C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
(2021) In Frontiers in Immunology 11.- Abstract
Objectives: Patients with systemic lupus erythematosus (SLE) often display modest elevations of C-reactive protein (CRP) despite raised disease activity and increased interleukin (IL-) 6. We asked to what extent IL-6 levels, the CRP polymorphism rs1205, and the type I interferon (IFN) gene signature affects the basal CRP levels in patients with SLE during a quiescent phase of the disease. Methods: CRP and IL-6 were analyzed in plasma from 57 patients meeting established classification criteria for SLE. The CRP polymorphism rs1205 was assessed and gene expression analyzed including four type I IFN-regulated genes (IGS). Results: CRP was increased in patients with detectable IL-6 levels (p=0.001) and decreased among IGS-positive subjects... (More)
Objectives: Patients with systemic lupus erythematosus (SLE) often display modest elevations of C-reactive protein (CRP) despite raised disease activity and increased interleukin (IL-) 6. We asked to what extent IL-6 levels, the CRP polymorphism rs1205, and the type I interferon (IFN) gene signature affects the basal CRP levels in patients with SLE during a quiescent phase of the disease. Methods: CRP and IL-6 were analyzed in plasma from 57 patients meeting established classification criteria for SLE. The CRP polymorphism rs1205 was assessed and gene expression analyzed including four type I IFN-regulated genes (IGS). Results: CRP was increased in patients with detectable IL-6 levels (p=0.001) and decreased among IGS-positive subjects (p=0.033). A multiple linear regression model revealed IL-6 to have a positive association with CRP levels, whereas both IGS-positivity and CRP genotype (rs1205) AA/GA were negatively associated with CRP-levels. Conclusion: Our data offer an explanation to the modest CRP levels seen in viral infections and IFN-α driven autoimmunity and corroborate prior observations showing an IFN-α dependent downregulation of CRP. The latter observation, together with the fact that the CRP-lowering polymorphism rs1205 is overrepresented in human SLE, could explain low basal CRP and inadequate CRP-responses among patients with active SLE.
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- author
- Enocsson, Helena ; Gullstrand, Birgitta LU ; Eloranta, Maija Leena ; Wetterö, Jonas ; Leonard, Dag ; Rönnblom, Lars ; Bengtsson, Anders A. LU and Sjöwall, Christopher
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biomarker, C-reactive protein, gene variants, inflammation, interferon, pentraxins, systemic lupus erythematosus, type I interferons
- in
- Frontiers in Immunology
- volume
- 11
- article number
- 622326
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:33584722
- scopus:85100965655
- ISSN
- 1664-3224
- DOI
- 10.3389/fimmu.2020.622326
- language
- English
- LU publication?
- yes
- id
- 6004cd35-dbad-460d-8671-7a15ba18b814
- date added to LUP
- 2021-03-02 09:32:07
- date last changed
- 2025-02-07 08:26:16
@article{6004cd35-dbad-460d-8671-7a15ba18b814, abstract = {{<p>Objectives: Patients with systemic lupus erythematosus (SLE) often display modest elevations of C-reactive protein (CRP) despite raised disease activity and increased interleukin (IL-) 6. We asked to what extent IL-6 levels, the CRP polymorphism rs1205, and the type I interferon (IFN) gene signature affects the basal CRP levels in patients with SLE during a quiescent phase of the disease. Methods: CRP and IL-6 were analyzed in plasma from 57 patients meeting established classification criteria for SLE. The CRP polymorphism rs1205 was assessed and gene expression analyzed including four type I IFN-regulated genes (IGS). Results: CRP was increased in patients with detectable IL-6 levels (p=0.001) and decreased among IGS-positive subjects (p=0.033). A multiple linear regression model revealed IL-6 to have a positive association with CRP levels, whereas both IGS-positivity and CRP genotype (rs1205) AA/GA were negatively associated with CRP-levels. Conclusion: Our data offer an explanation to the modest CRP levels seen in viral infections and IFN-α driven autoimmunity and corroborate prior observations showing an IFN-α dependent downregulation of CRP. The latter observation, together with the fact that the CRP-lowering polymorphism rs1205 is overrepresented in human SLE, could explain low basal CRP and inadequate CRP-responses among patients with active SLE.</p>}}, author = {{Enocsson, Helena and Gullstrand, Birgitta and Eloranta, Maija Leena and Wetterö, Jonas and Leonard, Dag and Rönnblom, Lars and Bengtsson, Anders A. and Sjöwall, Christopher}}, issn = {{1664-3224}}, keywords = {{biomarker; C-reactive protein; gene variants; inflammation; interferon; pentraxins; systemic lupus erythematosus; type I interferons}}, language = {{eng}}, publisher = {{Frontiers Media S. A.}}, series = {{Frontiers in Immunology}}, title = {{C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205}}, url = {{http://dx.doi.org/10.3389/fimmu.2020.622326}}, doi = {{10.3389/fimmu.2020.622326}}, volume = {{11}}, year = {{2021}}, }