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Acute decrease of coronary flow after indomethacin delivery in newborn lambs.

Harling, Solweig LU ; Oskarsson, Gylfi; Gudmundsson, Saemundur LU and Pesonen, Erkki LU (2007) In Acta Pædiatrica 96(10). p.1460-1463
Abstract
Aim: To document the effects of indomethacin (IND) on coronary flow. Methods: We studied nine premature lambs during the first day of life. The gestational age varied between 132 and 134 days (term 145 days) and weight 3.1-4.7 kg. Coronary flow velocities were recorded with an intracoronary Doppler guide wire in the proximal left anterior descending coronary artery (LAD). Average peak flow velocity was measured before, during and after an intravenous IND injection of 0.2 mg per kilogram of body weight. Results: IND increased systemic blood pressure (p < 0.05) and rate pressure product (RPP; p < 0.05) indicating that IND increased cardiac workload. IND decreased coronary average peak flow velocity in all lambs (p < 0.05). The... (More)
Aim: To document the effects of indomethacin (IND) on coronary flow. Methods: We studied nine premature lambs during the first day of life. The gestational age varied between 132 and 134 days (term 145 days) and weight 3.1-4.7 kg. Coronary flow velocities were recorded with an intracoronary Doppler guide wire in the proximal left anterior descending coronary artery (LAD). Average peak flow velocity was measured before, during and after an intravenous IND injection of 0.2 mg per kilogram of body weight. Results: IND increased systemic blood pressure (p < 0.05) and rate pressure product (RPP; p < 0.05) indicating that IND increased cardiac workload. IND decreased coronary average peak flow velocity in all lambs (p < 0.05). The maximal fall in coronary velocity appeared after 3 min (range 1-7 min) and was regained 10 min (range 4-53 min) after the drug delivery. The maximal reduction of coronary average peak flow velocity was 52% (median 26). The recovery time was directly related to the maximal reduction of the coronary average peak flow velocity (R = 0.91, R-2 0.84, p < 0.002). Conclusion: Coronary flow velocity decreased markedly in premature born lambs given a bolus dose of IND. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intracoronary Doppler guide wire, infant, coronary flow, indomethacin
in
Acta Pædiatrica
volume
96
issue
10
pages
1460 - 1463
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000249481500019
  • scopus:34548663876
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2007.00455.x
language
English
LU publication?
yes
id
d9df8186-0716-4c21-bc27-08843486710f (old id 607872)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17850400&dopt=Abstract
date added to LUP
2007-12-11 08:41:43
date last changed
2017-01-01 07:23:55
@article{d9df8186-0716-4c21-bc27-08843486710f,
  abstract     = {Aim: To document the effects of indomethacin (IND) on coronary flow. Methods: We studied nine premature lambs during the first day of life. The gestational age varied between 132 and 134 days (term 145 days) and weight 3.1-4.7 kg. Coronary flow velocities were recorded with an intracoronary Doppler guide wire in the proximal left anterior descending coronary artery (LAD). Average peak flow velocity was measured before, during and after an intravenous IND injection of 0.2 mg per kilogram of body weight. Results: IND increased systemic blood pressure (p &lt; 0.05) and rate pressure product (RPP; p &lt; 0.05) indicating that IND increased cardiac workload. IND decreased coronary average peak flow velocity in all lambs (p &lt; 0.05). The maximal fall in coronary velocity appeared after 3 min (range 1-7 min) and was regained 10 min (range 4-53 min) after the drug delivery. The maximal reduction of coronary average peak flow velocity was 52% (median 26). The recovery time was directly related to the maximal reduction of the coronary average peak flow velocity (R = 0.91, R-2 0.84, p &lt; 0.002). Conclusion: Coronary flow velocity decreased markedly in premature born lambs given a bolus dose of IND.},
  author       = {Harling, Solweig and Oskarsson, Gylfi and Gudmundsson, Saemundur and Pesonen, Erkki},
  issn         = {1651-2227},
  keyword      = {intracoronary Doppler guide wire,infant,coronary flow,indomethacin},
  language     = {eng},
  number       = {10},
  pages        = {1460--1463},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Acute decrease of coronary flow after indomethacin delivery in newborn lambs.},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2007.00455.x},
  volume       = {96},
  year         = {2007},
}