Mechanical Reperfusion Following Prolonged Global Cerebral Ischemia Attenuates Brain Injury
Lindblom, Rickard P.F. ; Tovedal, Thomas ; Norlin, Bo ; Hillered, Lars ; Englund, Elisabet LU
and Thelin, Stefan
(2021)
In Journal of Cardiovascular Translational Research
14(2).
p.338-347
- Abstract
Previous experiments demonstrated improved outcome following prolonged cerebral ischemia given controlled brain reperfusion using extracorporeal circulation. The current study further investigates this. Young adult pigs were exposed to 30 min of global normothermic cerebral ischemia, achieved through intrathoracic clamping of cerebral arteries, followed by 20 min of isolated mechanical brain reperfusion. Leukocyte-filtered blood was delivered by a roller-pump at fixed pressure and flow. One experimental group additionally had a custom-made buffer solution delivered at 1:8 ratio with the blood. Hemodynamics including intracranial pressure were monitored. Blood gases were from peripheral arteries and the sagittal sinus, and... (More)
Previous experiments demonstrated improved outcome following prolonged cerebral ischemia given controlled brain reperfusion using extracorporeal circulation. The current study further investigates this. Young adult pigs were exposed to 30 min of global normothermic cerebral ischemia, achieved through intrathoracic clamping of cerebral arteries, followed by 20 min of isolated mechanical brain reperfusion. Leukocyte-filtered blood was delivered by a roller-pump at fixed pressure and flow. One experimental group additionally had a custom-made buffer solution delivered at 1:8 ratio with the blood. Hemodynamics including intracranial pressure were monitored. Blood gases were from peripheral arteries and the sagittal sinus, and intraparenchymal brain microdialysis was performed. The brains were examined by a neuropathologist. The group with the added buffer showed lower intracranial pressure as well as decreased intraparenchymal glycerol and less signs of excitotoxicity and ischemia, although histology revealed similar degrees of injury. A customized mechanical reperfusion improves multiple parameters after prolonged normothermic global cerebral ischemia. [Figure not available: see fulltext.]
(Less)
- author
- Lindblom, Rickard P.F.
; Tovedal, Thomas
; Norlin, Bo
; Hillered, Lars
; Englund, Elisabet
LU
and Thelin, Stefan
- organization
- publishing date
- 2021-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Global cerebral ischemia, Mechanical circulation, Reperfusion
- in
- Journal of Cardiovascular Translational Research
- volume
- 14
- issue
- 2
- pages
- 10 pages
- publisher
- Springer
- external identifiers
-
- scopus:85088159450
- pmid:32681452
- ISSN
- 1937-5387
- DOI
- 10.1007/s12265-020-10058-9
- language
- English
- LU publication?
- yes
- id
- 6079f74d-7ce3-4d9b-bc13-c0c7d7a6fdb9
- date added to LUP
- 2020-07-30 12:39:51
- date last changed
- 2024-11-14 11:08:43
@article{6079f74d-7ce3-4d9b-bc13-c0c7d7a6fdb9,
abstract = {{<p>Previous experiments demonstrated improved outcome following prolonged cerebral ischemia given controlled brain reperfusion using extracorporeal circulation. The current study further investigates this. Young adult pigs were exposed to 30 min of global normothermic cerebral ischemia, achieved through intrathoracic clamping of cerebral arteries, followed by 20 min of isolated mechanical brain reperfusion. Leukocyte-filtered blood was delivered by a roller-pump at fixed pressure and flow. One experimental group additionally had a custom-made buffer solution delivered at 1:8 ratio with the blood. Hemodynamics including intracranial pressure were monitored. Blood gases were from peripheral arteries and the sagittal sinus, and intraparenchymal brain microdialysis was performed. The brains were examined by a neuropathologist. The group with the added buffer showed lower intracranial pressure as well as decreased intraparenchymal glycerol and less signs of excitotoxicity and ischemia, although histology revealed similar degrees of injury. A customized mechanical reperfusion improves multiple parameters after prolonged normothermic global cerebral ischemia. [Figure not available: see fulltext.]</p>}},
author = {{Lindblom, Rickard P.F. and Tovedal, Thomas and Norlin, Bo and Hillered, Lars and Englund, Elisabet and Thelin, Stefan}},
issn = {{1937-5387}},
keywords = {{Global cerebral ischemia; Mechanical circulation; Reperfusion}},
language = {{eng}},
month = {{04}},
number = {{2}},
pages = {{338--347}},
publisher = {{Springer}},
series = {{Journal of Cardiovascular Translational Research}},
title = {{Mechanical Reperfusion Following Prolonged Global Cerebral Ischemia Attenuates Brain Injury}},
url = {{http://dx.doi.org/10.1007/s12265-020-10058-9}},
doi = {{10.1007/s12265-020-10058-9}},
volume = {{14}},
year = {{2021}},
}