Structure-activity relationships for analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth, Agrotis segetum : Synthesis and conformational analysis
(1988)- Abstract
- Structure-activity relationships for 28 analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth Agrotis segetum, have been studied.Synthesis and conformational analysis of chain-elongated, chain-shortened, alkyne, alkenyne, diene and cyclic analogues, and configurational isomers are presented.A conformational-energy model for the interaction of a pheromone component with its receptor cell has been developed and tested.The model is shown to correlate measured electrophysiological single-cell activities with conformational energies calculated by the molecular mechanics (MM2/MMP2) method.A biologically active conformation of the natural pheromone component, (Z)-5-decenyl acetate, is suggested.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6015a2cc-4ffe-47eb-942e-b05af3eb1c89
- author
- Bengtsson, Marie
- supervisor
- publishing date
- 1988
- type
- Thesis
- publication status
- published
- subject
- keywords
- Structure-activity relationships, Conformational analysis, Molecular mechanics, Agrotis segetum, Sex pheromone, Receptor interaction, Analogues of (Z)-5-decenyl acetate
- pages
- 139 pages
- publisher
- Lund University
- ISBN
- 9907128066
- language
- English
- LU publication?
- no
- id
- 6015a2cc-4ffe-47eb-942e-b05af3eb1c89
- date added to LUP
- 2021-05-04 11:09:12
- date last changed
- 2021-05-05 18:56:36
@phdthesis{6015a2cc-4ffe-47eb-942e-b05af3eb1c89, abstract = {{Structure-activity relationships for 28 analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth <i>Agrotis segetum</i>, have been studied.Synthesis and conformational analysis of chain-elongated, chain-shortened, alkyne, alkenyne, diene and cyclic analogues, and configurational isomers are presented.A conformational-energy model for the interaction of a pheromone component with its receptor cell has been developed and tested.The model is shown to correlate measured electrophysiological single-cell activities with conformational energies calculated by the molecular mechanics (MM2/MMP2) method.A biologically active conformation of the natural pheromone component, (Z)-5-decenyl acetate, is suggested.<br/>}}, author = {{Bengtsson, Marie}}, isbn = {{9907128066}}, keywords = {{Structure-activity relationships; Conformational analysis; Molecular mechanics; Agrotis segetum; Sex pheromone; Receptor interaction; Analogues of (Z)-5-decenyl acetate}}, language = {{eng}}, publisher = {{Lund University}}, title = {{Structure-activity relationships for analogues of (Z)-5-decenyl acetate, a sex pheromone component of the turnip moth, <i>Agrotis segetum</i> : Synthesis and conformational analysis}}, url = {{https://lup.lub.lu.se/search/files/97402464/Marie_Bengtsson_Avhandling.pdf}}, year = {{1988}}, }