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Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperresponsiveness.

Tufvesson, Ellen LU ; Aronsson, David LU ; Ankerst, Jaro LU ; George, Steven C and Bjermer, Leif LU (2007) In Respiratory Medicine 101(11). p.2321-2326
Abstract
Allergic rhinitis is a predisposing factor for developing clinical asthma. Moreover, allergic rhinitis is often associated with bronchial hyperresponsiveness (BHR). We hypothesise that patients with asthma have more small airway involvement than those with allergic rhinitis and BHR alone. The aim of this study was to assess peripheral and proximal NO concentration in rhinitic subjects, and to correlate the peripheral NO concentration to the peripheral obstruction in response to methacholine. Patients with allergic rhinitis with or without BHR, or clinical asthma were investigated in and out of the allergy season. Healthy subjects served as controls. Fractional exhaled NO was performed, and peripheral NO concentration and proximal flux of... (More)
Allergic rhinitis is a predisposing factor for developing clinical asthma. Moreover, allergic rhinitis is often associated with bronchial hyperresponsiveness (BHR). We hypothesise that patients with asthma have more small airway involvement than those with allergic rhinitis and BHR alone. The aim of this study was to assess peripheral and proximal NO concentration in rhinitic subjects, and to correlate the peripheral NO concentration to the peripheral obstruction in response to methacholine. Patients with allergic rhinitis with or without BHR, or clinical asthma were investigated in and out of the allergy season. Healthy subjects served as controls. Fractional exhaled NO was performed, and peripheral NO concentration and proximal flux of NO was calculated. Methacholine test was performed including impulse oscillometry. Rhinitic patients with asthma demonstrate an increase in both proximal and peripheral NO compared to those with rhinitis atone or those with BHR. There is a trend of increased peripheral NO from patients with rhinitis only, rhinitis and BHR, to rhinitis with asthma. The increase in peripheral NO correlated with an increased peripheral obstruction in response to methacholine. Patients with seasonal allergic rhinitis demonstrated a decrease in both proximal and peripheral NO in the off-season. The results support our hypothesis that rhinitic patients with asthma have more peripheral lung inflammation and small airway involvement compared to rhinitic patients with BHR alone. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asthma, hyperresponsiveness, nitric oxide, rhinitis, proximal, peripheral, bronchail
in
Respiratory Medicine
volume
101
issue
11
pages
2321 - 2326
publisher
Elsevier
external identifiers
  • wos:000250344100013
  • scopus:34748839579
ISSN
1532-3064
DOI
10.1016/j.rmed.2007.06.015
language
English
LU publication?
yes
id
f750100d-7bb0-4176-93f1-1f9adc11a691 (old id 606989)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17686621&dopt=Abstract
date added to LUP
2007-12-20 10:30:09
date last changed
2017-04-02 04:09:44
@article{f750100d-7bb0-4176-93f1-1f9adc11a691,
  abstract     = {Allergic rhinitis is a predisposing factor for developing clinical asthma. Moreover, allergic rhinitis is often associated with bronchial hyperresponsiveness (BHR). We hypothesise that patients with asthma have more small airway involvement than those with allergic rhinitis and BHR alone. The aim of this study was to assess peripheral and proximal NO concentration in rhinitic subjects, and to correlate the peripheral NO concentration to the peripheral obstruction in response to methacholine. Patients with allergic rhinitis with or without BHR, or clinical asthma were investigated in and out of the allergy season. Healthy subjects served as controls. Fractional exhaled NO was performed, and peripheral NO concentration and proximal flux of NO was calculated. Methacholine test was performed including impulse oscillometry. Rhinitic patients with asthma demonstrate an increase in both proximal and peripheral NO compared to those with rhinitis atone or those with BHR. There is a trend of increased peripheral NO from patients with rhinitis only, rhinitis and BHR, to rhinitis with asthma. The increase in peripheral NO correlated with an increased peripheral obstruction in response to methacholine. Patients with seasonal allergic rhinitis demonstrated a decrease in both proximal and peripheral NO in the off-season. The results support our hypothesis that rhinitic patients with asthma have more peripheral lung inflammation and small airway involvement compared to rhinitic patients with BHR alone.},
  author       = {Tufvesson, Ellen and Aronsson, David and Ankerst, Jaro and George, Steven C and Bjermer, Leif},
  issn         = {1532-3064},
  keyword      = {asthma,hyperresponsiveness,nitric oxide,rhinitis,proximal,peripheral,bronchail},
  language     = {eng},
  number       = {11},
  pages        = {2321--2326},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperresponsiveness.},
  url          = {http://dx.doi.org/10.1016/j.rmed.2007.06.015},
  volume       = {101},
  year         = {2007},
}