Neural and head induction by Insulin-like growth factor signals
(2001) In Developmental Cell 1(5). p.656-665- Abstract
- Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for... (More)
- Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/606673b1-4a26-4f62-ae8f-c841cacfec1b
- author
- Pera, Edgar LU ; Wessely, Oliver ; Li, Su-Yu and De Robertis, Edward
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- in
- Developmental Cell
- volume
- 1
- issue
- 5
- pages
- 656 - 665
- publisher
- Cell Press
- external identifiers
-
- scopus:0035512635
- ISSN
- 1534-5807
- DOI
- 10.1016/S1534-5807(01)00069-7
- language
- English
- LU publication?
- no
- id
- 606673b1-4a26-4f62-ae8f-c841cacfec1b
- date added to LUP
- 2018-02-20 14:31:54
- date last changed
- 2022-04-09 22:03:25
@article{606673b1-4a26-4f62-ae8f-c841cacfec1b, abstract = {{Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus.}}, author = {{Pera, Edgar and Wessely, Oliver and Li, Su-Yu and De Robertis, Edward}}, issn = {{1534-5807}}, language = {{eng}}, number = {{5}}, pages = {{656--665}}, publisher = {{Cell Press}}, series = {{Developmental Cell}}, title = {{Neural and head induction by Insulin-like growth factor signals}}, url = {{http://dx.doi.org/10.1016/S1534-5807(01)00069-7}}, doi = {{10.1016/S1534-5807(01)00069-7}}, volume = {{1}}, year = {{2001}}, }