The neurochemical profile quantified by in vivo 1H NMR spectroscopy
Duarte, João M N LU
; Lei, Hongxia
; Mlynárik, Vladimír
and Gruetter, Rolf
(2012)
In NeuroImage
61(2).
p.342-362
- Abstract
Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of (1)H NMR spectroscopy in basic and translational neuroscience research is discussed here.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5fee260f-abf0-4947-b551-e5a1ad2c82ac
- author
- Duarte, João M N
LU
; Lei, Hongxia
; Mlynárik, Vladimír
and Gruetter, Rolf
- publishing date
- 2012-06
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Blood-Brain Barrier, Brain, Brain Chemistry, Brain Neoplasms, Cell Proliferation, Electromagnetic Fields, Humans, Magnetic Resonance Spectroscopy, Membrane Lipids, Nervous System Diseases, Neurotransmitter Agents, Species Specificity, Translational Medical Research, Journal Article, Research Support, Non-U.S. Gov't, Review
- in
- NeuroImage
- volume
- 61
- issue
- 2
- pages
- 21 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84860713083
- pmid:22227137
- ISSN
- 1095-9572
- DOI
- 10.1016/j.neuroimage.2011.12.038
- language
- English
- LU publication?
- no
- id
- 5fee260f-abf0-4947-b551-e5a1ad2c82ac
- date added to LUP
- 2017-10-19 15:13:44
- date last changed
- 2025-04-29 07:11:52
@article{5fee260f-abf0-4947-b551-e5a1ad2c82ac,
abstract = {{<p>Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of (1)H NMR spectroscopy in basic and translational neuroscience research is discussed here.</p>}},
author = {{Duarte, João M N and Lei, Hongxia and Mlynárik, Vladimír and Gruetter, Rolf}},
issn = {{1095-9572}},
keywords = {{Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Neoplasms; Cell Proliferation; Electromagnetic Fields; Humans; Magnetic Resonance Spectroscopy; Membrane Lipids; Nervous System Diseases; Neurotransmitter Agents; Species Specificity; Translational Medical Research; Journal Article; Research Support, Non-U.S. Gov't; Review}},
language = {{eng}},
number = {{2}},
pages = {{342--362}},
publisher = {{Elsevier}},
series = {{NeuroImage}},
title = {{The neurochemical profile quantified by in vivo 1H NMR spectroscopy}},
url = {{http://dx.doi.org/10.1016/j.neuroimage.2011.12.038}},
doi = {{10.1016/j.neuroimage.2011.12.038}},
volume = {{61}},
year = {{2012}},
}