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The neurochemical profile quantified by in vivo 1H NMR spectroscopy

Duarte, João M N LU ; Lei, Hongxia; Mlynárik, Vladimír and Gruetter, Rolf (2012) In NeuroImage 61(2). p.342-362
Abstract

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of (1)H NMR spectroscopy in basic and translational neuroscience research is discussed here.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Blood-Brain Barrier, Brain, Brain Chemistry, Brain Neoplasms, Cell Proliferation, Electromagnetic Fields, Humans, Magnetic Resonance Spectroscopy, Membrane Lipids, Nervous System Diseases, Neurotransmitter Agents, Species Specificity, Translational Medical Research, Journal Article, Research Support, Non-U.S. Gov't, Review
in
NeuroImage
volume
61
issue
2
pages
21 pages
publisher
Elsevier
external identifiers
  • scopus:84860713083
ISSN
1095-9572
DOI
10.1016/j.neuroimage.2011.12.038
language
English
LU publication?
no
id
5fee260f-abf0-4947-b551-e5a1ad2c82ac
date added to LUP
2017-10-19 15:13:44
date last changed
2017-10-30 12:27:05
@article{5fee260f-abf0-4947-b551-e5a1ad2c82ac,
  abstract     = {<p>Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of (1)H NMR spectroscopy in basic and translational neuroscience research is discussed here.</p>},
  author       = {Duarte, João M N and Lei, Hongxia and Mlynárik, Vladimír and Gruetter, Rolf},
  issn         = {1095-9572},
  keyword      = {Animals,Blood-Brain Barrier,Brain,Brain Chemistry,Brain Neoplasms,Cell Proliferation,Electromagnetic Fields,Humans,Magnetic Resonance Spectroscopy,Membrane Lipids,Nervous System Diseases,Neurotransmitter Agents,Species Specificity,Translational Medical Research,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {2},
  pages        = {342--362},
  publisher    = {Elsevier},
  series       = {NeuroImage},
  title        = {The neurochemical profile quantified by in vivo 1H NMR spectroscopy},
  url          = {http://dx.doi.org/10.1016/j.neuroimage.2011.12.038},
  volume       = {61},
  year         = {2012},
}