 3 years at diagnosis. The cell of origin of CCSK is unknown and data on the molecular changes giving rise to CCSK is scarce. This has hindered the identification of positive diagnostic markers and development of molecularly targeted treatment protocols for CCSK. We have characterized a panel of CCSK to gain information regarding its molecular profile and possible origin. High-resolution genomic analysis with single nucleotide polymorphism array of 37 tumors did not reveal any clues to the mechanisms behind tumor development as remarkably few genetic imbalances were found. Gene expression analysis revealed a highly characteristic gene signature,... (More)
- Clear cell sarcoma of the kidney (CCSK) is a tumor affecting children with a median age of 3 years at diagnosis. The cell of origin of CCSK is unknown and data on the molecular changes giving rise to CCSK is scarce. This has hindered the identification of positive diagnostic markers and development of molecularly targeted treatment protocols for CCSK. We have characterized a panel of CCSK to gain information regarding its molecular profile and possible origin. High-resolution genomic analysis with single nucleotide polymorphism array of 37 tumors did not reveal any clues to the mechanisms behind tumor development as remarkably few genetic imbalances were found. Gene expression analysis revealed a highly characteristic gene signature, enriched for pathways involved in embryonic development, including kidney formation. The presence of markers for two different developmental lineages in the embryonic kidney was therefore investigated in the tumor cells. FOXD1 which identifies cells giving rise to stromal elements, and CITED1, a marker for cells primed for nephrogenic epithelial differentiation, were both highly expressed in CCSK. In addition, the early embryonic marker OSR1 was expressed at higher levels in CCSK than in Wilms tumor, normal fetal kidney or adult kidney. As this marker discriminates the intermediate mesoderm from other mesodermal structures, our study could suggest that CCSK arises from a mesodermal cell type that retains the capacity to initiate differentiation towards both nephrons and stroma, but remains locked in a primitive state. © 2014 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4335870
- author
- Karlsson, Jenny LU ; Holmquist Mengelbier, Linda LU ; Ciornei, Cristina LU ; Naranjo, Arlene ; O'Sullivan, Maureen J and Gisselsson Nord, David LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes, Chromosomes and Cancer
- volume
- 53
- issue
- 5
- pages
- 381 - 391
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:24488803
- wos:000332695000002
- scopus:84895926355
- pmid:24488803
- ISSN
- 1045-2257
- DOI
- 10.1002/gcc.22149
- language
- English
- LU publication?
- yes
- id
- 5f8cc9c9-1cab-48ae-bb44-18bd6a7524d2 (old id 4335870)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24488803?dopt=Abstract
- date added to LUP
- 2016-04-01 10:27:16
- date last changed
- 2022-04-27 22:14:06
@article{5f8cc9c9-1cab-48ae-bb44-18bd6a7524d2,
abstract = {{Clear cell sarcoma of the kidney (CCSK) is a tumor affecting children with a median age of 3 years at diagnosis. The cell of origin of CCSK is unknown and data on the molecular changes giving rise to CCSK is scarce. This has hindered the identification of positive diagnostic markers and development of molecularly targeted treatment protocols for CCSK. We have characterized a panel of CCSK to gain information regarding its molecular profile and possible origin. High-resolution genomic analysis with single nucleotide polymorphism array of 37 tumors did not reveal any clues to the mechanisms behind tumor development as remarkably few genetic imbalances were found. Gene expression analysis revealed a highly characteristic gene signature, enriched for pathways involved in embryonic development, including kidney formation. The presence of markers for two different developmental lineages in the embryonic kidney was therefore investigated in the tumor cells. FOXD1 which identifies cells giving rise to stromal elements, and CITED1, a marker for cells primed for nephrogenic epithelial differentiation, were both highly expressed in CCSK. In addition, the early embryonic marker OSR1 was expressed at higher levels in CCSK than in Wilms tumor, normal fetal kidney or adult kidney. As this marker discriminates the intermediate mesoderm from other mesodermal structures, our study could suggest that CCSK arises from a mesodermal cell type that retains the capacity to initiate differentiation towards both nephrons and stroma, but remains locked in a primitive state. © 2014 Wiley Periodicals, Inc.}},
author = {{Karlsson, Jenny and Holmquist Mengelbier, Linda and Ciornei, Cristina and Naranjo, Arlene and O'Sullivan, Maureen J and Gisselsson Nord, David}},
issn = {{1045-2257}},
language = {{eng}},
number = {{5}},
pages = {{381--391}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Genes, Chromosomes and Cancer}},
title = {{Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin.}},
url = {{http://dx.doi.org/10.1002/gcc.22149}},
doi = {{10.1002/gcc.22149}},
volume = {{53}},
year = {{2014}},
}