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Neural and head induction by Insulin-like growth factor signals

Pera, Edgar LU ; Wessely, Oliver; Li, Su-Yu and De Robertis, Edward (2001) In Developmental Cell 1(5). p.656-665
Abstract
Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for... (More)
Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
in
Developmental Cell
volume
1
issue
5
pages
656 - 665
publisher
Cell Press
external identifiers
  • scopus:0035512635
ISSN
1534-5807
DOI
10.1016/S1534-5807(01)00069-7
language
English
LU publication?
no
id
606673b1-4a26-4f62-ae8f-c841cacfec1b
date added to LUP
2018-02-20 14:31:54
date last changed
2018-04-01 04:38:36
@article{606673b1-4a26-4f62-ae8f-c841cacfec1b,
  abstract     = {Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus.},
  author       = {Pera, Edgar and Wessely, Oliver and Li, Su-Yu and De Robertis, Edward},
  issn         = {1534-5807},
  language     = {eng},
  number       = {5},
  pages        = {656--665},
  publisher    = {Cell Press},
  series       = {Developmental Cell},
  title        = {Neural and head induction by Insulin-like growth factor signals},
  url          = {http://dx.doi.org/10.1016/S1534-5807(01)00069-7},
  volume       = {1},
  year         = {2001},
}