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Epigenetic modifications and gestational diabetes : A Systematic review of published literature

Moen, Gunn Helen; Sommer, Christine; Prasad, Rashmi B. LU ; Sletner, Line; Groop, Leif LU ; Qvigstad, Elisabeth and Birkeland, Kåre I. (2017) In European Journal of Endocrinology 176(5). p.247-267
Abstract

Objective: To summarize the current knowledge on epigenetic alterations in mother and offspring subjected to gestational diabetes (GDM) and indicate future topics for research. Design: Systematic review. Methods: We performed extensive searches in PubMed, EMBASE and Google scholar, using a combination of the search terms: GDM, gestational diabetes, epigenetic(s), methylation, histone modification, histone methylation, histone acetylation, microRNA and miRNA. Studies that compared women diagnosed with GDM and healthy controls were included. Two authors independently scanned the abstracts, and all included papers were read by at least two authors. The searches were completed on October 31st, 2016. Results: We identified 236 articles, of... (More)

Objective: To summarize the current knowledge on epigenetic alterations in mother and offspring subjected to gestational diabetes (GDM) and indicate future topics for research. Design: Systematic review. Methods: We performed extensive searches in PubMed, EMBASE and Google scholar, using a combination of the search terms: GDM, gestational diabetes, epigenetic(s), methylation, histone modification, histone methylation, histone acetylation, microRNA and miRNA. Studies that compared women diagnosed with GDM and healthy controls were included. Two authors independently scanned the abstracts, and all included papers were read by at least two authors. The searches were completed on October 31st, 2016. Results: We identified 236 articles, of which 43 were considered relevant for this systematic review. Studies published showed that epigenetic alterations could be found in both mothers with GDM and their offspring. However, differences in methodology, diagnostic criteria for GDM and populations studied, together with a limited number of published studies and small sample sizes, preclude clear conclusions about the role of epigenetic modifications in transmitting risk from GDM mothers to their offspring. Conclusion: The current research literature suggests that GDM may have impact on epigenetic modifications in the mother and offspring. However, larger studies that include multiple cohorts of GDM patients and their offspring are needed.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Endocrinology
volume
176
issue
5
pages
247 - 267
publisher
Society of the European Journal of Endocrinology
external identifiers
  • scopus:85017500307
ISSN
0804-4643
DOI
10.1530/EJE-16-1017
language
English
LU publication?
yes
id
605af63e-4e48-4f09-a955-4ce48dc5dec4
date added to LUP
2017-05-04 16:27:28
date last changed
2017-05-04 16:27:28
@article{605af63e-4e48-4f09-a955-4ce48dc5dec4,
  abstract     = {<p>Objective: To summarize the current knowledge on epigenetic alterations in mother and offspring subjected to gestational diabetes (GDM) and indicate future topics for research. Design: Systematic review. Methods: We performed extensive searches in PubMed, EMBASE and Google scholar, using a combination of the search terms: GDM, gestational diabetes, epigenetic(s), methylation, histone modification, histone methylation, histone acetylation, microRNA and miRNA. Studies that compared women diagnosed with GDM and healthy controls were included. Two authors independently scanned the abstracts, and all included papers were read by at least two authors. The searches were completed on October 31st, 2016. Results: We identified 236 articles, of which 43 were considered relevant for this systematic review. Studies published showed that epigenetic alterations could be found in both mothers with GDM and their offspring. However, differences in methodology, diagnostic criteria for GDM and populations studied, together with a limited number of published studies and small sample sizes, preclude clear conclusions about the role of epigenetic modifications in transmitting risk from GDM mothers to their offspring. Conclusion: The current research literature suggests that GDM may have impact on epigenetic modifications in the mother and offspring. However, larger studies that include multiple cohorts of GDM patients and their offspring are needed.</p>},
  author       = {Moen, Gunn Helen and Sommer, Christine and Prasad, Rashmi B. and Sletner, Line and Groop, Leif and Qvigstad, Elisabeth and Birkeland, Kåre I.},
  issn         = {0804-4643},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {247--267},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology},
  title        = {Epigenetic modifications and gestational diabetes : A Systematic review of published literature},
  url          = {http://dx.doi.org/10.1530/EJE-16-1017},
  volume       = {176},
  year         = {2017},
}