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Ventricular–arterial coupling (VAC) in a population-based cohort of middle-aged individuals: The STANISLAS cohort

Holm, H. LU ; Magnusson, M. LU orcid ; Jujic, A. LU ; Pugliese, Nicola Ricardo ; Bozec, E. ; Lamiral, Z. ; Huttin, O. ; Zannad, F. ; Rossignol, P. and Girerd, N. (2023) In Atherosclerosis 374. p.11-20
Abstract
Background and aims
Data exploring normal values of different ventricular–arterial coupling (VAC) parameters and their association with anthropometric and cardiovascular (CV) factors are scarce. We aim to report values of two different methods of VAC assessment according to age and sex and explore their association with CV factors within a large population-based cohort of middle-aged individuals.

Methods
For 1333 (mean age 48 ± 14) individuals participating in the 4th visit of the STANISLAS cohort, VAC was assessed by two methods [1]: arterial elastance (Ea)/end-systolic elastance (Ees) and [2] Pulse wave velocity (PWV)/Global longitudinal strain (GLS).

Results
The mean values of Ea/Ees and PWV/GLS were 1.06 ±... (More)
Background and aims
Data exploring normal values of different ventricular–arterial coupling (VAC) parameters and their association with anthropometric and cardiovascular (CV) factors are scarce. We aim to report values of two different methods of VAC assessment according to age and sex and explore their association with CV factors within a large population-based cohort of middle-aged individuals.

Methods
For 1333 (mean age 48 ± 14) individuals participating in the 4th visit of the STANISLAS cohort, VAC was assessed by two methods [1]: arterial elastance (Ea)/end-systolic elastance (Ees) and [2] Pulse wave velocity (PWV)/Global longitudinal strain (GLS).

Results
The mean values of Ea/Ees and PWV/GLS were 1.06 ± 0.20 and 0.42 ± 0.12, respectively. The two methods of VAC assessment were poorly correlated (Pearson's correlation coefficient r = 0.14 (0.08; 0.19)). Increased PWV/GLS was associated with older age and a higher degree of cardiovascular risk factors (i.e., BMI, blood pressure, LDL, diabetes, hypertension) in the whole population as well as in the parent generation. In contrast, higher Ea/Ees were associated with decreasing age, and lower prevalence of risk factors in the whole cohort but neutrally associated with risk factors in the parent generation.

Conclusions
Higher PWV/GLS is significantly associated with CV factors regardless of age. In contrast, worse Ea/Ees is associated with a better CV risk profile when considering individuals aged 30 to 70 but neutrally associated with CV factors when considering only older patients. These results may suggest that PWV/GLS should preferably be used to explore VAC. In addition, age-individualized threshold of Ea/Ees should be used. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Atherosclerosis
volume
374
pages
11 - 20
publisher
Elsevier
external identifiers
  • scopus:85156132356
  • pmid:37159989
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2023.04.010
language
English
LU publication?
yes
id
607545cc-50aa-437a-801d-7da1dc815d29
date added to LUP
2023-05-03 10:00:06
date last changed
2023-12-07 02:43:49
@article{607545cc-50aa-437a-801d-7da1dc815d29,
  abstract     = {{Background and aims<br/>Data exploring normal values of different ventricular–arterial coupling (VAC) parameters and their association with anthropometric and cardiovascular (CV) factors are scarce. We aim to report values of two different methods of VAC assessment according to age and sex and explore their association with CV factors within a large population-based cohort of middle-aged individuals.<br/><br/>Methods<br/>For 1333 (mean age 48 ± 14) individuals participating in the 4th visit of the STANISLAS cohort, VAC was assessed by two methods [1]: arterial elastance (Ea)/end-systolic elastance (Ees) and [2] Pulse wave velocity (PWV)/Global longitudinal strain (GLS).<br/><br/>Results<br/>The mean values of Ea/Ees and PWV/GLS were 1.06 ± 0.20 and 0.42 ± 0.12, respectively. The two methods of VAC assessment were poorly correlated (Pearson's correlation coefficient r = 0.14 (0.08; 0.19)). Increased PWV/GLS was associated with older age and a higher degree of cardiovascular risk factors (i.e., BMI, blood pressure, LDL, diabetes, hypertension) in the whole population as well as in the parent generation. In contrast, higher Ea/Ees were associated with decreasing age, and lower prevalence of risk factors in the whole cohort but neutrally associated with risk factors in the parent generation.<br/><br/>Conclusions<br/>Higher PWV/GLS is significantly associated with CV factors regardless of age. In contrast, worse Ea/Ees is associated with a better CV risk profile when considering individuals aged 30 to 70 but neutrally associated with CV factors when considering only older patients. These results may suggest that PWV/GLS should preferably be used to explore VAC. In addition, age-individualized threshold of Ea/Ees should be used.}},
  author       = {{Holm, H. and Magnusson, M. and Jujic, A. and Pugliese, Nicola Ricardo and Bozec, E. and Lamiral, Z. and Huttin, O. and Zannad, F. and Rossignol, P. and Girerd, N.}},
  issn         = {{1879-1484}},
  language     = {{eng}},
  pages        = {{11--20}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Ventricular–arterial coupling (VAC) in a population-based cohort of middle-aged individuals: The STANISLAS cohort}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2023.04.010}},
  doi          = {{10.1016/j.atherosclerosis.2023.04.010}},
  volume       = {{374}},
  year         = {{2023}},
}