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Structure-activity relationships for analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth, Agrotis segetum : Synthesis and conformational analysis

Bengtsson, Marie (1988)
Abstract
Structure-activity relationships for 28 analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth Agrotis segetum, have been studied.Synthesis and conformational analysis of chain-elongated, chain-shortened, alkyne, alkenyne, diene and cyclic analogues, and configurational isomers are presented.A conformational-energy model for the interaction of a pheromone component with its receptor cell has been developed and tested.The model is shown to correlate measured electrophysiological single-cell activities with conformational energies calculated by the molecular mechanics (MM2/MMP2) method.A biologically active conformation of the natural pheromone component, (Z)-5-decenyl acetate, is suggested.
Please use this url to cite or link to this publication:
author
supervisor
publishing date
type
Thesis
publication status
published
subject
keywords
Structure-activity relationships, Conformational analysis, Molecular mechanics, Agrotis segetum, Sex pheromone, Receptor interaction, Analogues of (Z)-5-decenyl acetate
pages
139 pages
publisher
Lund University
ISBN
9907128066
language
English
LU publication?
no
id
6015a2cc-4ffe-47eb-942e-b05af3eb1c89
date added to LUP
2021-05-04 11:09:12
date last changed
2021-05-05 18:56:36
@phdthesis{6015a2cc-4ffe-47eb-942e-b05af3eb1c89,
  abstract     = {{Structure-activity relationships for 28 analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth <i>Agrotis segetum</i>, have been studied.Synthesis and conformational analysis of chain-elongated, chain-shortened, alkyne, alkenyne, diene and cyclic analogues, and configurational isomers are presented.A conformational-energy model for the interaction of a pheromone component with its receptor cell has been developed and tested.The model is shown to correlate measured electrophysiological single-cell activities with conformational energies calculated by the molecular mechanics (MM2/MMP2) method.A biologically active conformation of the natural pheromone component, (Z)-5-decenyl acetate, is suggested.<br/>}},
  author       = {{Bengtsson, Marie}},
  isbn         = {{9907128066}},
  keywords     = {{Structure-activity relationships; Conformational analysis; Molecular mechanics; Agrotis segetum; Sex pheromone; Receptor interaction; Analogues of (Z)-5-decenyl acetate}},
  language     = {{eng}},
  publisher    = {{Lund University}},
  title        = {{Structure-activity relationships for analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth, <i>Agrotis segetum</i> : Synthesis and conformational analysis}},
  url          = {{https://lup.lub.lu.se/search/files/97402464/Marie_Bengtsson_Avhandling.pdf}},
  year         = {{1988}},
}