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New technologies to replace current blood typing reagents.

Storry, Jill LU (2007) In Current Opinion in Hematology 14(6). p.677-681
Abstract
Purpose of review This review summarizes recent developments in blood grouping and compatibility testing in transfusion medicine. Recent findings Identification of the molecular characteristics of the major human blood groups has provided an opportunity to develop methods for blood group phenotyping using DNA-based technology. Various studies have demonstrated the feasibility of such an approach and have demonstrated the potential to change current procedures for identifying compatible blood, both in routine settings and in highly immunized patients, for whom compatible blood is difficult to obtain. In the obstetric setting, isolation of cell-free DNA from maternal plasma for fetal blood grouping provides a minimally invasive method for... (More)
Purpose of review This review summarizes recent developments in blood grouping and compatibility testing in transfusion medicine. Recent findings Identification of the molecular characteristics of the major human blood groups has provided an opportunity to develop methods for blood group phenotyping using DNA-based technology. Various studies have demonstrated the feasibility of such an approach and have demonstrated the potential to change current procedures for identifying compatible blood, both in routine settings and in highly immunized patients, for whom compatible blood is difficult to obtain. In the obstetric setting, isolation of cell-free DNA from maternal plasma for fetal blood grouping provides a minimally invasive method for determining the risk for haemolytic disease in the newborn. Recombinant technology for synthesizing blood group proteins, although in its infancy, has the potential to change longstanding antibody identification procedures. Summary The molecular revolution occurring throughout medicine is broadly manifest in all areas of transfusion medicine and should contribute to transfusion safety. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
microarray, DNA analysis, blood groups
in
Current Opinion in Hematology
volume
14
issue
6
pages
677 - 681
external identifiers
  • wos:000250165000012
  • scopus:34848911111
ISSN
1531-7048
language
English
LU publication?
yes
id
1d04378f-4600-4caf-9111-63af8a75b65c (old id 607505)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17898574&dopt=Abstract
date added to LUP
2008-01-03 08:49:17
date last changed
2017-04-09 04:25:13
@article{1d04378f-4600-4caf-9111-63af8a75b65c,
  abstract     = {Purpose of review This review summarizes recent developments in blood grouping and compatibility testing in transfusion medicine. Recent findings Identification of the molecular characteristics of the major human blood groups has provided an opportunity to develop methods for blood group phenotyping using DNA-based technology. Various studies have demonstrated the feasibility of such an approach and have demonstrated the potential to change current procedures for identifying compatible blood, both in routine settings and in highly immunized patients, for whom compatible blood is difficult to obtain. In the obstetric setting, isolation of cell-free DNA from maternal plasma for fetal blood grouping provides a minimally invasive method for determining the risk for haemolytic disease in the newborn. Recombinant technology for synthesizing blood group proteins, although in its infancy, has the potential to change longstanding antibody identification procedures. Summary The molecular revolution occurring throughout medicine is broadly manifest in all areas of transfusion medicine and should contribute to transfusion safety.},
  author       = {Storry, Jill},
  issn         = {1531-7048},
  keyword      = {microarray,DNA analysis,blood groups},
  language     = {eng},
  number       = {6},
  pages        = {677--681},
  series       = {Current Opinion in Hematology},
  title        = {New technologies to replace current blood typing reagents.},
  volume       = {14},
  year         = {2007},
}