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Obesity contributes to the stealth peritoneal dissemination of ovarian cancer : a multi-institutional retrospective cohort study

Iyoshi, Shohei ; Sumi, Asami ; Yoshihara, Masato ; Kitami, Kazuhisa ; Mogi, Kazumasa ; Uno, Kaname LU orcid ; Fujimoto, Hiroki ; Miyamoto, Emiri ; Tano, Sho and Yoshikawa, Nobuhisa , et al. (2022) In Obesity 30(8). p.1599-1607
Abstract

Objective: The clinical significance of a higher BMI on the prognosis of ovarian cancer remains controversial; therefore, a more detailed analysis is demanded. This study investigated the impact of BMI on peritoneum-specific recurrence to clarify the involvement of adipose tissue in the proliferation of cancer cells at sites of peritoneal dissemination. Methods: Among 4,730 patients with malignant ovarian tumors, 280 diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IIIC epithelial ovarian cancer and who underwent complete resection in the primary surgery were included in the present study. Results: There were 42, 201, and 37 women in the low, normal, and high BMI groups, respectively.... (More)

Objective: The clinical significance of a higher BMI on the prognosis of ovarian cancer remains controversial; therefore, a more detailed analysis is demanded. This study investigated the impact of BMI on peritoneum-specific recurrence to clarify the involvement of adipose tissue in the proliferation of cancer cells at sites of peritoneal dissemination. Methods: Among 4,730 patients with malignant ovarian tumors, 280 diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IIIC epithelial ovarian cancer and who underwent complete resection in the primary surgery were included in the present study. Results: There were 42, 201, and 37 women in the low, normal, and high BMI groups, respectively. Peritoneum-specific recurrence-free survival and overall survival were both significantly shorter in patients with a high BMI than in those with a normal BMI (p = 0.028 and 0.018, respectively). No significant differences were observed in the distribution of sites of recurrence between these two groups. A multivariate analysis identified obesity as an independent prognostic factor in addition to pT3 tumor staging and positive ascites cytology. Conclusions: Patients with a high BMI had a significantly worse prognosis than those with a normal BMI, and peritoneal adipose tissue may have contributed to this difference.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
30
issue
8
pages
9 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:35851756
  • scopus:85134978637
ISSN
1930-7381
DOI
10.1002/oby.23497
language
English
LU publication?
yes
id
605903ad-0861-4fe7-9678-fa5ea260211c
date added to LUP
2022-11-02 14:29:24
date last changed
2024-06-27 16:42:55
@article{605903ad-0861-4fe7-9678-fa5ea260211c,
  abstract     = {{<p>Objective: The clinical significance of a higher BMI on the prognosis of ovarian cancer remains controversial; therefore, a more detailed analysis is demanded. This study investigated the impact of BMI on peritoneum-specific recurrence to clarify the involvement of adipose tissue in the proliferation of cancer cells at sites of peritoneal dissemination. Methods: Among 4,730 patients with malignant ovarian tumors, 280 diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IIIC epithelial ovarian cancer and who underwent complete resection in the primary surgery were included in the present study. Results: There were 42, 201, and 37 women in the low, normal, and high BMI groups, respectively. Peritoneum-specific recurrence-free survival and overall survival were both significantly shorter in patients with a high BMI than in those with a normal BMI (p = 0.028 and 0.018, respectively). No significant differences were observed in the distribution of sites of recurrence between these two groups. A multivariate analysis identified obesity as an independent prognostic factor in addition to pT3 tumor staging and positive ascites cytology. Conclusions: Patients with a high BMI had a significantly worse prognosis than those with a normal BMI, and peritoneal adipose tissue may have contributed to this difference.</p>}},
  author       = {{Iyoshi, Shohei and Sumi, Asami and Yoshihara, Masato and Kitami, Kazuhisa and Mogi, Kazumasa and Uno, Kaname and Fujimoto, Hiroki and Miyamoto, Emiri and Tano, Sho and Yoshikawa, Nobuhisa and Emoto, Ryo and Matsui, Shigeyuki and Kajiyama, Hiroaki}},
  issn         = {{1930-7381}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1599--1607}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Obesity}},
  title        = {{Obesity contributes to the stealth peritoneal dissemination of ovarian cancer : a multi-institutional retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1002/oby.23497}},
  doi          = {{10.1002/oby.23497}},
  volume       = {{30}},
  year         = {{2022}},
}