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Right ventricular remodeling after conduit replacement in patients with corrected tetralogy of Fallot - Evaluation by cardiac magnetic resonance

Guné, Henrik LU orcid ; Sjögren, Johan LU ; Carlsson, Marcus LU ; Gustafsson, Ronny LU ; Sjöberg, Pia LU and Nozohoor, Shahab LU (2019) In Journal of Cardiothoracic Surgery 14(1).
Abstract


Purpose: To evaluate the potential for right ventricular reverse remodelling after pulmonary valve replacement using cardiac magnetic resonance imaging, in adults with corrected tetralogy of Fallot and severe pulmonary insufficiency. Material and methods: Ten patients with previous correction of tetralogy of Fallot with severe pulmonary insufficiency accepted for pulmonary valve replacement were evaluated prospectively with cardiac magnetic resonance imaging preoperatively and re-evaluated 10 ± 5 months postoperatively. Follow up for survival was 100% complete with mean of 37 ± 12 months. Results: The preoperative mean indexed right ventricular end-diastolic volume was... (More)


Purpose: To evaluate the potential for right ventricular reverse remodelling after pulmonary valve replacement using cardiac magnetic resonance imaging, in adults with corrected tetralogy of Fallot and severe pulmonary insufficiency. Material and methods: Ten patients with previous correction of tetralogy of Fallot with severe pulmonary insufficiency accepted for pulmonary valve replacement were evaluated prospectively with cardiac magnetic resonance imaging preoperatively and re-evaluated 10 ± 5 months postoperatively. Follow up for survival was 100% complete with mean of 37 ± 12 months. Results: The preoperative mean indexed right ventricular end-diastolic volume was reduced from 161 ± 33 ml/m
2
to 120 ± 23 ml/m
2
postoperatively, p < 0.001. The preoperative mean indexed right ventricular stroke volume was reduced from 72 ± 20 ml/m
2
to 50 ± 6 ml/m
2
postoperatively, p = 0.002. After pulmonary valve replacement, the right ventricular ejection fraction did not change significantly (46% versus 42%, p = 0.337). Pulmonary insufficiency fraction decreased from 49% ± 11 to 1% ± 1 postoperatively, p < 0.001. Conclusions: Pulmonary valve replacement leads to a favourable early reverse remodelling with a reduction in RV volumes and improved function in all patients regardless of their preoperative indexed right ventricular volume.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult congenital heart disease, Outcome, Pulmonary valve replacement, Right ventricular function
in
Journal of Cardiothoracic Surgery
volume
14
issue
1
article number
77
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85064404969
  • pmid:30987651
ISSN
1749-8090
DOI
10.1186/s13019-019-0899-6
language
English
LU publication?
yes
id
60535f5a-845f-401f-8654-d48b02d3ce1c
date added to LUP
2019-05-03 11:01:11
date last changed
2024-05-25 03:06:54
@article{60535f5a-845f-401f-8654-d48b02d3ce1c,
  abstract     = {{<p><br>
                                                         Purpose: To evaluate the potential for right ventricular reverse remodelling after pulmonary valve replacement using cardiac magnetic resonance imaging, in adults with corrected tetralogy of Fallot and severe pulmonary insufficiency. Material and methods: Ten patients with previous correction of tetralogy of Fallot with severe pulmonary insufficiency accepted for pulmonary valve replacement were evaluated prospectively with cardiac magnetic resonance imaging preoperatively and re-evaluated 10 ± 5 months postoperatively. Follow up for survival was 100% complete with mean of 37 ± 12 months. Results: The preoperative mean indexed right ventricular end-diastolic volume was reduced from 161 ± 33 ml/m                             <br>
                            <sup>2</sup><br>
                                                          to 120 ± 23 ml/m                             <br>
                            <sup>2</sup><br>
                                                          postoperatively, p &lt; 0.001. The preoperative mean indexed right ventricular stroke volume was reduced from 72 ± 20 ml/m                             <br>
                            <sup>2</sup><br>
                                                          to 50 ± 6 ml/m                             <br>
                            <sup>2</sup><br>
                                                          postoperatively, p = 0.002. After pulmonary valve replacement, the right ventricular ejection fraction did not change significantly (46% versus 42%, p = 0.337). Pulmonary insufficiency fraction decreased from 49% ± 11 to 1% ± 1 postoperatively, p &lt; 0.001. Conclusions: Pulmonary valve replacement leads to a favourable early reverse remodelling with a reduction in RV volumes and improved function in all patients regardless of their preoperative indexed right ventricular volume.                         <br>
                        </p>}},
  author       = {{Guné, Henrik and Sjögren, Johan and Carlsson, Marcus and Gustafsson, Ronny and Sjöberg, Pia and Nozohoor, Shahab}},
  issn         = {{1749-8090}},
  keywords     = {{Adult congenital heart disease; Outcome; Pulmonary valve replacement; Right ventricular function}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Cardiothoracic Surgery}},
  title        = {{Right ventricular remodeling after conduit replacement in patients with corrected tetralogy of Fallot - Evaluation by cardiac magnetic resonance}},
  url          = {{http://dx.doi.org/10.1186/s13019-019-0899-6}},
  doi          = {{10.1186/s13019-019-0899-6}},
  volume       = {{14}},
  year         = {{2019}},
}