Upper Gastrointestinal Bleeding : A Retrospective, Single-Center Experience on the Role of Endoscopy and Outcomes
(2025) In Journal of clinical medicine research 17(1). p.22-34- Abstract
BACKGROUND: Upper gastrointestinal bleeding (UGIB) is a common and potentially fatal medical emergency. This study aimed to investigate the frequency, causes, outcomes, and efficacy of endoscopy in the treatment of UGIB at King Fahad Central Hospital in Jazan, Saudi Arabia.
METHODS: Between January 2017 and December 2023, a retrospective study was performed including all hospitalized patients with UGIB. This research investigated sociodemographic characteristics, clinical history, endoscopic findings, treatment options, and results using statistical analysis, which included both descriptive and inferential approaches.
RESULTS: The study included 483 patients (of which 74.1% men), with a mean age of 53.9 ± 19.5 years.... (More)
BACKGROUND: Upper gastrointestinal bleeding (UGIB) is a common and potentially fatal medical emergency. This study aimed to investigate the frequency, causes, outcomes, and efficacy of endoscopy in the treatment of UGIB at King Fahad Central Hospital in Jazan, Saudi Arabia.
METHODS: Between January 2017 and December 2023, a retrospective study was performed including all hospitalized patients with UGIB. This research investigated sociodemographic characteristics, clinical history, endoscopic findings, treatment options, and results using statistical analysis, which included both descriptive and inferential approaches.
RESULTS: The study included 483 patients (of which 74.1% men), with a mean age of 53.9 ± 19.5 years. Hematemesis was observed in 67.5% of the patients, whereas melena occurred in 49.7% of the cases. Two-hundred sixty-two (54.2%) patients underwent endoscopy within the first 24 h from presentation. The most frequent endoscopic findings were esophageal varices (52.2%) and duodenal ulcers (21.7%). Bandings accounted for 48.0% of all endoscopic procedures, whereas 36.9% of the patients received epinephrine injections along with endoclips. Medical therapy mostly consisted of a mix of proton pump inhibitors (PPIs) and octreotide. A significant minority (43.5%) of the patients stayed in the hospital for 1 - 3 days, while 59.6% did not need blood transfusions. During the first 3 days, 7% of patients experienced rebleeding, with a 6% mortality rate. Using multivariate regression analysis, rebleeding was strongly associated with initial presentation with shock (P < 0.001), renal disease (P = 0.01), and increased transfusion requirement (P = 0.001). Mortality was strongly associated with steroid usage (P = 0.007), increasing transfusion requirements (P < 0.0001), and rebleeding (P = 0.002).
CONCLUSIONS: Timely endoscopy and proper treatment dramatically improved UGIB results. Identifying those who are at high risk and acting swiftly is a critical step in reducing the likelihood of recurrent bleeding and fatality.
(Less)
- author
- Someili, Ali M
; Mobarki, Sarah Jaber
; Moafa, Razan Hamoud
; Alsury, Leena Nageeb
; Shadad, Roaa Hassan
; Fathi, Shroog Mohammed
; Hamrani, Amnah Hussain
; Darisi, Afnan Mohammed
; Mohamed, Amal H
; Alqassmi, Sameer
; Mohrag, Mostafa
and Abdulrasak, Mohammed
LU
(Less) - organization
- publishing date
- 2025-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of clinical medicine research
- volume
- 17
- issue
- 1
- pages
- 22 - 34
- publisher
- Elmer Press
- external identifiers
-
- scopus:85216975101
- pmid:39866814
- ISSN
- 1918-3003
- DOI
- 10.14740/jocmr6134
- language
- English
- LU publication?
- yes
- additional info
- Copyright 2025, Someili et al.
- id
- 5ffb95b3-9bd9-45ca-822e-617ff37ce6d0
- date added to LUP
- 2025-01-28 18:15:30
- date last changed
- 2025-07-03 16:09:50
@article{5ffb95b3-9bd9-45ca-822e-617ff37ce6d0,
abstract = {{<p>BACKGROUND: Upper gastrointestinal bleeding (UGIB) is a common and potentially fatal medical emergency. This study aimed to investigate the frequency, causes, outcomes, and efficacy of endoscopy in the treatment of UGIB at King Fahad Central Hospital in Jazan, Saudi Arabia.</p><p>METHODS: Between January 2017 and December 2023, a retrospective study was performed including all hospitalized patients with UGIB. This research investigated sociodemographic characteristics, clinical history, endoscopic findings, treatment options, and results using statistical analysis, which included both descriptive and inferential approaches.</p><p>RESULTS: The study included 483 patients (of which 74.1% men), with a mean age of 53.9 ± 19.5 years. Hematemesis was observed in 67.5% of the patients, whereas melena occurred in 49.7% of the cases. Two-hundred sixty-two (54.2%) patients underwent endoscopy within the first 24 h from presentation. The most frequent endoscopic findings were esophageal varices (52.2%) and duodenal ulcers (21.7%). Bandings accounted for 48.0% of all endoscopic procedures, whereas 36.9% of the patients received epinephrine injections along with endoclips. Medical therapy mostly consisted of a mix of proton pump inhibitors (PPIs) and octreotide. A significant minority (43.5%) of the patients stayed in the hospital for 1 - 3 days, while 59.6% did not need blood transfusions. During the first 3 days, 7% of patients experienced rebleeding, with a 6% mortality rate. Using multivariate regression analysis, rebleeding was strongly associated with initial presentation with shock (P < 0.001), renal disease (P = 0.01), and increased transfusion requirement (P = 0.001). Mortality was strongly associated with steroid usage (P = 0.007), increasing transfusion requirements (P < 0.0001), and rebleeding (P = 0.002).</p><p>CONCLUSIONS: Timely endoscopy and proper treatment dramatically improved UGIB results. Identifying those who are at high risk and acting swiftly is a critical step in reducing the likelihood of recurrent bleeding and fatality.</p>}},
author = {{Someili, Ali M and Mobarki, Sarah Jaber and Moafa, Razan Hamoud and Alsury, Leena Nageeb and Shadad, Roaa Hassan and Fathi, Shroog Mohammed and Hamrani, Amnah Hussain and Darisi, Afnan Mohammed and Mohamed, Amal H and Alqassmi, Sameer and Mohrag, Mostafa and Abdulrasak, Mohammed}},
issn = {{1918-3003}},
language = {{eng}},
number = {{1}},
pages = {{22--34}},
publisher = {{Elmer Press}},
series = {{Journal of clinical medicine research}},
title = {{Upper Gastrointestinal Bleeding : A Retrospective, Single-Center Experience on the Role of Endoscopy and Outcomes}},
url = {{http://dx.doi.org/10.14740/jocmr6134}},
doi = {{10.14740/jocmr6134}},
volume = {{17}},
year = {{2025}},
}